KLF6_MOUSE
ID KLF6_MOUSE Reviewed; 283 AA.
AC O08584;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 3.
DT 25-MAY-2022, entry version 149.
DE RecName: Full=Krueppel-like factor 6;
DE AltName: Full=Core promoter element-binding protein;
GN Name=Klf6; Synonyms=Copeb, Cpbp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Rockefeller; TISSUE=Placenta;
RX PubMed=10570007; DOI=10.1095/biolreprod61.6.1586;
RA Slavin D., Sapin V., Lopez-Diaz F., Jacquemin P., Koritschoner N.,
RA Dastugue B., Davidson I., Chatton B., Bocco J.L.;
RT "The Kruppel-like core promoter binding protein gene is primarily expressed
RT in placenta during mouse development.";
RL Biol. Reprod. 61:1586-1591(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Swiss Webster / NIH;
RX PubMed=11274234; DOI=10.1681/asn.v124726;
RA Fischer E.A., Verpont M.C., Garrett-Sinha L.A., Ronco P.M., Rossert J.A.;
RT "Klf6 is a zinc finger protein expressed in a cell-specific manner during
RT kidney development.";
RL J. Am. Soc. Nephrol. 12:726-735(2001).
CC -!- FUNCTION: Transcriptional activator. Binds a GC box motif. Could play a
CC role in B-cell growth and development (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with ZZEF1. {ECO:0000250|UniProtKB:Q99612}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Highly expressed in placenta.
CC -!- DEVELOPMENTAL STAGE: Expression is lower in total embryos and in adult
CC tissues.
CC -!- DOMAIN: The acidic N-terminal part may favor interaction with the basic
CC domain of transcription factors.
CC -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large
CC number of yeast and animal transcription factors. In KLF6, the motif is
CC inactive. {ECO:0000250|UniProtKB:Q99612}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC99478.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF072403; AAC99478.1; ALT_INIT; mRNA.
DR EMBL; AY027436; AAK11733.1; -; mRNA.
DR AlphaFoldDB; O08584; -.
DR SMR; O08584; -.
DR STRING; 10090.ENSMUSP00000000080; -.
DR iPTMnet; O08584; -.
DR PhosphoSitePlus; O08584; -.
DR EPD; O08584; -.
DR MaxQB; O08584; -.
DR PaxDb; O08584; -.
DR PRIDE; O08584; -.
DR ProteomicsDB; 263620; -.
DR MGI; MGI:1346318; Klf6.
DR eggNOG; KOG1721; Eukaryota.
DR InParanoid; O08584; -.
DR PhylomeDB; O08584; -.
DR ChiTaRS; Klf6; mouse.
DR PRO; PR:O08584; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; O08584; protein.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0001650; C:fibrillar center; ISO:MGI.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0003677; F:DNA binding; ISS:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0003690; F:double-stranded DNA binding; ISO:MGI.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IDA:MGI.
DR GO; GO:1905205; P:positive regulation of connective tissue replacement; IMP:BHF-UCL.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..283
FT /note="Krueppel-like factor 6"
FT /id="PRO_0000047172"
FT ZN_FING 200..224
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 230..254
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 260..282
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 104..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 62..70
FT /note="9aaTAD; inactive"
FT /evidence="ECO:0000250|UniProtKB:Q99612"
FT COMPBIAS 104..158
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 283 AA; 31877 MW; 8ACF664A9C6697FC CRC64;
MDVLPMCSIF QELQIVHETG YFSALPSLEE YWQQTCLELE RYLQSEPCYV SASEIKFDSQ
EDLWTKFILA REKKEESELK ISSSPPEDSL ISSSFNYNLE TNSLNSDVSS ESSDSSEELS
PTTKFTSDPI GEVLVNSGNL SSSVISTPPS SPEVNRESSQ LWGCGPGDLP SPGKVRSGTS
GKSGDKGNGD ASPDGRRRVH RCHFNGCRKV YTKSSHLKAH QRTHTGEKPY RCSWEGCEWR
FARSDELTRH FRKHTGAKPF KCSHCDRCFS RSDHLALHMK RHL
