KLF6_HUMAN
ID KLF6_HUMAN Reviewed; 283 AA.
AC Q99612; B2RE86; B4DDN0; D3DRR1; F5H3M5; Q5VUT7; Q5VUT8; Q9BT79;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 3.
DT 03-AUG-2022, entry version 204.
DE RecName: Full=Krueppel-like factor 6;
DE AltName: Full=B-cell-derived protein 1;
DE AltName: Full=Core promoter element-binding protein;
DE AltName: Full=GC-rich sites-binding factor GBF;
DE AltName: Full=Proto-oncogene BCD1;
DE AltName: Full=Suppressor of tumorigenicity 12 protein;
DE AltName: Full=Transcription factor Zf9;
GN Name=KLF6; Synonyms=BCD1, COPEB, CPBP, ST12;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP PRELIMINARY NUCLEOTIDE SEQUENCE (ISOFORM 1).
RX PubMed=9000136;
RA El Rouby S., Newcomb E.W.;
RT "Identification of Bcd, a novel proto-oncogene expressed in B-cells.";
RL Oncogene 13:2623-2630(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=9083102; DOI=10.1074/jbc.272.14.9573;
RA Koritschoner N.P., Bocco J.L., Panzetta-Dutari G.M., Dumur C.I., Flury A.,
RA Patrito L.C.;
RT "A novel human zinc finger protein that interacts with the core promoter
RT element of a TATA box-less gene.";
RL J. Biol. Chem. 272:9573-9580(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Hepatic stellate cell;
RX PubMed=9689109; DOI=10.1073/pnas.95.16.9500;
RA Ratziu V., Lalazar A., Wong L., Dang Q., Collins C., Shaulian E.,
RA Jensen S., Friedman S.L.;
RT "Zf9, a Kruppel-like transcription factor up-regulated in vivo during early
RT hepatic fibrosis.";
RL Proc. Natl. Acad. Sci. U.S.A. 95:9500-9505(1998).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND CHARACTERIZATION.
RC TISSUE=Leukocyte;
RX PubMed=9685731; DOI=10.1093/oxfordjournals.jbchem.a022124;
RA Suzuki T., Yamamoto T., Kurabayashi M., Nagai R., Yazaki Y., Horikoshi M.;
RT "Isolation and initial characterization of GBF, a novel DNA-binding zinc
RT finger protein that binds to the GC-rich binding sites of the HIV-1
RT promoter.";
RL J. Biochem. 124:389-395(1998).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Koritschoner N.P.;
RT "Genomic organization of the human COPEB/CPBP locus.";
RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [10]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [11]
RP INACTIVATION OF 9AATAD MOTIF.
RX PubMed=31375868; DOI=10.1007/s00018-019-03251-w;
RA Piskacek M., Havelka M., Jendruchova K., Knight A., Keegan L.P.;
RT "The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with
RT valines and intron reservoirs.";
RL Cell. Mol. Life Sci. 77:1793-1810(2020).
RN [12]
RP INVOLVEMENT IN PC, VARIANTS ARG-64; PRO-116; ASP-123 AND PRO-169, AND
RP CHARACTERIZATION OF VARIANTS ARG-64; PRO-116; ASP-123 AND PRO-169.
RX PubMed=11752579; DOI=10.1126/science.1066326;
RA Narla G., Heath K.E., Reeves H.L., Li D., Giono L.E., Kimmelman A.C.,
RA Glucksman M.J., Narla J., Eng F.J., Chan A.M., Ferrari A.C.,
RA Martignetti J.A., Friedman S.L.;
RT "KLF6, a candidate tumor suppressor gene mutated in prostate cancer.";
RL Science 294:2563-2566(2001).
RN [13]
RP INVOLVEMENT IN GASC, AND VARIANTS ARG-155; THR-172; LEU-180 AND LYS-198.
RX PubMed=15824733; DOI=10.1038/sj.onc.1208670;
RA Cho Y.G., Kim C.J., Park C.H., Yang Y.M., Kim S.Y., Nam S.W., Lee S.H.,
RA Yoo N.J., Lee J.Y., Park W.S.;
RT "Genetic alterations of the KLF6 gene in gastric cancer.";
RL Oncogene 24:4588-4590(2005).
