KLF1_SCHPO
ID KLF1_SCHPO Reviewed; 781 AA.
AC Q9US36;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 127.
DE RecName: Full=Zinc finger protein klf1;
DE AltName: Full=Krueppel-like zinc finger transcription factor 1;
GN Name=klf1; ORFNames=SPAC1039.05c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=17535257; DOI=10.1111/j.1365-2443.2007.01079.x;
RA Shimanuki M., Chung S.Y., Chikashige Y., Kawasaki Y., Uehara L.,
RA Tsutsumi C., Hatanaka M., Hiraoka Y., Nagao K., Yanagida M.;
RT "Two-step, extensive alterations in the transcriptome from G0 arrest to
RT cell division in Schizosaccharomyces pombe.";
RL Genes Cells 12:677-692(2007).
CC -!- FUNCTION: Required for maintaining cell viability in nitrogen-deficient
CC stationary phase (G0) cells. {ECO:0000269|PubMed:17535257}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}. Cytoplasm,
CC cytoskeleton, spindle {ECO:0000269|PubMed:16823372}.
CC -!- INDUCTION: Abundant in nitrogen-deficient G0 cells and rapidly
CC decreases its levels upon nitrogen replenishment.
CC {ECO:0000269|PubMed:17535257}.
CC -!- DISRUPTION PHENOTYPE: Defective in supporting the G0 state, while
CC normal under vegetative condition. {ECO:0000269|PubMed:17535257}.
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DR EMBL; CU329670; CAB63541.1; -; Genomic_DNA.
DR PIR; T50055; T50055.
DR RefSeq; NP_594996.1; NM_001020427.2.
DR AlphaFoldDB; Q9US36; -.
DR SMR; Q9US36; -.
DR BioGRID; 278181; 3.
DR STRING; 4896.SPAC1039.05c.1; -.
DR MaxQB; Q9US36; -.
DR PaxDb; Q9US36; -.
DR EnsemblFungi; SPAC1039.05c.1; SPAC1039.05c.1:pep; SPAC1039.05c.
DR GeneID; 2541685; -.
DR KEGG; spo:SPAC1039.05c; -.
DR PomBase; SPAC1039.05c; klf1.
DR VEuPathDB; FungiDB:SPAC1039.05c; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_006466_2_0_1; -.
DR InParanoid; Q9US36; -.
DR OMA; KLHERAY; -.
DR PhylomeDB; Q9US36; -.
DR PRO; PR:Q9US36; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0000785; C:chromatin; IDA:PomBase.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0072686; C:mitotic spindle; HDA:PomBase.
DR GO; GO:0005730; C:nucleolus; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISM:PomBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISM:PomBase.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:PomBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:PomBase.
DR GO; GO:0060237; P:regulation of fungal-type cell wall organization; IMP:PomBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR007219; Transcription_factor_dom_fun.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF04082; Fungal_trans; 1.
DR Pfam; PF00096; zf-C2H2; 1.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 2: Evidence at transcript level;
KW Cytoplasm; Cytoskeleton; Metal-binding; Nucleus; Reference proteome;
KW Repeat; Zinc; Zinc-finger.
FT CHAIN 1..781
FT /note="Zinc finger protein klf1"
FT /id="PRO_0000310842"
FT ZN_FING 17..41
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 47..70
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 781 AA; 89010 MW; 73E56906F7E6F234 CRC64;
MTKAKKSRAY QEGDIRYKCD FQGCTKSFTR KEHARRHFRS HTNSKAFICP HCSSSFTRSD
VLNRHVNQKH VKQNDAGSQT HPKHDKTLIS SSDQELPFPS YVEADVQDAA YTDLKSHIDQ
PILPDQPIIS DNFNEGLQSA IAQTGNNYMF TTSRRNNSIS GSITIPESDQ QINLQNKFLS
TPSIKNNANK SLSPQDSISI FGTSPFNAYQ QNTDNFVCWL FDNMEKDAPT ESVSNFTDGI
NAKQLNLMPV LDSPTIDFLS SHFRVDDKLV AKDLLSLSAY SSLIQVMNNN YQLSEEALQY
ITRSRVNLWI AHYWKDFHPR WPFLHRGTLK VDEAPVELLL AMITMGMHFV GDAFAYSIAV
SIHSTLRFSI YTHPDFKPPA SLWVYQALLI AEIFEKMTST VEQHNLSQIF HGVTIESMQN
GLSSKDTVTE KIPKNMTGTN IAQHKWHQWV DREASKRIAF FSFVLDSQHV ILFGYRPLID
ITSVGLPLLC DEALWNADSY EAWTSLLNEN DPPHFFPVLK MFLTNEHLPP KLSPWNMMIV
LHGLTTIGWI LSRENLGIVE NIMQNNGTNL KNWRILLKAS YKFWLRTYRV FFLNNGTLPL
NHPYVRGCLA TYELAHISLH TNIVALQTYA KSIVSTSRRL YASTSRYVSA WLASDDSEVS
IKHAVDMVEA FLGGDMEYDV QNETGLHRPW CLYVSTLILW AYGYVSDGRC EMLEPGNNDC
KSQLNAYLMQ MRTGLSEKAK DHVYVRSKTL PLLKCVIDVL CPARWGLLVD GVRILSKLVQ
L
