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KLF6_HUMAN
ID   KLF6_HUMAN              Reviewed;         283 AA.
AC   Q99612; B2RE86; B4DDN0; D3DRR1; F5H3M5; Q5VUT7; Q5VUT8; Q9BT79;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 3.
DT   03-AUG-2022, entry version 204.
DE   RecName: Full=Krueppel-like factor 6;
DE   AltName: Full=B-cell-derived protein 1;
DE   AltName: Full=Core promoter element-binding protein;
DE   AltName: Full=GC-rich sites-binding factor GBF;
DE   AltName: Full=Proto-oncogene BCD1;
DE   AltName: Full=Suppressor of tumorigenicity 12 protein;
DE   AltName: Full=Transcription factor Zf9;
GN   Name=KLF6; Synonyms=BCD1, COPEB, CPBP, ST12;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   PRELIMINARY NUCLEOTIDE SEQUENCE (ISOFORM 1).
RX   PubMed=9000136;
RA   El Rouby S., Newcomb E.W.;
RT   "Identification of Bcd, a novel proto-oncogene expressed in B-cells.";
RL   Oncogene 13:2623-2630(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Placenta;
RX   PubMed=9083102; DOI=10.1074/jbc.272.14.9573;
RA   Koritschoner N.P., Bocco J.L., Panzetta-Dutari G.M., Dumur C.I., Flury A.,
RA   Patrito L.C.;
RT   "A novel human zinc finger protein that interacts with the core promoter
RT   element of a TATA box-less gene.";
RL   J. Biol. Chem. 272:9573-9580(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Hepatic stellate cell;
RX   PubMed=9689109; DOI=10.1073/pnas.95.16.9500;
RA   Ratziu V., Lalazar A., Wong L., Dang Q., Collins C., Shaulian E.,
RA   Jensen S., Friedman S.L.;
RT   "Zf9, a Kruppel-like transcription factor up-regulated in vivo during early
RT   hepatic fibrosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 95:9500-9505(1998).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND CHARACTERIZATION.
RC   TISSUE=Leukocyte;
RX   PubMed=9685731; DOI=10.1093/oxfordjournals.jbchem.a022124;
RA   Suzuki T., Yamamoto T., Kurabayashi M., Nagai R., Yazaki Y., Horikoshi M.;
RT   "Isolation and initial characterization of GBF, a novel DNA-binding zinc
RT   finger protein that binds to the GC-rich binding sites of the HIV-1
RT   promoter.";
RL   J. Biochem. 124:389-395(1998).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Koritschoner N.P.;
RT   "Genomic organization of the human COPEB/CPBP locus.";
RL   Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA   Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA   Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA   Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA   Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA   Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA   Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA   Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA   McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA   Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA   Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA   Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA   Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA   Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA   Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA   Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [9]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [10]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [11]
RP   INACTIVATION OF 9AATAD MOTIF.
RX   PubMed=31375868; DOI=10.1007/s00018-019-03251-w;
RA   Piskacek M., Havelka M., Jendruchova K., Knight A., Keegan L.P.;
RT   "The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with
RT   valines and intron reservoirs.";
RL   Cell. Mol. Life Sci. 77:1793-1810(2020).
RN   [12]
RP   INVOLVEMENT IN PC, VARIANTS ARG-64; PRO-116; ASP-123 AND PRO-169, AND
RP   CHARACTERIZATION OF VARIANTS ARG-64; PRO-116; ASP-123 AND PRO-169.
RX   PubMed=11752579; DOI=10.1126/science.1066326;
RA   Narla G., Heath K.E., Reeves H.L., Li D., Giono L.E., Kimmelman A.C.,
RA   Glucksman M.J., Narla J., Eng F.J., Chan A.M., Ferrari A.C.,
RA   Martignetti J.A., Friedman S.L.;
RT   "KLF6, a candidate tumor suppressor gene mutated in prostate cancer.";
RL   Science 294:2563-2566(2001).
RN   [13]
RP   INVOLVEMENT IN GASC, AND VARIANTS ARG-155; THR-172; LEU-180 AND LYS-198.
RX   PubMed=15824733; DOI=10.1038/sj.onc.1208670;
RA   Cho Y.G., Kim C.J., Park C.H., Yang Y.M., Kim S.Y., Nam S.W., Lee S.H.,
RA   Yoo N.J., Lee J.Y., Park W.S.;
RT   "Genetic alterations of the KLF6 gene in gastric cancer.";
RL   Oncogene 24:4588-4590(2005).
