ID   KLH13_BOVIN             Reviewed;         655 AA.
AC   A6QQY2;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Kelch-like protein 13;
GN   Name=KLHL13;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal brain;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3
CC       ubiquitin-protein ligase complex required for mitotic progression and
CC       cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates
CC       the ubiquitination of AURKB and controls the dynamic behavior of AURKB
CC       on mitotic chromosomes and thereby coordinates faithful mitotic
CC       progression and completion of cytokinesis (By similarity).
CC       {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Component of the BCR(KLHL9-KLHL13) E3 ubiquitin ligase
CC       complex, at least composed of CUL3, KLHL9, KLHL13 and RBX1. Interacts
CC       with AURKB (By similarity). {ECO:0000250}.
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DR   EMBL; BC150039; AAI50040.1; -; mRNA.
DR   RefSeq; NP_001095981.1; NM_001102511.1.
DR   AlphaFoldDB; A6QQY2; -.
DR   SMR; A6QQY2; -.
DR   STRING; 9913.ENSBTAP00000000639; -.
DR   PaxDb; A6QQY2; -.
DR   PRIDE; A6QQY2; -.
DR   Ensembl; ENSBTAT00000000639; ENSBTAP00000000639; ENSBTAG00000000501.
DR   Ensembl; ENSBTAT00000083192; ENSBTAP00000059010; ENSBTAG00000000501.
DR   GeneID; 528138; -.
DR   KEGG; bta:528138; -.
DR   CTD; 90293; -.
DR   VEuPathDB; HostDB:ENSBTAG00000000501; -.
DR   VGNC; VGNC:30643; KLHL13.
DR   eggNOG; KOG4441; Eukaryota.
DR   GeneTree; ENSGT00940000154359; -.
DR   HOGENOM; CLU_004253_14_3_1; -.
DR   InParanoid; A6QQY2; -.
DR   OMA; XGITHDT; -.
DR   OrthoDB; 250404at2759; -.
DR   TreeFam; TF328485; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000009136; Chromosome X.
DR   Bgee; ENSBTAG00000000501; Expressed in floor plate of diencephalon and 98 other tissues.
DR   ExpressionAtlas; A6QQY2; baseline and differential.
DR   GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0097602; F:cullin family protein binding; IBA:GO_Central.
DR   GO; GO:0047485; F:protein N-terminus binding; IEA:Ensembl.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:Ensembl.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0016567; P:protein ubiquitination; ISS:UniProtKB.
DR   GO; GO:0032465; P:regulation of cytokinesis; ISS:UniProtKB.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR017096; BTB-kelch_protein.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 5.
DR   PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 6.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Kelch repeat; Mitosis; Reference proteome;
KW   Repeat; Ubl conjugation pathway.
FT   CHAIN           1..655
FT                   /note="Kelch-like protein 13"
FT                   /id="PRO_0000378195"
FT   DOMAIN          92..161
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          196..297
FT                   /note="BACK"
FT   REPEAT          341..389
FT                   /note="Kelch 1"
FT   REPEAT          390..441
FT                   /note="Kelch 2"
FT   REPEAT          442..488
FT                   /note="Kelch 3"
FT   REPEAT          490..535
FT                   /note="Kelch 4"
FT   REPEAT          537..587
FT                   /note="Kelch 5"
FT   REPEAT          588..636
FT                   /note="Kelch 6"
SQ   SEQUENCE   655 AA;  73902 MW;  7683918333D17EFA CRC64;
     MPLKWKTSSP AIWKFPVPVL KTSRSTPLSP AYISLVEEED QHMKLSLGSS EMGLSSHLQS
     SKAGTTRIFT SNTHSSVVLQ GFDQLRLEGL LCDVTLMPGD TDDAFPVHRV MMASASDYFK
     AMFTGGMKEQ DLMCIKLHGV SKVGLRKIID FIYTAKLSLN MDNLQDTLEA ASFLQILPVL
     DFCKVFLISG VTLDNCVEVG RIANTYNLTE VDKYVNSFVL KNFPALLSTG EFLKLPFERL
     AFVLSSNSLK HCTELELFKA TCRWLRLEEP RMDFAAKLMK NIRFPLMTPQ ELINYVQTVD
     FMRTDNTCVN LLLEASNYQM MPYMQPVMQS DRTAIRSDTT HLVTLGGVLR QQLVVSKELR
     MYDEKAHEWK SLAPMDAPRY QHGIAVIGNF LYVVGGQSNY DTKGKTAVDT VFRFDPRYNK
     WMQVASLNEK RTFFHLSALK GYLYAVGGRN AAGELPTVEC YNPRTNEWTY VAKMSEPHYG
     HAGTVYGGVM YISGGITHDT FQKELMCFDP DTDKWIQKAP MTTVRGLHCM CTVGERLYVI
     GGNHFRGTSD YDDVLSCEYY SPILDQWTPI AAMLRGQSDV GVAVFENKIY VVGGYSWNNR
     CMVEIVQKYD PDKDEWHKVF DLPESLGGIR ACTLTVFPPE ETTPSPSRES PLSAP