KLH11_MOUSE
ID KLH11_MOUSE Reviewed; 709 AA.
AC Q8CE33; Q3TDZ6; Q91VP6;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Kelch-like protein 11;
DE Flags: Precursor;
GN Name=Klhl11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 342-709 (ISOFORMS 1/2).
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3
CC ubiquitin-protein ligase complex that mediates the ubiquitination of
CC target proteins, leading most often to their proteasomal degradation.
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. Interacts with CUL3. Component of a cullin-RING-
CC based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (By
CC similarity). {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8CE33-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8CE33-2; Sequence=VSP_019496;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE41452.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK029101; BAC26297.1; -; mRNA.
DR EMBL; AK169910; BAE41452.1; ALT_FRAME; mRNA.
DR EMBL; BC011167; AAH11167.1; -; mRNA.
DR CCDS; CCDS25424.1; -. [Q8CE33-1]
DR RefSeq; NP_766153.1; NM_172565.2. [Q8CE33-1]
DR AlphaFoldDB; Q8CE33; -.
DR SMR; Q8CE33; -.
DR BioGRID; 229858; 7.
DR STRING; 10090.ENSMUSP00000054963; -.
DR iPTMnet; Q8CE33; -.
DR PhosphoSitePlus; Q8CE33; -.
DR EPD; Q8CE33; -.
DR MaxQB; Q8CE33; -.
DR PaxDb; Q8CE33; -.
DR PRIDE; Q8CE33; -.
DR ProteomicsDB; 263651; -. [Q8CE33-1]
DR ProteomicsDB; 263652; -. [Q8CE33-2]
DR Antibodypedia; 16791; 105 antibodies from 23 providers.
DR DNASU; 217194; -.
DR Ensembl; ENSMUST00000056665; ENSMUSP00000054963; ENSMUSG00000048732. [Q8CE33-1]
DR GeneID; 217194; -.
DR KEGG; mmu:217194; -.
DR UCSC; uc007llj.1; mouse. [Q8CE33-1]
DR CTD; 55175; -.
DR MGI; MGI:2388648; Klhl11.
DR VEuPathDB; HostDB:ENSMUSG00000048732; -.
DR eggNOG; KOG1072; Eukaryota.
DR GeneTree; ENSGT00940000159275; -.
DR HOGENOM; CLU_024322_0_0_1; -.
DR InParanoid; Q8CE33; -.
DR OMA; AVIIRYD; -.
DR PhylomeDB; Q8CE33; -.
DR TreeFam; TF331981; -.
DR Reactome; R-MMU-8951664; Neddylation.
DR Reactome; R-MMU-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR BioGRID-ORCS; 217194; 1 hit in 73 CRISPR screens.
DR PRO; PR:Q8CE33; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8CE33; protein.
DR Bgee; ENSMUSG00000048732; Expressed in cleaving embryo and 140 other tissues.
DR ExpressionAtlas; Q8CE33; baseline and differential.
DR Genevisible; Q8CE33; MM.
DR Gene3D; 2.120.10.80; -; 2.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 4.
DR SUPFAM; SSF117281; SSF117281; 2.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Kelch repeat; Phosphoprotein; Reference proteome;
KW Repeat; Signal; Ubl conjugation pathway.
FT SIGNAL 1..15
FT /evidence="ECO:0000255"
FT CHAIN 16..709
FT /note="Kelch-like protein 11"
FT /id="PRO_0000243919"
FT DOMAIN 95..171
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 206..308
FT /note="BACK"
FT REPEAT 361..408
FT /note="Kelch 1"
FT REPEAT 409..454
FT /note="Kelch 2"
FT REPEAT 456..502
FT /note="Kelch 3"
FT REPEAT 504..557
FT /note="Kelch 4"
FT REPEAT 611..662
FT /note="Kelch 5"
FT MOD_RES 466
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NVR0"
FT VAR_SEQ 1..140
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_019496"
SQ SEQUENCE 709 AA; 80429 MW; BA3DB8D4CA6FEB7A CRC64;
MAAAVAAAAA AAAAAASFQV LEMESMETAV AGSASLAAEV RGSGTVDFVT GAGISTLVDT
GGSDPGPEAE DFECSTHCSE LSWRQNEQRR QGLFCDITLC FGGAGGREFR AHRSVLAAAT
EYFTPLLSGQ FSESRSGRVE MRKWSSEPGP EPDTVEAVIE YMYTGRIRVS TGSVHEVLEL
ADRFLLIRLK EFCGEFLKKK LHLSNCVAIH SLAHMYTLSQ LALKAADMIR RNFYKVIQDE
EFYTLPFHLI RDWLSDLEIT VDSEEVLFET VLKWVQRNAE ERERYFEELF KLLRLSQMKP
TYLTRHVKPE RLVANNEVCV KLVAEAVERH ALRAENIQSG TLQQPTSQVS LLPRYGQNMD
VIMVIGGVSE GGDYLSECVG YFVDEDRWVN LPHIHNHLDG HAVAITESYV YVAGSMEPGF
AKTVERYNPN LNTWEHVCSL MTRKHSFGLT EVKGKLYSIG GHGNFSPGFK DVTVYNPELD
KWHNLESAPK ILRDVKALAI EDRFVYIAAR TPVDRDTEDG LKAVITCYDT ETRQWQDVES
LPLIDNYCFF QMSVVNSNFY QTASCCPKSY SLENEEAVRK IAGQVSDEIL ESLPPEVLSI
EGAAICYYRD DVFIIGGWKN SDDIDKQYRK EAYRYCAERK RWMLLPPMPQ PRCRATACHV
RIPYRYLHGT QRYPMPQNLM WQKDRIRQMQ EIHRHALNMR RVPSSQIEC