RN   [14]
RP   INTERACTION WITH ZZEF1.
RX   PubMed=33227311; DOI=10.1016/j.jmb.2020.11.021;
RA   Yu Y., Tencer A., Xuan H., Kutateladze T.G., Shi X.;
RT   "ZZEF1 is a Histone Reader and Transcriptional Coregulator of Krueppel-Like
RT   Factors.";
RL   J. Mol. Biol. 433:166722-166722(2021).
CC   -!- FUNCTION: Transcriptional activator (By similarity). Binds a GC box
CC       motif. Could play a role in B-cell growth and development.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with ZZEF1. {ECO:0000269|PubMed:33227311}.
CC   -!- INTERACTION:
CC       Q99612; P41250: GARS1; NbExp=3; IntAct=EBI-714994, EBI-724143;
CC       Q99612; P02545: LMNA; NbExp=3; IntAct=EBI-714994, EBI-351935;
CC       Q99612; Q04206: RELA; NbExp=6; IntAct=EBI-714994, EBI-73886;
CC       Q99612; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-714994, EBI-5235340;
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q99612-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q99612-2; Sequence=VSP_015715;
CC       Name=3;
CC         IsoId=Q99612-3; Sequence=VSP_045808;
CC   -!- TISSUE SPECIFICITY: Highly expressed in placenta followed by spleen,
CC       thymus, prostate, testis, small intestine and colon. Weakly expressed
CC       in pancreas, lung, liver, heart and skeletal muscle. Also expressed in
CC       fetal brain, spleen and thymus.
CC   -!- DOMAIN: The acidic N-terminal part may favor interaction with the basic
CC       domain of transcription factors.
CC   -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large
CC       number of yeast and animal transcription factors. In KLF6, the motif is
CC       inactive. {ECO:0000269|PubMed:31375868}.
CC   -!- DISEASE: Gastric cancer (GASC) [MIM:613659]: A malignant disease which
CC       starts in the stomach, can spread to the esophagus or the small
CC       intestine, and can extend through the stomach wall to nearby lymph
CC       nodes and organs. It also can metastasize to other parts of the body.
CC       The term gastric cancer or gastric carcinoma refers to adenocarcinoma
CC       of the stomach that accounts for most of all gastric malignant tumors.
CC       Two main histologic types are recognized, diffuse type and intestinal
CC       type carcinomas. Diffuse tumors are poorly differentiated infiltrating
CC       lesions, resulting in thickening of the stomach. In contrast,
CC       intestinal tumors are usually exophytic, often ulcerating, and
CC       associated with intestinal metaplasia of the stomach, most often
CC       observed in sporadic disease. {ECO:0000269|PubMed:15824733}. Note=The
CC       disease is caused by variants affecting the gene represented in this
CC       entry.
CC   -!- DISEASE: Prostate cancer (PC) [MIM:176807]: A malignancy originating in
CC       tissues of the prostate. Most prostate cancers are adenocarcinomas that
CC       develop in the acini of the prostatic ducts. Other rare histopathologic
CC       types of prostate cancer that occur in approximately 5% of patients
CC       include small cell carcinoma, mucinous carcinoma, prostatic ductal
CC       carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal
CC       cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell
CC       carcinoma and neuroendocrine carcinoma. {ECO:0000269|PubMed:11752579}.
CC       Note=The disease is caused by variants affecting the gene represented
CC       in this entry.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC23699.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAA33050.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC       Haematology;
CC       URL="http://atlasgeneticsoncology.org/Genes/KLF6ID44002ch10p15.html";
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DR   EMBL; U44975; AAC23699.1; ALT_INIT; mRNA.
DR   EMBL; AF001461; AAC39929.1; -; mRNA.
DR   EMBL; AB017493; BAA33050.1; ALT_INIT; mRNA.
DR   EMBL; AF284036; AAM73548.1; -; Genomic_DNA.
DR   EMBL; BT006778; AAP35424.1; -; mRNA.
DR   EMBL; AL513303; CAH74049.1; -; Genomic_DNA.
DR   EMBL; AL450322; CAH74049.1; JOINED; Genomic_DNA.
DR   EMBL; AK293259; BAG56791.1; -; mRNA.
DR   EMBL; AK316596; BAG38183.1; -; mRNA.
DR   EMBL; AL513303; CAH74050.1; -; Genomic_DNA.
DR   EMBL; AL450322; CAH74050.1; JOINED; Genomic_DNA.
