KLF17_HUMAN
ID KLF17_HUMAN Reviewed; 389 AA.
AC Q5JT82; Q86VQ7; Q8N805;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Krueppel-like factor 17;
DE AltName: Full=Zinc finger protein 393;
GN Name=KLF17; Synonyms=ZNF393;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ASN-35 AND THR-57.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS THR-57 AND SER-156.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, AND DNA-BINDING.
RX PubMed=16460907; DOI=10.1016/j.ygeno.2005.12.011;
RA van Vliet J., Crofts L.A., Quinlan K.G.R., Czolij R., Perkins A.C.,
RA Crossley M.;
RT "Human KLF17 is a new member of the Sp/KLF family of transcription
RT factors.";
RL Genomics 87:474-482(2006).
CC -!- FUNCTION: Transcription repressor that binds to the promoter of target
CC genes and prevents their expression. Acts as a negative regulator of
CC epithelial-mesenchymal transition and metastasis in breast cancer.
CC Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a
CC key metastasis regulator in breast cancer, and repress its expression.
CC May be a germ cell-specific transcription factor that plays important
CC roles in spermatid differentiation and oocyte development (By
CC similarity). {ECO:0000250, ECO:0000269|PubMed:16460907}.
CC -!- INTERACTION:
CC Q5JT82; Q96Q77: CIB3; NbExp=6; IntAct=EBI-10292791, EBI-10292696;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Sp1 C2H2-type zinc-finger protein family.
CC {ECO:0000305}.
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DR EMBL; AK097479; BAC05070.1; -; mRNA.
DR EMBL; AL356653; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC049844; AAH49844.1; -; mRNA.
DR CCDS; CCDS508.1; -.
DR RefSeq; NP_775755.3; NM_173484.3.
DR AlphaFoldDB; Q5JT82; -.
DR SMR; Q5JT82; -.
DR BioGRID; 126099; 2.
DR IntAct; Q5JT82; 2.
DR STRING; 9606.ENSP00000361373; -.
DR iPTMnet; Q5JT82; -.
DR PhosphoSitePlus; Q5JT82; -.
DR BioMuta; KLF17; -.
DR DMDM; 74762198; -.
DR MassIVE; Q5JT82; -.
DR PaxDb; Q5JT82; -.
DR PeptideAtlas; Q5JT82; -.
DR PRIDE; Q5JT82; -.
DR Antibodypedia; 18431; 203 antibodies from 30 providers.
DR DNASU; 128209; -.
DR Ensembl; ENST00000372299.4; ENSP00000361373.3; ENSG00000171872.5.
DR GeneID; 128209; -.
DR KEGG; hsa:128209; -.
DR MANE-Select; ENST00000372299.4; ENSP00000361373.3; NM_173484.4; NP_775755.3.
DR UCSC; uc001clp.4; human.
DR CTD; 128209; -.
DR DisGeNET; 128209; -.
DR GeneCards; KLF17; -.
DR HGNC; HGNC:18830; KLF17.
DR HPA; ENSG00000171872; Tissue enriched (testis).
DR MIM; 609602; gene.
DR neXtProt; NX_Q5JT82; -.
DR OpenTargets; ENSG00000171872; -.
DR PharmGKB; PA134877071; -.
DR VEuPathDB; HostDB:ENSG00000171872; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162020; -.
DR HOGENOM; CLU_827795_0_0_1; -.
DR InParanoid; Q5JT82; -.
DR OMA; MMPLGEP; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q5JT82; -.
DR TreeFam; TF315506; -.
DR PathwayCommons; Q5JT82; -.
DR SignaLink; Q5JT82; -.
DR BioGRID-ORCS; 128209; 23 hits in 1087 CRISPR screens.
DR ChiTaRS; KLF17; human.
DR GeneWiki; KLF17; -.
DR GenomeRNAi; 128209; -.
DR Pharos; Q5JT82; Tbio.
DR PRO; PR:Q5JT82; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5JT82; protein.
DR Bgee; ENSG00000171872; Expressed in left testis and 61 other tissues.
DR ExpressionAtlas; Q5JT82; baseline and differential.
DR Genevisible; Q5JT82; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..389
FT /note="Krueppel-like factor 17"
FT /id="PRO_0000047555"
FT ZN_FING 283..307
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 313..337
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 343..365
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 239..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 356..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 35
FT /note="I -> N (in dbSNP:rs11210969)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_052719"
FT VARIANT 57
FT /note="S -> T (in dbSNP:rs2429051)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_052720"
FT VARIANT 80
FT /note="Q -> H (in dbSNP:rs6656945)"
FT /id="VAR_052721"
FT VARIANT 156
FT /note="N -> S (in dbSNP:rs2485652)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_026198"
SQ SEQUENCE 389 AA; 42577 MW; 0AA451DB23C2580A CRC64;
MYGRPQAEME QEAGELSRWQ AAHQAAQDNE NSAPILNMSS SSGSSGVHTS WNQGLPSIQH
FPHSAEMLGS PLVSVEAPGQ NVNEGGPQFS MPLPERGMSY CPQATLTPSR MIYCQRMSPP
QQEMTIFSGP QLMPVGEPNI PRVARPFGGN LRMPPNGLPV SASTGIPIMS HTGNPPVPYP
GLSTVPSDET LLGPTVPSTE AQAVLPSMAQ MLPPQDAHDL GMPPAESQSL LVLGSQDSLV
SQPDSQEGPF LPEQPGPAPQ TVEKNSRPQE GTGRRGSSEA RPYCCNYENC GKAYTKRSHL
VSHQRKHTGE RPYSCNWESC SWSFFRSDEL RRHMRVHTRY RPYKCDQCSR EFMRSDHLKQ
HQKTHRPGPS DPQANNNNGE QDSPPAAGP
