ID   KLH15_DANRE             Reviewed;         604 AA.
AC   Q6DEL7;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Kelch-like protein 15;
GN   Name=klhl15; ORFNames=zgc:101051;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Substrate-specific adapter for an E3 ubiquitin-protein ligase
CC       complex. {ECO:0000250|UniProtKB:Q96M94}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96M94}.
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DR   EMBL; BC077093; AAH77093.1; -; mRNA.
DR   RefSeq; NP_001003580.1; NM_001003580.2.
DR   AlphaFoldDB; Q6DEL7; -.
DR   SMR; Q6DEL7; -.
DR   STRING; 7955.ENSDARP00000025618; -.
DR   PaxDb; Q6DEL7; -.
DR   GeneID; 445186; -.
DR   KEGG; dre:445186; -.
DR   CTD; 80311; -.
DR   ZFIN; ZDB-GENE-040801-99; klhl15.
DR   eggNOG; KOG4441; Eukaryota.
DR   InParanoid; Q6DEL7; -.
DR   PhylomeDB; Q6DEL7; -.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q6DEL7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0071630; P:nuclear protein quality control by the ubiquitin-proteasome system; IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR017096; BTB-kelch_protein.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR030597; KLHL15.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR45632:SF12; PTHR45632:SF12; 1.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 3.
DR   PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 5.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Kelch repeat; Nucleus; Reference proteome; Repeat; Ubl conjugation pathway.
FT   CHAIN           1..604
FT                   /note="Kelch-like protein 15"
FT                   /id="PRO_0000223951"
FT   DOMAIN          31..98
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          133..237
FT                   /note="BACK"
FT   REPEAT          328..379
FT                   /note="Kelch 1"
FT   REPEAT          381..426
FT                   /note="Kelch 2"
FT   REPEAT          428..473
FT                   /note="Kelch 3"
FT   REPEAT          489..542
FT                   /note="Kelch 4"
FT   REPEAT          544..592
FT                   /note="Kelch 5"
SQ   SEQUENCE   604 AA;  69506 MW;  17B8D0F0F627F5D1 CRC64;
     MSGDVEVYLS QVHDGSVSSG FRALYEERLL LDVTLLIEEH HFQAHKALLA TQSDYFRVMF
     TADMRERDQD KIHMKGLTAA GFGHVLRFMY YGSLELSMLT VQEILQAAMY VQLTEAVEFC
     CSFLLAKICL ENCAEVMRLL EDFSVGVEGV QEQLDAFLLE NFVPLMARPD FLSYLSLEKL
     MAYLDSDQLS RYPEIELYEA VQAWLRHDRR RWRHTDAVVQ NLRFCLMTPA NIFEKVKTSE
     FYRYSRQLRL EVDQALSYFH QVNEQPLAET KSNRIRSVRP QTAVFRGMIG HSMVNSKILL
     LHRPKVWWEL EGPQVPLRPD CLAIVNNFAF LLGGEELGPD GEFHASSKVY RYDPRQNSWL
     RMADMSVPRS EFAVGVIGKY IYAVAGRTRD ETFYSTERYD IVEDKWEFVD PYPVNKYGHE
     GTVLNGKLYI TGGITSSSTS KQVCVFDPGR EGSSEHRTRR TPILTNCWEN KSKMNYARCF
     HKMISHNGKL YVFGGVCVIL RASFESQGCP STEVYDPETD EWTILASMPI GRSGHGVAVL
     DKQIMVLGGL CYNGHYSDSI LTFDPEENKW KEDEYPRMPC KLDGLQVCSL HFPEYVLEHV
     RRCS