ID   KLF18_HUMAN             Reviewed;        1052 AA.
AC   A0A0U1RQI7;
DT   18-JUL-2018, integrated into UniProtKB/Swiss-Prot.
DT   17-FEB-2016, sequence version 1.
DT   03-AUG-2022, entry version 33.
DE   RecName: Full=Kruppel-like factor 18 {ECO:0000305};
GN   Name=KLF18 {ECO:0000312|HGNC:HGNC:51793};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; AL359839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS85967.1; -.
DR   AlphaFoldDB; A0A0U1RQI7; -.
DR   SMR; A0A0U1RQI7; -.
DR   BioMuta; KLF18; -.
DR   PeptideAtlas; A0A0U1RQI7; -.
DR   Antibodypedia; 81872; 1 antibodies from 1 providers.
DR   Ensembl; ENST00000634670.1; ENSP00000489024.1; ENSG00000283039.1.
DR   MANE-Select; ENST00000634670.1; ENSP00000489024.1; NM_001358438.1; NP_001345367.1.
DR   GeneCards; KLF18; -.
DR   HGNC; HGNC:51793; KLF18.
DR   HPA; ENSG00000283039; Not detected.
DR   neXtProt; NX_A0A0U1RQI7; -.
DR   VEuPathDB; HostDB:ENSG00000283039; -.
DR   GeneTree; ENSGT00940000164376; -.
DR   OMA; LYGEQMT; -.
DR   Pharos; A0A0U1RQI7; Tdark.
DR   PRO; PR:A0A0U1RQI7; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; A0A0U1RQI7; protein.
DR   Bgee; ENSG00000283039; Expressed in upper leg skin and 4 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 2.150.10.10; -; 2.
DR   InterPro; IPR011049; Serralysin-like_metalloprot_C.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   3: Inferred from homology;
KW   Metal-binding; Nucleus; Reference proteome; Repeat; Zinc; Zinc-finger.
FT   CHAIN           1..1052
FT                   /note="Kruppel-like factor 18"
FT                   /id="PRO_0000444870"
FT   ZN_FING         964..988
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         994..1018
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         1024..1046
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ   SEQUENCE   1052 AA;  112602 MW;  0D9CDD0BA811F4E1 CRC64;
     MDSSLLQAIE EIEKFFQHLS ERHTEQAETP DAPEPQNCMP LTAHAEESQH ESTQSKTMPP
     LGSTMMTSAC TNIPGTVLTQ DLTMHPLKAL EDLSETYSMG QKVTSFDQVK HTAGSQMTDV
     TVTPKSSPTD CQKTTITASN MTISNESSQL NTPSSDQTLN ESQIPALLGD QMKTLSDNQT
     LCGDQVTFSS DQTLTDGHTV TSGSDETLSG GQMTTSLDLY GGQMMTSIDN QTLCGEQMTT
     SSGNQAFYGR QMTTSTGNQT LCGEQMTTST GNQALYGGQM TTSASNQTLC GEQMTTSTSN
     QTLCGEQVMT STGNQALCGG QMTTSTGNQN LYGGQMMTST GNQTLYWGQM MTSTGNQNLC
     GEQVMTSTGN QALCGGQMTT STGNQNLYGG QMMTSTGNQT LYWGQMMTST GNQNLCGEQV
     MTSTGNQALC GGQMTTSTGN QNLCGEQVMT STSNQTLCGE QTTTSTSNQT LCGEQVTTST
     GNQALYGGQM MTSTGNQTLY WGQMMTSTGN QNLCGEQMTT STGNQALYGG QMTTSTSNQT
     LCGEQMTTPT SNQTLCGEQV TTSTGNQALY GGQITTSTSN QTLCGEQMTT STSNQTLCGE
     QVTTSTGNQA LYGGQMMTST GNQALYGGQM TTSASNQTLC GEQMTTSTSN QTLCEEQVMT
     STGNQALCGE QMTTSTGNQA LYGGQMTTST SNQTLCGEQT TTSTSNQTLC GEQVTTSTGN
     QALYGGQMMT STGNQTLYWG QMMTSTGNQN LCGEQMTTST GNQALYGGQM TTSTSNQTLC
     GEQMTTPTSN QTLCGEQVTT STGNQALYRG QITTSTSNQT LCGEQMTTST SNQTLCGEQV
     TTSTGNQALY GGQMMTSTGN QNLYGGQNMT STDNQALYGG QMATYSGNQT LYGDQMLTLQ
     VGNMTTLTDD HSLYGGYMMS HQFSSLPYPG FLCFSSSHLI QGQLPKQKTQ SCQFWKNPEV
     SRPYVCTYED CKMSYSKACH LRTHMRKHTG EKPYVCDVEG CTWKFARSDE LNRHKKRHTG
     ERPYLCSICS KNFARSDHLK QHAKVHNIRP GL