ID   KLH14_CHICK             Reviewed;         622 AA.
AC   Q5F3N5;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Kelch-like protein 14;
GN   Name=KLHL14; ORFNames=RCJMB04_11g14;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Endoplasmic
CC       reticulum membrane {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ851615; CAH65249.1; -; mRNA.
DR   RefSeq; NP_001012884.1; NM_001012866.1.
DR   AlphaFoldDB; Q5F3N5; -.
DR   SMR; Q5F3N5; -.
DR   STRING; 9031.ENSGALP00000024458; -.
DR   PaxDb; Q5F3N5; -.
DR   GeneID; 421100; -.
DR   KEGG; gga:421100; -.
DR   CTD; 57565; -.
DR   VEuPathDB; HostDB:geneid_421100; -.
DR   eggNOG; KOG4441; Eukaryota.
DR   InParanoid; Q5F3N5; -.
DR   OrthoDB; 250404at2759; -.
DR   PhylomeDB; Q5F3N5; -.
DR   PRO; PR:Q5F3N5; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
DR   Gene3D; 2.120.10.80; -; 2.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR017096; BTB-kelch_protein.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR030584; KLHL14.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR45632:SF6; PTHR45632:SF6; 1.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 2.
DR   Pfam; PF01344; Kelch_1; 4.
DR   PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 6.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Endoplasmic reticulum; Kelch repeat; Membrane;
KW   Reference proteome; Repeat.
FT   CHAIN           1..622
FT                   /note="Kelch-like protein 14"
FT                   /id="PRO_0000119118"
FT   DOMAIN          33..145
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   REPEAT          317..366
FT                   /note="Kelch 1"
FT   REPEAT          367..418
FT                   /note="Kelch 2"
FT   REPEAT          419..465
FT                   /note="Kelch 3"
FT   REPEAT          467..512
FT                   /note="Kelch 4"
FT   REPEAT          514..564
FT                   /note="Kelch 5"
FT   REPEAT          566..614
FT                   /note="Kelch 6"
FT   REGION          73..108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        85..100
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   622 AA;  69698 MW;  05E4956222FD7043 CRC64;
     MSRSGDRTST FDPSHSDNLL HGLNLLWRKQ LFCDVTLTAQ GQQFHCHKAV LASCSQYFRS
     LFSSGGGHPH ALALGPGAQD GLGGAPPKEP PPPPQEEPGT PSSSPEDKLL ASPRAINNLV
     LQGCSSIGLR LVLEYLYTAN VTLSLDTVEE VLSVSKILHI PQVTKLCVQF LNDQISVQNY
     KQVCKIAALH GLEETKKLAN KYLVEDVLLL NFEEMRALLD SLPPPVESEL ALFQMSVLWL
     EHDRETRMQY APDLMKRLRF ALIPAPELVE RVQSVDFMRT DPVCQKLLLD AMNYHLMPFR
     QHCRQSLASR IRSNKKMLLL VGGLPPGPDR LPSNLVQYYD DEKKTWKILT IMPYNSAHHC
     VVEVENFLFV LGGEDQWNPN GKHSTNFVSR YDPRFNSWIQ LPPMQERRAS FYACRLDKNL
     YVIGGRNETG YLSSVECYNL ETNEWRYVSS LPQPLAAHAG AVHNGKIYIS GGVHNGEYVP
     WLYCYDPVMD VWARKQDMNT KRAIHTLAVM NDRLYAIGGN HLKGFSHLDV MLVECYDPKG
     DQWNILQTPI LEGRSGPGCA VLDDSIYLVG GYSWSMGAYK SSTICYSPEK GTWTELEGDV
     AEPLAGPACS TVILPACVPY NK