RN [14]
RP INTERACTION WITH ZZEF1.
RX PubMed=33227311; DOI=10.1016/j.jmb.2020.11.021;
RA Yu Y., Tencer A., Xuan H., Kutateladze T.G., Shi X.;
RT "ZZEF1 is a Histone Reader and Transcriptional Coregulator of Krueppel-Like
RT Factors.";
RL J. Mol. Biol. 433:166722-166722(2021).
CC -!- FUNCTION: Transcriptional activator (By similarity). Binds a GC box
CC motif. Could play a role in B-cell growth and development.
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with ZZEF1. {ECO:0000269|PubMed:33227311}.
CC -!- INTERACTION:
CC Q99612; P41250: GARS1; NbExp=3; IntAct=EBI-714994, EBI-724143;
CC Q99612; P02545: LMNA; NbExp=3; IntAct=EBI-714994, EBI-351935;
CC Q99612; Q04206: RELA; NbExp=6; IntAct=EBI-714994, EBI-73886;
CC Q99612; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-714994, EBI-5235340;
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q99612-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q99612-2; Sequence=VSP_015715;
CC Name=3;
CC IsoId=Q99612-3; Sequence=VSP_045808;
CC -!- TISSUE SPECIFICITY: Highly expressed in placenta followed by spleen,
CC thymus, prostate, testis, small intestine and colon. Weakly expressed
CC in pancreas, lung, liver, heart and skeletal muscle. Also expressed in
CC fetal brain, spleen and thymus.
CC -!- DOMAIN: The acidic N-terminal part may favor interaction with the basic
CC domain of transcription factors.
CC -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large
CC number of yeast and animal transcription factors. In KLF6, the motif is
CC inactive. {ECO:0000269|PubMed:31375868}.
CC -!- DISEASE: Gastric cancer (GASC) [MIM:613659]: A malignant disease which
CC starts in the stomach, can spread to the esophagus or the small
CC intestine, and can extend through the stomach wall to nearby lymph
CC nodes and organs. It also can metastasize to other parts of the body.
CC The term gastric cancer or gastric carcinoma refers to adenocarcinoma
CC of the stomach that accounts for most of all gastric malignant tumors.
CC Two main histologic types are recognized, diffuse type and intestinal
CC type carcinomas. Diffuse tumors are poorly differentiated infiltrating
CC lesions, resulting in thickening of the stomach. In contrast,
CC intestinal tumors are usually exophytic, often ulcerating, and
CC associated with intestinal metaplasia of the stomach, most often
CC observed in sporadic disease. {ECO:0000269|PubMed:15824733}. Note=The
CC disease is caused by variants affecting the gene represented in this
CC entry.
CC -!- DISEASE: Prostate cancer (PC) [MIM:176807]: A malignancy originating in
CC tissues of the prostate. Most prostate cancers are adenocarcinomas that
CC develop in the acini of the prostatic ducts. Other rare histopathologic
CC types of prostate cancer that occur in approximately 5% of patients
CC include small cell carcinoma, mucinous carcinoma, prostatic ductal
CC carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal
CC cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell
CC carcinoma and neuroendocrine carcinoma. {ECO:0000269|PubMed:11752579}.
CC Note=The disease is caused by variants affecting the gene represented
CC in this entry.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC23699.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAA33050.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/KLF6ID44002ch10p15.html";
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DR EMBL; U44975; AAC23699.1; ALT_INIT; mRNA.
DR EMBL; AF001461; AAC39929.1; -; mRNA.
DR EMBL; AB017493; BAA33050.1; ALT_INIT; mRNA.
DR EMBL; AF284036; AAM73548.1; -; Genomic_DNA.
DR EMBL; BT006778; AAP35424.1; -; mRNA.
DR EMBL; AL513303; CAH74049.1; -; Genomic_DNA.
DR EMBL; AL450322; CAH74049.1; JOINED; Genomic_DNA.
DR EMBL; AK293259; BAG56791.1; -; mRNA.
DR EMBL; AK316596; BAG38183.1; -; mRNA.
