ID   KLH13_CHICK             Reviewed;         629 AA.
AC   Q5ZLD3;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Kelch-like protein 13;
GN   Name=KLHL13; ORFNames=RCJMB04_6k12;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3
CC       ubiquitin-protein ligase complex required for mitotic progression and
CC       cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates
CC       the ubiquitination of AURKB and controls the dynamic behavior of AURKB
CC       on mitotic chromosomes and thereby coordinates faithful mitotic
CC       progression and completion of cytokinesis (By similarity).
CC       {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Component of the BCR(KLHL9-KLHL13) E3 ubiquitin ligase
CC       complex, at least composed of CUL3, KLHL9, KLHL13 and RBX1. Interacts
CC       with AURKB (By similarity). {ECO:0000250}.
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DR   EMBL; AJ719801; CAG31460.1; -; mRNA.
DR   RefSeq; NP_001026287.1; NM_001031116.1.
DR   RefSeq; XP_015133728.1; XM_015278242.1.
DR   AlphaFoldDB; Q5ZLD3; -.
DR   SMR; Q5ZLD3; -.
DR   STRING; 9031.ENSGALP00000009607; -.
DR   PaxDb; Q5ZLD3; -.
DR   Ensembl; ENSGALT00000009621; ENSGALP00000009607; ENSGALG00000005982.
DR   GeneID; 422226; -.
DR   KEGG; gga:422226; -.
DR   CTD; 55958; -.
DR   VEuPathDB; HostDB:geneid_422226; -.
DR   eggNOG; KOG4441; Eukaryota.
DR   GeneTree; ENSGT00940000154359; -.
DR   InParanoid; Q5ZLD3; -.
DR   PhylomeDB; Q5ZLD3; -.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q5ZLD3; -.
DR   Proteomes; UP000000539; Chromosome 4.
DR   Bgee; ENSGALG00000005982; Expressed in brain and 13 other tissues.
DR   ExpressionAtlas; Q5ZLD3; baseline and differential.
DR   GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0097602; F:cullin family protein binding; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0016567; P:protein ubiquitination; ISS:UniProtKB.
DR   GO; GO:0032465; P:regulation of cytokinesis; ISS:UniProtKB.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR017096; BTB-kelch_protein.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 5.
DR   PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 6.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Kelch repeat; Mitosis; Reference proteome;
KW   Repeat; Ubl conjugation pathway.
FT   CHAIN           1..629
FT                   /note="Kelch-like protein 13"
FT                   /id="PRO_0000378196"
FT   DOMAIN          66..135
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          170..271
FT                   /note="BACK"
FT   REPEAT          315..363
FT                   /note="Kelch 1"
FT   REPEAT          364..415
FT                   /note="Kelch 2"
FT   REPEAT          416..462
FT                   /note="Kelch 3"
FT   REPEAT          464..509
FT                   /note="Kelch 4"
FT   REPEAT          511..561
FT                   /note="Kelch 5"
FT   REPEAT          562..610
FT                   /note="Kelch 6"
SQ   SEQUENCE   629 AA;  70970 MW;  18070324564E8388 CRC64;
     MMWRDALSLV EEEDPHMKVS LGSSDMGVSA HLQSSKTGTT RFFTSNTHSS VVLQGFDQLR
     VEGLLCDVTL VPGDGDEVFP VHRAMMASAS DYFKAMFTGG MKEQDLMCIK LHGVNKIGLK
     KIIDFIYTAK LSLNMDNLQD TLEAASFLQI LPVLDFCKVF LISGVSLENC VEVGRIANTY
     NLTEVDKYVN NFILKNFPAL LSTGEFVKLP FERLAFVLSS NSLKHCTELE LFKAACRWLR
     FEEPRMEYAA KLMKNIRFPL MTPQDLINYV QTVDFMRTDN TCVNLLLEAS NYQMMPYMQP
     VMQSERTAIR SDSTHLVTLG GVLRQQLVVS KELRMYDEKA HEWKSLAPMD APRYQHGIAV
     IGNFLYVVGG QSNYDTKGKT AVDTVFRFDP RYNKWMQVAS LNEKRTFFHL SALKGHLYAV
     GGRNAAGELA TVECYNPRMN EWSYVAKMNE PHYGHAGTVY GGLMYISGGI THDTFQKELM
     CFDPDTDKWT QKAPMTTVRG LHCMCTVGDK LYVIGGNHFR GTSDYDDVLS CEYYSTTLDQ
     WTPIAAMLRG QSDVGVAVFE NKIYVVGGYS WNNRCMVEIV QKYDPEKDEW HKVFDLPESL
     GGIRACTLTV FPPEDNTGSP SRESPLSAP