DR   EMBL; AL450322; CAH71010.1; -; Genomic_DNA.
DR   EMBL; AL513303; CAH71010.1; JOINED; Genomic_DNA.
DR   EMBL; AL450322; CAH71011.1; -; Genomic_DNA.
DR   EMBL; AL513303; CAH71011.1; JOINED; Genomic_DNA.
DR   EMBL; CH471072; EAW86477.1; -; Genomic_DNA.
DR   EMBL; CH471072; EAW86479.1; -; Genomic_DNA.
DR   EMBL; BC000311; AAH00311.1; -; mRNA.
DR   CCDS; CCDS53490.1; -. [Q99612-3]
DR   CCDS; CCDS7060.1; -. [Q99612-1]
DR   PIR; JE0235; JE0235.
DR   RefSeq; NP_001153596.1; NM_001160124.1.
DR   RefSeq; NP_001153597.1; NM_001160125.1. [Q99612-3]
DR   RefSeq; NP_001291.3; NM_001300.5. [Q99612-1]
DR   AlphaFoldDB; Q99612; -.
DR   SMR; Q99612; -.
DR   BioGRID; 107711; 93.
DR   IntAct; Q99612; 81.
DR   STRING; 9606.ENSP00000419923; -.
DR   iPTMnet; Q99612; -.
DR   PhosphoSitePlus; Q99612; -.
DR   BioMuta; KLF6; -.
DR   DMDM; 7387592; -.
DR   EPD; Q99612; -.
DR   jPOST; Q99612; -.
DR   MassIVE; Q99612; -.
DR   MaxQB; Q99612; -.
DR   PaxDb; Q99612; -.
DR   PeptideAtlas; Q99612; -.
DR   PRIDE; Q99612; -.
DR   ProteomicsDB; 26317; -.
DR   ProteomicsDB; 78355; -. [Q99612-1]
DR   ProteomicsDB; 78356; -. [Q99612-2]
DR   Antibodypedia; 4619; 229 antibodies from 36 providers.
DR   DNASU; 1316; -.
DR   Ensembl; ENST00000469435.1; ENSP00000419079.1; ENSG00000067082.15. [Q99612-2]
DR   Ensembl; ENST00000497571.6; ENSP00000419923.1; ENSG00000067082.15. [Q99612-1]
DR   Ensembl; ENST00000542957.1; ENSP00000445301.1; ENSG00000067082.15. [Q99612-3]
DR   GeneID; 1316; -.
DR   KEGG; hsa:1316; -.
DR   MANE-Select; ENST00000497571.6; ENSP00000419923.1; NM_001300.6; NP_001291.3.
DR   UCSC; uc001iha.4; human. [Q99612-1]
DR   CTD; 1316; -.
DR   DisGeNET; 1316; -.
DR   GeneCards; KLF6; -.
DR   HGNC; HGNC:2235; KLF6.
DR   HPA; ENSG00000067082; Tissue enhanced (bone).
DR   MalaCards; KLF6; -.
DR   MIM; 176807; phenotype.
DR   MIM; 602053; gene.
DR   MIM; 613659; phenotype.
DR   neXtProt; NX_Q99612; -.
DR   OpenTargets; ENSG00000067082; -.
DR   PharmGKB; PA26751; -.
DR   VEuPathDB; HostDB:ENSG00000067082; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000158085; -.
DR   HOGENOM; CLU_002678_33_4_1; -.
DR   InParanoid; Q99612; -.
DR   OMA; LWNCTPG; -.
DR   OrthoDB; 982312at2759; -.
DR   PhylomeDB; Q99612; -.
DR   TreeFam; TF350556; -.
DR   PathwayCommons; Q99612; -.
DR   SignaLink; Q99612; -.
DR   SIGNOR; Q99612; -.
DR   BioGRID-ORCS; 1316; 29 hits in 1108 CRISPR screens.
DR   ChiTaRS; KLF6; human.
DR   GeneWiki; KLF6; -.
DR   GenomeRNAi; 1316; -.
DR   Pharos; Q99612; Tbio.
DR   PRO; PR:Q99612; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   RNAct; Q99612; protein.
DR   Bgee; ENSG00000067082; Expressed in nipple and 212 other tissues.
DR   Genevisible; Q99612; HS.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005829; C:cytosol; IDA:HPA.