DR EMBL; AL513303; CAH74050.1; -; Genomic_DNA.
DR EMBL; AL450322; CAH74050.1; JOINED; Genomic_DNA.
DR EMBL; AL450322; CAH71010.1; -; Genomic_DNA.
DR EMBL; AL513303; CAH71010.1; JOINED; Genomic_DNA.
DR EMBL; AL450322; CAH71011.1; -; Genomic_DNA.
DR EMBL; AL513303; CAH71011.1; JOINED; Genomic_DNA.
DR EMBL; CH471072; EAW86477.1; -; Genomic_DNA.
DR EMBL; CH471072; EAW86479.1; -; Genomic_DNA.
DR EMBL; BC000311; AAH00311.1; -; mRNA.
DR CCDS; CCDS53490.1; -. [Q99612-3]
DR CCDS; CCDS7060.1; -. [Q99612-1]
DR PIR; JE0235; JE0235.
DR RefSeq; NP_001153596.1; NM_001160124.1.
DR RefSeq; NP_001153597.1; NM_001160125.1. [Q99612-3]
DR RefSeq; NP_001291.3; NM_001300.5. [Q99612-1]
DR AlphaFoldDB; Q99612; -.
DR SMR; Q99612; -.
DR BioGRID; 107711; 93.
DR IntAct; Q99612; 81.
DR STRING; 9606.ENSP00000419923; -.
DR iPTMnet; Q99612; -.
DR PhosphoSitePlus; Q99612; -.
DR BioMuta; KLF6; -.
DR DMDM; 7387592; -.
DR EPD; Q99612; -.
DR jPOST; Q99612; -.
DR MassIVE; Q99612; -.
DR MaxQB; Q99612; -.
DR PaxDb; Q99612; -.
DR PeptideAtlas; Q99612; -.
DR PRIDE; Q99612; -.
DR ProteomicsDB; 26317; -.
DR ProteomicsDB; 78355; -. [Q99612-1]
DR ProteomicsDB; 78356; -. [Q99612-2]
DR Antibodypedia; 4619; 229 antibodies from 36 providers.
DR DNASU; 1316; -.
DR Ensembl; ENST00000469435.1; ENSP00000419079.1; ENSG00000067082.15. [Q99612-2]
DR Ensembl; ENST00000497571.6; ENSP00000419923.1; ENSG00000067082.15. [Q99612-1]
DR Ensembl; ENST00000542957.1; ENSP00000445301.1; ENSG00000067082.15. [Q99612-3]
DR GeneID; 1316; -.
DR KEGG; hsa:1316; -.
DR MANE-Select; ENST00000497571.6; ENSP00000419923.1; NM_001300.6; NP_001291.3.
DR UCSC; uc001iha.4; human. [Q99612-1]
DR CTD; 1316; -.
DR DisGeNET; 1316; -.
DR GeneCards; KLF6; -.
DR HGNC; HGNC:2235; KLF6.
DR HPA; ENSG00000067082; Tissue enhanced (bone).
DR MalaCards; KLF6; -.
DR MIM; 176807; phenotype.
DR MIM; 602053; gene.
DR MIM; 613659; phenotype.
DR neXtProt; NX_Q99612; -.
DR OpenTargets; ENSG00000067082; -.
DR PharmGKB; PA26751; -.
DR VEuPathDB; HostDB:ENSG00000067082; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000158085; -.
DR HOGENOM; CLU_002678_33_4_1; -.
DR InParanoid; Q99612; -.
DR OMA; LWNCTPG; -.
DR OrthoDB; 982312at2759; -.
DR PhylomeDB; Q99612; -.
DR TreeFam; TF350556; -.
DR PathwayCommons; Q99612; -.
DR SignaLink; Q99612; -.
DR SIGNOR; Q99612; -.
DR BioGRID-ORCS; 1316; 29 hits in 1108 CRISPR screens.
DR ChiTaRS; KLF6; human.
DR GeneWiki; KLF6; -.
DR GenomeRNAi; 1316; -.
DR Pharos; Q99612; Tbio.
DR PRO; PR:Q99612; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q99612; protein.
DR Bgee; ENSG00000067082; Expressed in nipple and 212 other tissues.
