KLH20_CHICK
ID KLH20_CHICK Reviewed; 610 AA.
AC Q5ZKD9;
DT 10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Kelch-like protein 20;
GN Name=KLHL20; ORFNames=RCJMB04_11i2;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3
CC ubiquitin-protein ligase complex involved in interferon response and
CC anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin
CC ligase complex mediates the ubiquitination of target proteins, leading
CC to their degradation by the proteasome. It also specifically mediates
CC 'Lys-33'-linked ubiquitination (By similarity). {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Component of the BCR(KLHL20) E3 ubiquitin ligase complex, at
CC least composed of CUL3, KLHL20 and RBX1.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}.
CC Nucleus {ECO:0000250}.
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DR EMBL; AJ720145; CAG31804.1; -; mRNA.
DR RefSeq; NP_001026500.1; NM_001031329.1.
DR AlphaFoldDB; Q5ZKD9; -.
DR SMR; Q5ZKD9; -.
DR STRING; 9031.ENSGALP00000005545; -.
DR PaxDb; Q5ZKD9; -.
DR GeneID; 425091; -.
DR KEGG; gga:425091; -.
DR CTD; 27252; -.
DR VEuPathDB; HostDB:geneid_425091; -.
DR eggNOG; KOG4441; Eukaryota.
DR InParanoid; Q5ZKD9; -.
DR OrthoDB; 731760at2759; -.
DR PhylomeDB; Q5ZKD9; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q5ZKD9; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016605; C:PML body; ISS:UniProtKB.
DR GO; GO:0005802; C:trans-Golgi network; ISS:UniProtKB.
DR GO; GO:0019964; F:interferon-gamma binding; ISS:UniProtKB.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; ISS:UniProtKB.
DR GO; GO:0006895; P:Golgi to endosome transport; ISS:UniProtKB.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
DR GO; GO:1990390; P:protein K33-linked ubiquitination; ISS:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; ISS:UniProtKB.
DR Gene3D; 2.120.10.80; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR030594; KLHL17/KLHL20.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR24412:SF454; PTHR24412:SF454; 2.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 6.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF50965; SSF50965; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Kelch repeat; Nucleus; Protein transport; Reference proteome;
KW Repeat; Transport; Ubl conjugation pathway.
FT CHAIN 1..610
FT /note="Kelch-like protein 20"
FT /id="PRO_0000396629"
FT DOMAIN 68..135
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 170..273
FT /note="BACK"
FT REPEAT 320..366
FT /note="Kelch 1"
FT REPEAT 368..414
FT /note="Kelch 2"
FT REPEAT 415..461
FT /note="Kelch 3"
FT REPEAT 463..508
FT /note="Kelch 4"
FT REPEAT 510..555
FT /note="Kelch 5"
FT REPEAT 557..602
FT /note="Kelch 6"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 610 AA; 68025 MW; 2AC90F1B476C872D CRC64;
MDGKPMRRCT STRPGETGMD VTSRCTLGDP NKLPEGVPQP ARMPYISDKH PRQTLEVINL
LRKHRELCDV VLVVGAKKIY AHRVILSACS PYFRAMFTGE LAESRQTEVV IRDIDERAME
LLIDFAYTSQ ITVEEGNVQT SLPAACLLQL AEIQEACCEF LKRQLDPSNC LGIRAFADTH
SCRELLRIAD KFTQHNFQEV MESEEEFMLL PANQLIDIIS SDELNVRSEE QVFNAVMAWV
KYSIQERRPQ LPQVLQHVRL PLLSTKFLVG TVGSDPLIKS DEECRDLVDE AKNYLLLPQE
RPLMQGPRTR PRKPIRCGEV LFAVGGWCSG DAISSVERYD PQTNEWRMVA SMSKRRCGVG
VSVLDDLLYA VGGHDGSSYL NSVERYDPKT NQWSSDVAPT STCRTSVGVA VLGGYLYAVG
GQDGVSCLNI VERYDPKENK WTRVASMSTR RLGVAVAVLG GFLYAVGGSD GTSPLNTVER
YNPQENRWHT IAPMGTRRKH LGCAVYQDMI YAVGGRDDTT ELSSAERYNP RTNQWSPVVA
MTSRRSGVGL AVVNGQLMAV GGFDGTTYLK TIEVFDPDAN TWRLYGGMNY RRLGGGVGVI
KMTHCESHIW
