KLF9_PIG
ID KLF9_PIG Reviewed; 244 AA.
AC P79288; Q5I6A2;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 3.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Krueppel-like factor 9;
DE AltName: Full=Basic transcription element-binding protein 1;
DE Short=BTE-binding protein 1;
DE AltName: Full=GC-box-binding protein 1;
DE AltName: Full=Transcription factor BTEB1;
GN Name=KLF9; Synonyms=BTEB, BTEB1;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Kerkvliet J.G., Sekar N., Veldhuis J.D.;
RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 6-144.
RC TISSUE=Endometrium;
RX PubMed=9314570; DOI=10.1095/biolreprod57.4.707;
RA Wang Y., Michel F.J., Wing A., Simmen F.A., Simmen R.C.M.;
RT "Cell-type expression, immunolocalization, and deoxyribonucleic acid-
RT binding activity of basic transcription element binding transcription
RT factor, an Sp-related family member, in porcine endometrium of pregnancy.";
RL Biol. Reprod. 57:707-714(1997).
CC -!- FUNCTION: Transcription factor that binds to GC box promoter elements.
CC Selectively activates mRNA synthesis from genes containing tandem
CC repeats of GC boxes but represses genes with a single GC box. Acts as
CC an epidermal circadian transcription factor regulating keratinocyte
CC proliferation. {ECO:0000250|UniProtKB:Q13886}.
CC -!- SUBUNIT: Interacts with ZZEF1. {ECO:0000250|UniProtKB:Q13886}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13886}.
CC -!- SIMILARITY: Belongs to the Sp1 C2H2-type zinc-finger protein family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC48767.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AY850383; AAW34126.1; -; mRNA.
DR EMBL; U57346; AAC48767.1; ALT_FRAME; mRNA.
DR RefSeq; NP_001011504.1; NM_001011504.1.
DR AlphaFoldDB; P79288; -.
DR SMR; P79288; -.
DR IntAct; P79288; 1.
DR STRING; 9823.ENSSSCP00000023475; -.
DR PaxDb; P79288; -.
DR PRIDE; P79288; -.
DR Ensembl; ENSSSCT00005051953; ENSSSCP00005032103; ENSSSCG00005032529.
DR Ensembl; ENSSSCT00015107397; ENSSSCP00015045382; ENSSSCG00015079184.
DR Ensembl; ENSSSCT00025068900; ENSSSCP00025029667; ENSSSCG00025050447.
DR Ensembl; ENSSSCT00030061264; ENSSSCP00030028020; ENSSSCG00030043922.
DR Ensembl; ENSSSCT00035049713; ENSSSCP00035019880; ENSSSCG00035037510.
DR Ensembl; ENSSSCT00040093409; ENSSSCP00040041266; ENSSSCG00040068215.
DR Ensembl; ENSSSCT00045051311; ENSSSCP00045035673; ENSSSCG00045030099.
DR Ensembl; ENSSSCT00050004224; ENSSSCP00050001636; ENSSSCG00050003198.
DR Ensembl; ENSSSCT00055009044; ENSSSCP00055007162; ENSSSCG00055004595.
DR Ensembl; ENSSSCT00060044512; ENSSSCP00060018982; ENSSSCG00060032877.
DR Ensembl; ENSSSCT00065068706; ENSSSCP00065029923; ENSSSCG00065050158.
DR Ensembl; ENSSSCT00070057476; ENSSSCP00070048864; ENSSSCG00070028638.
DR GeneID; 494562; -.
DR KEGG; ssc:494562; -.
DR CTD; 687; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_002678_33_2_1; -.
DR InParanoid; P79288; -.
DR OrthoDB; 1308225at2759; -.
DR TreeFam; TF351003; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Chromosome 1.
DR Genevisible; P79288; SS.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0071387; P:cellular response to cortisol stimulus; ISS:UniProtKB.
DR GO; GO:0010839; P:negative regulation of keratinocyte proliferation; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 2: Evidence at transcript level;
KW Biological rhythms; DNA-binding; Metal-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..244
FT /note="Krueppel-like factor 9"
FT /id="PRO_0000047156"
FT ZN_FING 143..167
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 173..197
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 203..225
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 24..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 80..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..51
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 122
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q13886"
FT CONFLICT 24
FT /note="Missing (in Ref. 2; AAC48767)"
FT /evidence="ECO:0000305"
FT CONFLICT 29
FT /note="G -> V (in Ref. 2; AAC48767)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 244 AA; 27219 MW; 771B4BFAA3C5833C CRC64;
MSAAAYMDFV AAQCLVSISN RAAVPEHGGA PDAERLRLPE REVTKEHGDP GDTWKDYCTL
VTIAKSLLDL NKYRPIQTPS VCSDSLESPD EDMGSDSDVT TESGSSPSHS PEERQDPGSA
PSPLSLLHPG VAAKGKHASE KRHKCPYSGC GKVYGKSSHL KAHYRVHTGE RPFPCTWPDC
LKKFSRSDEL TRHYRTHTGE KQFRCPLCEK RFMRSDHLTK HARRHTEFHP SMIKRSKKAL
ANPL
