ID   KLH15_CHICK             Reviewed;         488 AA.
AC   Q5ZJU2;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Kelch-like protein 15;
GN   Name=KLHL15; ORFNames=RCJMB04_15l4;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Substrate-specific adapter for CUL3 E3 ubiquitin-protein
CC       ligase complex. {ECO:0000250|UniProtKB:Q96M94}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Homodimer. Interacts with CUL3.
CC       {ECO:0000250|UniProtKB:Q96M94}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96M94}.
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DR   EMBL; AJ720342; CAG32001.1; -; mRNA.
DR   RefSeq; NP_001025973.1; NM_001030802.1.
DR   AlphaFoldDB; Q5ZJU2; -.
DR   SMR; Q5ZJU2; -.
DR   STRING; 9031.ENSGALP00000026313; -.
DR   PaxDb; Q5ZJU2; -.
DR   PRIDE; Q5ZJU2; -.
DR   GeneID; 418598; -.
DR   KEGG; gga:418598; -.
DR   CTD; 80311; -.
DR   VEuPathDB; HostDB:geneid_418598; -.
DR   eggNOG; KOG4441; Eukaryota.
DR   InParanoid; Q5ZJU2; -.
DR   PhylomeDB; Q5ZJU2; -.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q5ZJU2; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0071630; P:nuclear protein quality control by the ubiquitin-proteasome system; IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR030597; KLHL15.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR45632:SF12; PTHR45632:SF12; 1.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 2.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 3.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Kelch repeat; Nucleus; Reference proteome; Repeat; Ubl conjugation pathway.
FT   CHAIN           1..488
FT                   /note="Kelch-like protein 15"
FT                   /id="PRO_0000223950"
FT   DOMAIN          31..98
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          133..237
FT                   /note="BACK"
FT   REPEAT          328..379
FT                   /note="Kelch 1"
FT   REPEAT          381..426
FT                   /note="Kelch 2"
FT   REPEAT          428..473
FT                   /note="Kelch 3"
SQ   SEQUENCE   488 AA;  56659 MW;  D5E45461DEE870F3 CRC64;
     MAGDVEGFSS SIHDTSVSAG FRALYEEGLL LDVTLVIEDH QFQAHKALLA TQSDYFRIMF
     TADMRERDQD KIHLKGLTAT GFSHVLQFMY YGTIELSMNT VHEILQAAMY VQLIEVVKFC
     CSFLLAKICL ENCAEIMRLL DDFSVNIEGV REKLDSFLLE NFVPLMSRPD FLSYLSFEKL
     MSYLDNDHLS RFPEIELYEA VQAWLRHDRR RWRHTDTIIQ NIRFCLMTPS SVFEKVKTSE
     FYRYSRQLRH EVDQAMNYFH SVHQQPLMEM KSNKIRSAKP QTAVFRGMIG HSMVNSKILL
     LHKPRVWWEL EGPQVPLRPD CLAIVNNFVF LLGGEELGPD GEFHASSKVF RYDPRQNTWL
     RMADMSVPRS EFAVGVIGRY VYAVAGRTRD ETFYSTERYD ITEDKWEFVD PYPVNKYGHE
     GTVLGNKLYI TGGITSSSTS KQVCVFDPSK EGTVEQRTRR TQVATNCWEN KCKMNYARCF
     HKMISYNA