KLH10_RAT
ID KLH10_RAT Reviewed; 608 AA.
AC Q6JEL3;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Kelch-like protein 10;
GN Name=Klhl10;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Testis;
RX PubMed=15136734; DOI=10.1073/pnas.0308025101;
RA Yan W., Ma L., Burns K.H., Matzuk M.M.;
RT "Haploinsufficiency of kelch-like protein homolog 10 causes infertility in
RT male mice.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7793-7798(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-501, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: May be a substrate-specific adapter of a CUL3-based E3
CC ubiquitin-protein ligase complex which mediates the ubiquitination and
CC subsequent proteasomal degradation of target proteins during
CC spermatogenesis.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Self-associates. Interacts with CUL3; indicative for the
CC participation in an E3 ubiquitin ligase complex (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR EMBL; AY495338; AAS91791.1; -; mRNA.
DR EMBL; BC085842; AAH85842.1; -; mRNA.
DR RefSeq; NP_001001510.1; NM_001001510.1.
DR AlphaFoldDB; Q6JEL3; -.
DR SMR; Q6JEL3; -.
DR STRING; 10116.ENSRNOP00000022687; -.
DR iPTMnet; Q6JEL3; -.
DR PhosphoSitePlus; Q6JEL3; -.
DR PaxDb; Q6JEL3; -.
DR PRIDE; Q6JEL3; -.
DR Ensembl; ENSRNOT00000022687; ENSRNOP00000022687; ENSRNOG00000016749.
DR GeneID; 303533; -.
DR KEGG; rno:303533; -.
DR UCSC; RGD:1303290; rat.
DR CTD; 317719; -.
DR RGD; 1303290; Klhl10.
DR eggNOG; KOG4441; Eukaryota.
DR GeneTree; ENSGT00940000154664; -.
DR HOGENOM; CLU_004253_14_1_1; -.
DR InParanoid; Q6JEL3; -.
DR OMA; SRMCSGE; -.
DR OrthoDB; 277265at2759; -.
DR PhylomeDB; Q6JEL3; -.
DR TreeFam; TF329218; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q6JEL3; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000016749; Expressed in testis and 2 other tissues.
DR Genevisible; Q6JEL3; RN.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0000902; P:cell morphogenesis; ISO:RGD.
DR GO; GO:0009566; P:fertilization; ISO:RGD.
DR GO; GO:0048873; P:homeostasis of number of cells within a tissue; ISO:RGD.
DR GO; GO:0048808; P:male genitalia morphogenesis; ISO:RGD.
DR GO; GO:0008584; P:male gonad development; ISO:RGD.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0007286; P:spermatid development; ISO:RGD.
DR CDD; cd18240; BTB_POZ_KLHL10; 1.
DR Gene3D; 2.120.10.80; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR030608; KLHL10_BTB/POZ.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 6.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF117281; SSF117281; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Differentiation; Kelch repeat; Phosphoprotein;
KW Reference proteome; Repeat; Spermatogenesis; Ubl conjugation pathway.
FT CHAIN 1..608
FT /note="Kelch-like protein 10"
FT /id="PRO_0000119114"
FT DOMAIN 39..106
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT REPEAT 292..339
FT /note="Kelch 1"
FT REPEAT 340..386
FT /note="Kelch 2"
FT REPEAT 388..433
FT /note="Kelch 3"
FT REPEAT 434..480
FT /note="Kelch 4"
FT REPEAT 481..527
FT /note="Kelch 5"
FT REPEAT 529..574
FT /note="Kelch 6"
FT MOD_RES 501
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
SQ SEQUENCE 608 AA; 68962 MW; D1D3F3A3BB2CDD69 CRC64;
MEMESSAAST RFHQPHMERK MSAMTCEIFN ELRLEGKLCD VVIKVNGFEF NAHKNILCSC
SSYFRALFTS GWNNTEKKVY NIPGISPDMM KLIIEYAYTR TVPITPDNVE KLLAAADQFN
IMGIVRGCCE FLKSELCLDN CIGICKFTDY YYCPELRQKA YMFILHNFEE MVKVSAEFLE
LSVTELKDII EKDELNVKQE DAVFEAILKW ISHDPQNRKQ HISVLLPKVR LALMHAEYFM
NNVKMNDYVK DSEECKPVII NALKAMYDLN MNGPSNSDFT NPLTRPRLPY AILFAIGGWS
GGSPTNAIEA YDARADRWVN VTCEEESPRA YHGAAYLKGY VYIIGGFDSV DYFNSVKRFD
PVKKTWHQVA PMHSRRCYVS VTVLSNFIYA MGGFDGYVRL NTAERYEPET NQWTLIAPMH
EQRSDASATT LYGKVYICGG FNGNECLFTA EVYNTESNQW TVIAPMRSRR SGIGVIAYGE
HVYAVGGFDG ANRLRSAEAY SPVANTWRTI PTMFNPRSNF GIEVVDDLLF VVGGFNGFTT
TFNVECYDEK TDEWYDAHDM SIYRSALSCC VVPGLANVGE YAARRDNFTG LALRDEVKYS
ASTSTLPV
