ID   KLH21_BOVIN             Reviewed;         597 AA.
AC   Q08DS0;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Kelch-like protein 21;
GN   Name=KLHL21;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal pons;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3
CC       ubiquitin-protein ligase complex required for efficient chromosome
CC       alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex
CC       regulates localization of the chromosomal passenger complex (CPC) from
CC       chromosomes to the spindle midzone in anaphase and mediates the
CC       ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3
CC       ubiquitin ligase complex may not lead to its degradation by the
CC       proteasome (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Component of the BCR(KLHL21) E3 ubiquitin ligase complex, at
CC       least composed of CUL3, KLHL21 and RBX1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000250}.
CC       Note=Localizes to the spindle midzone and targets CUL3 to this region.
CC       {ECO:0000250}.
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DR   EMBL; BC123594; AAI23595.1; -; mRNA.
DR   RefSeq; NP_001070279.1; NM_001076811.1.
DR   AlphaFoldDB; Q08DS0; -.
DR   SMR; Q08DS0; -.
DR   STRING; 9913.ENSBTAP00000010998; -.
DR   PaxDb; Q08DS0; -.
DR   PRIDE; Q08DS0; -.
DR   GeneID; 506632; -.
DR   KEGG; bta:506632; -.
DR   CTD; 9903; -.
DR   eggNOG; KOG4441; Eukaryota.
DR   InParanoid; Q08DS0; -.
DR   OrthoDB; 743142at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005827; C:polar microtubule; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0035853; P:chromosome passenger complex localization to spindle midzone; ISS:UniProtKB.
DR   GO; GO:0016567; P:protein ubiquitination; ISS:UniProtKB.
DR   GO; GO:0032465; P:regulation of cytokinesis; ISS:UniProtKB.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR017096; BTB-kelch_protein.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR030577; KLHL21.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR24412:SF255; PTHR24412:SF255; 1.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 2.
DR   PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 5.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Kelch repeat; Mitosis;
KW   Reference proteome; Repeat; Ubl conjugation pathway.
FT   CHAIN           1..597
FT                   /note="Kelch-like protein 21"
FT                   /id="PRO_0000326127"
FT   DOMAIN          35..103
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          138..239
FT                   /note="BACK"
FT   REPEAT          287..335
FT                   /note="Kelch 1"
FT   REPEAT          336..382
FT                   /note="Kelch 2"
FT   REPEAT          384..422
FT                   /note="Kelch 3"
FT   REPEAT          424..463
FT                   /note="Kelch 4"
FT   REPEAT          464..512
FT                   /note="Kelch 5"
FT   REPEAT          513..560
FT                   /note="Kelch 6"
FT   REGION          570..597
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   597 AA;  66563 MW;  2585D9A76A3FFEF1 CRC64;
     MERPAPLAVL PFSDPAHALS LLRGLSQLRA ERKFLDVTLE AAGGRDFPAH RAVLAAASPY
     FRAMFAGQLR ESRAERVRLH GVPPDMLQLL LDFSYTGRVA VSGDNAEPLL RAADLLQFPA
     VKEACGAFLQ QQLDLTNCLD MQDFAEAFSC AGLASAAQRF ILRHVGELGA EQLERLPLAR
     LLRYLRDDGL CVPKEEAAYQ LALRWVRADP PRRAAHWPQL LESVRLPFVR RFYLLAHVEA
     EPLVARCPPC LRLLREARDF QAARYDRHDR GPCPRMRPRP STGLAEILVL VGGCDQDCDE
     LVTVDCYNPQ TGQWRYLAEF PDHLGGGYSI VALGNDIYVT GGSDGSRLYD CVWRYNSSVN
     EWTEVAPMLK AREYHSSSVL DGLLYVVAAD STERYDHTTD SWEALQPMTY PMDNCSTTAC
     RGRLYAIGSL AGKETMVMQC YHPDMDLWSL VDCGQLPPWS FAPKTVTLNG LMYFIRDDSA
     EVDVYNPTKN EWDKIPSMNQ VHVGGSLAVL GGKLYVSGGY DNTFELSDVV EAYDPETRAW
     SVVGRLPEPT FWHGSVSIFR QFMPQTPLGG RGFELDGGSS DMDVGQPRPP QNPAELH