KLF17_MOUSE
ID KLF17_MOUSE Reviewed; 341 AA.
AC Q8CFA7; B1ASI5; Q3UT30; Q6P233; Q9D351;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Krueppel-like factor 17;
DE AltName: Full=Germ cell-specific zinc finger protein;
DE AltName: Full=Zinc finger protein 393;
GN Name=Klf17; Synonyms=Gzf, Zfp393, Znf393;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=129/Sv X C57BL; TISSUE=Testis;
RX PubMed=12351194; DOI=10.1016/s0925-4773(02)00258-7;
RA Yan W., Burns K.H., Ma L., Matzuk M.M.;
RT "Identification of Zfp393, a germ cell-specific gene encoding a novel zinc
RT finger protein.";
RL Mech. Dev. 118:233-239(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Egg;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Egg;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP FUNCTION, AND DNA-BINDING.
RX PubMed=19801974; DOI=10.1038/ncb1974;
RA Gumireddy K., Li A., Gimotty P.A., Klein-Szanto A.J., Showe L.C.,
RA Katsaros D., Coukos G., Zhang L., Huang Q.;
RT "KLF17 is a negative regulator of epithelial-mesenchymal transition and
RT metastasis in breast cancer.";
RL Nat. Cell Biol. 11:1297-1304(2009).
CC -!- FUNCTION: Transcription repressor that binds to the promoter of target
CC genes and prevents their expression. Acts as a negative regulator of
CC epithelial-mesenchymal transition and metastasis in breast cancer.
CC Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a
CC key metastasis regulator in breast cancer, and repress its expression.
CC May be a germ cell-specific transcription factor that plays important
CC roles in spermatid differentiation and oocyte development.
CC {ECO:0000269|PubMed:19801974}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Exclusively expressed in testis and ovary.
CC Localized to step 3-8 spermatids in testis and growing oocytes in
CC ovary. {ECO:0000269|PubMed:12351194}.
CC -!- SIMILARITY: Belongs to the Sp1 C2H2-type zinc-finger protein family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF508984; AAN31656.1; -; mRNA.
DR EMBL; AK018361; BAB31177.1; -; mRNA.
DR EMBL; AK139827; BAE24150.1; -; mRNA.
DR EMBL; AL627128; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL671520; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466552; EDL30543.1; -; Genomic_DNA.
DR EMBL; BC064748; AAH64748.1; -; mRNA.
DR CCDS; CCDS18537.1; -.
DR RefSeq; NP_083692.2; NM_029416.2.
DR AlphaFoldDB; Q8CFA7; -.
DR SMR; Q8CFA7; -.
DR STRING; 10090.ENSMUSP00000052316; -.
DR PhosphoSitePlus; Q8CFA7; -.
DR PaxDb; Q8CFA7; -.
DR PRIDE; Q8CFA7; -.
DR Antibodypedia; 18431; 203 antibodies from 30 providers.
DR DNASU; 75753; -.
DR Ensembl; ENSMUST00000062747; ENSMUSP00000052316; ENSMUSG00000048626.
DR GeneID; 75753; -.
DR KEGG; mmu:75753; -.
DR UCSC; uc008uix.1; mouse.
DR CTD; 128209; -.
DR MGI; MGI:2181068; Klf17.
DR VEuPathDB; HostDB:ENSMUSG00000048626; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162020; -.
DR HOGENOM; CLU_827795_0_0_1; -.
DR InParanoid; Q8CFA7; -.
DR OMA; MMPLGEP; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8CFA7; -.
DR TreeFam; TF350556; -.
DR BioGRID-ORCS; 75753; 0 hits in 71 CRISPR screens.
DR PRO; PR:Q8CFA7; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8CFA7; protein.
DR Bgee; ENSMUSG00000048626; Expressed in animal zygote and 45 other tissues.
DR Genevisible; Q8CFA7; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:UniProtKB.
DR GO; GO:0007276; P:gamete generation; IDA:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:UniProtKB.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..341
FT /note="Krueppel-like factor 17"
FT /id="PRO_0000047556"
FT ZN_FING 256..280
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 286..310
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 316..338
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 214..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 141
FT /note="S -> G (in Ref. 5; AAH64748)"
FT /evidence="ECO:0000305"
FT CONFLICT 165
FT /note="L -> M (in Ref. 2; BAB31177)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 341 AA; 38076 MW; 03F400D4485DDE3A CRC64;
MEQDNKEQAM HQPPMDNKML VPVSNVPVSS GNSGFHQPPA TQYLPEMMRS YMASAEELRC
NEREWESQLI RSLPEHGVRC PSQLAPIPFQ NYCQRSIGRG SHVMPVGSSG TLGVTISFSE
NLMPQGGLPS SRGVSVMAHS SAPAMPYPMP PTVPATTGSL KHGILLVPGM ASAGTHAVAP
FMDQMLHSIN PCNPEMLPAR FQQLLPLDSQ DSLVTESNTQ EEPFVREPPT PAPEGAESPS
TSRGATRRQS PVSRPYVCTY NSCGKSYTKR SHLVSHQRKH TGVKPFACDW NGCTWKFFRS
DELGRHKRIH TRYRPHKCDE CDREFMRSDH LRQHKRTHLP K