DR   GO; GO:0001650; C:fibrillar center; IDA:HPA.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR   GO; GO:0005730; C:nucleolus; IDA:HPA.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0005634; C:nucleus; TAS:UniProtKB.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR   GO; GO:0030183; P:B cell differentiation; NAS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; TAS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   1: Evidence at protein level;
KW   Activator; Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..283
FT                   /note="Krueppel-like factor 6"
FT                   /id="PRO_0000047171"
FT   ZN_FING         200..224
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         230..254
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         260..282
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          106..198
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           62..70
FT                   /note="9aaTAD; inactive"
FT                   /evidence="ECO:0000269|PubMed:31375868"
FT   COMPBIAS        106..123
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        136..157
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         227..283
FT                   /note="EKPYRCSWEGCEWRFARSDELTRHFRKHTGAKPFKCSHCDRCFSRSDHLALH
FT                   MKRHL -> QCPRGPRRAAAGGRHCIAPALEGAGPGCTGCGQGRQILTSSDVFHQSIRS
FT                   FWSSE (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_015715"
FT   VAR_SEQ         227..283
FT                   /note="EKPYRCSWEGCEWRFARSDELTRHFRKHTGAKPFKCSHCDRCFSRSDHLALH
FT                   MKRHL -> VFPGLTTWPCT (in isoform 3)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_045808"
FT   VARIANT         64
FT                   /note="W -> R (found in prostate cancer samples; somatic
FT                   mutation; does not up-regulates CDKN1A in a p53-independent
FT                   manner and significantly reduces cell proliferation;
FT                   dbSNP:rs121909142)"
FT                   /evidence="ECO:0000269|PubMed:11752579"
FT                   /id="VAR_065136"
FT   VARIANT         116
FT                   /note="S -> P (found in prostate cancer samples; somatic
FT                   mutation; does not up-regulates CDKN1A in a p53-independent
FT                   manner and significantly reduces cell proliferation;
FT                   dbSNP:rs121909139)"
FT                   /evidence="ECO:0000269|PubMed:11752579"
FT                   /id="VAR_065137"
FT   VARIANT         123
FT                   /note="A -> D (found in prostate cancer samples; somatic
FT                   mutation; does not up-regulates CDKN1A in a p53-independent
FT                   manner and significantly reduces cell proliferation;
FT                   dbSNP:rs121909141)"
FT                   /evidence="ECO:0000269|PubMed:11752579"
FT                   /id="VAR_065138"
FT   VARIANT         155
FT                   /note="S -> R (found in gastric cancer samples; somatic
FT                   mutation; dbSNP:rs121909144)"
FT                   /evidence="ECO:0000269|PubMed:15824733"
FT                   /id="VAR_065139"
FT   VARIANT         169
FT                   /note="L -> P (found in prostate cancer samples; somatic
FT                   mutation; does not up-regulates CDKN1A in a p53-independent
FT                   manner and significantly reduces cell proliferation;
FT                   dbSNP:rs121909143)"
FT                   /evidence="ECO:0000269|PubMed:11752579"
FT                   /id="VAR_065140"
FT   VARIANT         172
FT                   /note="P -> T (found in gastric cancer samples; somatic
FT                   mutation)"
FT                   /evidence="ECO:0000269|PubMed:15824733"
FT                   /id="VAR_065141"
FT   VARIANT         180
FT                   /note="S -> L (found in gastric cancer samples; somatic
FT                   mutation; dbSNP:rs372338890)"
FT                   /evidence="ECO:0000269|PubMed:15824733"
FT                   /id="VAR_065142"
FT   VARIANT         198
FT                   /note="R -> K (found in gastric cancer samples; somatic
FT                   mutation)"
FT                   /evidence="ECO:0000269|PubMed:15824733"
FT                   /id="VAR_065143"
FT   CONFLICT        276
FT                   /note="A -> G (in Ref. 3; AAC39929)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   283 AA;  31865 MW;  84294A7E6D0A0231 CRC64;
     MDVLPMCSIF QELQIVHETG YFSALPSLEE YWQQTCLELE RYLQSEPCYV SASEIKFDSQ
     EDLWTKIILA REKKEESELK ISSSPPEDTL ISPSFCYNLE TNSLNSDVSS ESSDSSEELS
     PTAKFTSDPI GEVLVSSGKL SSSVTSTPPS SPELSREPSQ LWGCVPGELP SPGKVRSGTS
     GKPGDKGNGD ASPDGRRRVH RCHFNGCRKV YTKSSHLKAH QRTHTGEKPY RCSWEGCEWR
     FARSDELTRH FRKHTGAKPF KCSHCDRCFS RSDHLALHMK RHL
 
 
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