ID   KLF17_PIG               Reviewed;         387 AA.
AC   C7EMF5;
DT   15-DEC-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Krueppel-like factor 17;
GN   Name=KLF17;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=19941950; DOI=10.1016/j.ygeno.2009.11.001;
RA   Chen Z., Lei T., Chen X., Zhang J., Yu A., Long Q., Long H., Jin D.,
RA   Gan L., Yang Z.;
RT   "Porcine KLF gene family: Structure, mapping, and phylogenetic analysis.";
RL   Genomics 95:111-119(2010).
CC   -!- FUNCTION: Transcription repressor that binds to the promoter of target
CC       genes and prevents their expression. Acts as a negative regulator of
CC       epithelial-mesenchymal transition and metastasis in breast cancer.
CC       Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a
CC       key metastasis regulator in breast cancer, and repress its expression.
CC       May be a germ cell-specific transcription factor that plays important
CC       roles in spermatid differentiation and oocyte development (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Sp1 C2H2-type zinc-finger protein family.
CC       {ECO:0000305}.
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DR   EMBL; GQ274323; ACT56537.1; -; mRNA.
DR   RefSeq; NP_001157482.1; NM_001164010.1.
DR   AlphaFoldDB; C7EMF5; -.
DR   SMR; C7EMF5; -.
DR   STRING; 9823.ENSSSCP00000021547; -.
DR   PaxDb; C7EMF5; -.
DR   PRIDE; C7EMF5; -.
DR   Ensembl; ENSSSCT00000029287; ENSSSCP00000021547; ENSSSCG00000024191.
DR   Ensembl; ENSSSCT00025101948; ENSSSCP00025045072; ENSSSCG00025074015.
DR   Ensembl; ENSSSCT00035029844; ENSSSCP00035011565; ENSSSCG00035022829.
DR   Ensembl; ENSSSCT00055008930; ENSSSCP00055007072; ENSSSCG00055004528.
DR   Ensembl; ENSSSCT00065065226; ENSSSCP00065028266; ENSSSCG00065047666.
DR   GeneID; 100302639; -.
DR   KEGG; ssc:100302639; -.
DR   CTD; 128209; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000162020; -.
DR   HOGENOM; CLU_827795_0_0_1; -.
DR   InParanoid; C7EMF5; -.
DR   OMA; MMPLGEP; -.
DR   OrthoDB; 1318335at2759; -.
DR   Proteomes; UP000008227; Chromosome 6.
DR   Proteomes; UP000314985; Unplaced.
DR   Bgee; ENSSSCG00000024191; Expressed in testis and 2 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..387
FT                   /note="Krueppel-like factor 17"
FT                   /id="PRO_0000390461"
FT   ZN_FING         280..304
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         310..334
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         340..362
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          28..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          213..234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          257..277
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          357..387
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..44
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   387 AA;  42727 MW;  78EDA4298B3D3838 CRC64;
     MEQGAEGLSQ WPVAPHQFTE DTEKSLSFLD MSSSPGSGGV HTSWNRGPSG IRRVPQCPEL
     ERMSLASAQA PRQSACEMGQ QFSMSPPEHG LSYCPQMTFT ASQMVYSQGM SPSQPGMGAF
     KGAQAMPLGE PSISSVAVTF SGNLRMPPSG LPVSPPSGIP LMSHIGMPTM PYSGLPTVPF
     NGDALTPNMF LDPTMPPTEV QAVLPSLAQM LPSRDPQDFA MPPAGSPSLL PLESQGSFLS
     QPVSQEDFPK HHLCEPRREA QNSRAQERAS GRSSPVSRPY HCEYENCGKA YTKRSHLVSH
     QRKHTGERPY KCTWEACTWS FFRSDELGRH TRIHTRYRPH KCDQCGRQFM RSDHLRQHQR
     THMRMPRSPD PQADSGRRAG PLPAPHL