KLF6_RAT
ID KLF6_RAT Reviewed; 283 AA.
AC O35819; Q4V8M5;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1999, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Krueppel-like factor 6;
DE AltName: Full=Core promoter element-binding protein;
DE AltName: Full=Transcription factor Zf9;
GN Name=Klf6; Synonyms=Copeb;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9689109; DOI=10.1073/pnas.95.16.9500;
RA Ratziu V., Lalazar A., Wong L., Dang Q., Collins C., Shaulian E.,
RA Jensen S., Friedman S.L.;
RT "Zf9, a Kruppel-like transcription factor up-regulated in vivo during early
RT hepatic fibrosis.";
RL Proc. Natl. Acad. Sci. U.S.A. 95:9500-9505(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Transcriptional activator. Binds a GC box motif. Could play a
CC role in B-cell growth and development (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with ZZEF1. {ECO:0000250|UniProtKB:Q99612}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- DOMAIN: The acidic N-terminal part may favor interaction with the basic
CC domain of transcription factors.
CC -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large
CC number of yeast and animal transcription factors. In KLF6, the motif is
CC inactive. {ECO:0000250|UniProtKB:Q99612}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AF001417; AAC40204.1; -; mRNA.
DR EMBL; BC097306; AAH97306.1; -; mRNA.
DR AlphaFoldDB; O35819; -.
DR SMR; O35819; -.
DR STRING; 10116.ENSRNOP00000023033; -.
DR PaxDb; O35819; -.
DR UCSC; RGD:62389; rat.
DR RGD; 62389; Klf6.
DR VEuPathDB; HostDB:ENSRNOG00000016885; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_002678_33_4_1; -.
DR InParanoid; O35819; -.
DR PhylomeDB; O35819; -.
DR PRO; PR:O35819; -.
DR Proteomes; UP000002494; Chromosome 17.
DR Bgee; ENSRNOG00000016885; Expressed in lung and 18 other tissues.
DR ExpressionAtlas; O35819; baseline and differential.
DR Genevisible; O35819; RN.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005634; C:nucleus; IDA:RGD.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:RGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0003690; F:double-stranded DNA binding; IDA:RGD.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0071409; P:cellular response to cycloheximide; IEP:RGD.
DR GO; GO:0070301; P:cellular response to hydrogen peroxide; IEP:RGD.
DR GO; GO:0071407; P:cellular response to organic cyclic compound; IEP:RGD.
DR GO; GO:1901653; P:cellular response to peptide; IEP:RGD.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; ISO:RGD.
DR GO; GO:1905205; P:positive regulation of connective tissue replacement; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0042060; P:wound healing; IEP:RGD.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..283
FT /note="Krueppel-like factor 6"
FT /id="PRO_0000047173"
FT ZN_FING 200..224
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 230..254
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 260..282
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 102..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 62..70
FT /note="9aaTAD; inactive"
FT /evidence="ECO:0000250|UniProtKB:Q99612"
FT COMPBIAS 102..158
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 283 AA; 31841 MW; AAFCF99E927C2F63 CRC64;
MDVLPMCSIF QELQIVHETG YFSALPSLEE YWQQTCLELE RYLQSEPCYV SASEIKFDNQ
EDLWTKIILA RERKEESELK ISSSPPEDSL ISSGFNYNLE TNSLNSDVSS ESSDSSEELS
PTTKFTSDPI GEVLVNSGNL SSSVISTPPS SPEVNRESSQ LWGCGPGDLP SPGKVRSGTS
GKSGDKGSGD ASPDGRRRVH RCHFNGCRKV YTKSSHLKAH QRTHTGEKPY RCSWEGCEWR
FARSDELTRH FRKHTGAKPF KCSHCDRCFS RSDHLALHMK RHL