DR Genevisible; Q99612; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0001650; C:fibrillar center; IDA:HPA.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR GO; GO:0005730; C:nucleolus; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; TAS:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0030183; P:B cell differentiation; NAS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; TAS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 1: Evidence at protein level;
KW Activator; Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..283
FT /note="Krueppel-like factor 6"
FT /id="PRO_0000047171"
FT ZN_FING 200..224
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 230..254
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 260..282
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 106..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 62..70
FT /note="9aaTAD; inactive"
FT /evidence="ECO:0000269|PubMed:31375868"
FT COMPBIAS 106..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 227..283
FT /note="EKPYRCSWEGCEWRFARSDELTRHFRKHTGAKPFKCSHCDRCFSRSDHLALH
FT MKRHL -> QCPRGPRRAAAGGRHCIAPALEGAGPGCTGCGQGRQILTSSDVFHQSIRS
FT FWSSE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_015715"
FT VAR_SEQ 227..283
FT /note="EKPYRCSWEGCEWRFARSDELTRHFRKHTGAKPFKCSHCDRCFSRSDHLALH
FT MKRHL -> VFPGLTTWPCT (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_045808"
FT VARIANT 64
FT /note="W -> R (found in prostate cancer samples; somatic
FT mutation; does not up-regulates CDKN1A in a p53-independent
FT manner and significantly reduces cell proliferation;
FT dbSNP:rs121909142)"
FT /evidence="ECO:0000269|PubMed:11752579"
FT /id="VAR_065136"
FT VARIANT 116
FT /note="S -> P (found in prostate cancer samples; somatic
FT mutation; does not up-regulates CDKN1A in a p53-independent
FT manner and significantly reduces cell proliferation;
FT dbSNP:rs121909139)"
FT /evidence="ECO:0000269|PubMed:11752579"
FT /id="VAR_065137"
FT VARIANT 123
FT /note="A -> D (found in prostate cancer samples; somatic
FT mutation; does not up-regulates CDKN1A in a p53-independent
FT manner and significantly reduces cell proliferation;
FT dbSNP:rs121909141)"
FT /evidence="ECO:0000269|PubMed:11752579"
FT /id="VAR_065138"
FT VARIANT 155
FT /note="S -> R (found in gastric cancer samples; somatic
FT mutation; dbSNP:rs121909144)"
FT /evidence="ECO:0000269|PubMed:15824733"
FT /id="VAR_065139"
FT VARIANT 169
FT /note="L -> P (found in prostate cancer samples; somatic
FT mutation; does not up-regulates CDKN1A in a p53-independent
FT manner and significantly reduces cell proliferation;
FT dbSNP:rs121909143)"
FT /evidence="ECO:0000269|PubMed:11752579"
FT /id="VAR_065140"
FT VARIANT 172
FT /note="P -> T (found in gastric cancer samples; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:15824733"
FT /id="VAR_065141"
FT VARIANT 180
FT /note="S -> L (found in gastric cancer samples; somatic
FT mutation; dbSNP:rs372338890)"
FT /evidence="ECO:0000269|PubMed:15824733"
FT /id="VAR_065142"
FT VARIANT 198
FT /note="R -> K (found in gastric cancer samples; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:15824733"
FT /id="VAR_065143"
FT CONFLICT 276
FT /note="A -> G (in Ref. 3; AAC39929)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 283 AA; 31865 MW; 84294A7E6D0A0231 CRC64;
MDVLPMCSIF QELQIVHETG YFSALPSLEE YWQQTCLELE RYLQSEPCYV SASEIKFDSQ
EDLWTKIILA REKKEESELK ISSSPPEDTL ISPSFCYNLE TNSLNSDVSS ESSDSSEELS
PTAKFTSDPI GEVLVSSGKL SSSVTSTPPS SPELSREPSQ LWGCVPGELP SPGKVRSGTS
GKPGDKGNGD ASPDGRRRVH RCHFNGCRKV YTKSSHLKAH QRTHTGEKPY RCSWEGCEWR
FARSDELTRH FRKHTGAKPF KCSHCDRCFS RSDHLALHMK RHL
