KLF2_CAEEL
ID KLF2_CAEEL Reviewed; 299 AA.
AC O62259;
DT 02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 2.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Kruppel-like factor 2 {ECO:0000305};
GN Name=klf-2 {ECO:0000312|WormBase:F53F8.1};
GN ORFNames=F53F8.1 {ECO:0000312|WormBase:F53F8.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=28261316; DOI=10.1186/s12986-017-0172-8;
RA Ling J., Brey C., Schilling M., Lateef F., Lopez-Dee Z.P., Fernandes K.,
RA Thiruchelvam K., Wang Y., Chandel K., Rau K., Parhar R., Al-Mohanna F.,
RA Gaugler R., Hashmi S.;
RT "Defective lipid metabolism associated with mutation in klf-2 and klf-3:
RT important roles of essential dietary salts in fat storage.";
RL Nutr. Metab. 14:22-22(2017).
CC -!- FUNCTION: Probable transcription factor which regulates lipid
CC metabolism. {ECO:0000269|PubMed:28261316}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed predominantly in intestine.
CC {ECO:0000269|PubMed:28261316}.
CC -!- DEVELOPMENTAL STAGE: Expressed in all developmental stages, increasing
CC gradually from embryo to larval L3 stage, decreasing in L4 and
CC stabilizing in adult stage. {ECO:0000269|PubMed:28261316}.
CC -!- INDUCTION: Expression is repressed in response to high levels of
CC dietary calcium. {ECO:0000269|PubMed:28261316}.
CC -!- DISRUPTION PHENOTYPE: Lipid contents in the intestine increase by 44%,
CC but increase is less in response to high levels of dietary calcium.
CC {ECO:0000269|PubMed:28261316}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; BX284605; CAB04459.2; -; Genomic_DNA.
DR RefSeq; NP_507995.2; NM_075594.2.
DR AlphaFoldDB; O62259; -.
DR SMR; O62259; -.
DR IntAct; O62259; 77.
DR STRING; 6239.F53F8.1; -.
DR PaxDb; O62259; -.
DR EnsemblMetazoa; F53F8.1.1; F53F8.1.1; WBGene00009998.
DR EnsemblMetazoa; F53F8.1.2; F53F8.1.2; WBGene00009998.
DR GeneID; 186179; -.
DR KEGG; cel:CELE_F53F8.1; -.
DR UCSC; F53F8.1; c. elegans.
DR CTD; 186179; -.
DR WormBase; F53F8.1; CE44073; WBGene00009998; klf-2.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_931368_0_0_1; -.
DR InParanoid; O62259; -.
DR OMA; VINVHNY; -.
DR OrthoDB; 1314812at2759; -.
DR PhylomeDB; O62259; -.
DR SignaLink; O62259; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00009998; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; IMP:UniProtKB.
DR GO; GO:0019216; P:regulation of lipid metabolic process; IMP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..299
FT /note="Kruppel-like factor 2"
FT /id="PRO_0000452531"
FT ZN_FING 198..222
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 228..252
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 258..280
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 19..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 146..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 299 AA; 34809 MW; AB780BCAF2460252 CRC64;
MYSSIVPSSS NGYYHQSQYQ NAHHQHHQQH YHQQSHHHYN GAAAAPVINV HNYHFHTGPV
NNQVIEQHYN HHNHVQQTFE ENIPQGPHSS FNFSHDFPQQ NNSETHLNHM EPSMTPMEHQ
NSGSSTPYPF EAKLFVPSPA ASVSSYSFSS DLSGKDEEDP RIPLKDRGRV YHPQSTEKPK
KVPSKRRDKA TLDRLRVHKC FYQGCGKVYT KSSHLTAHER VHSGEKPYPC EWPGCSWRFA
RSDELTRHYR KHTGAKPFAC KECSRKFSRS DHLQLHMKRH ETDEQDDGMD DFKDFMTFI
