KLH22_XENTR
ID KLH22_XENTR Reviewed; 641 AA.
AC Q08CY1;
DT 10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Kelch-like protein 22 {ECO:0000305};
GN Name=klhl22;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=N6; TISSUE=Oviduct;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3
CC ubiquitin ligase complex. The BCR(KLHL22) ubiquitin ligase complex
CC could mediate the monoubiquitination of PLK1 and regulate its activity
CC in spindle assembly checkpoint (SAC) and chromosome segregation. The
CC BCR(KLHL22) ubiquitin ligase complex may also be responsible for the
CC ubiquitin-dependent proteasomal degradation of DEPDC5 and the
CC activation of the TORC1 pathway. {ECO:0000250|UniProtKB:Q53GT1}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000250|UniProtKB:Q53GT1}.
CC -!- SUBUNIT: Component of the BCR(KLHL22) E3 ubiquitin ligase complex, at
CC least composed of cul3, klhl22 and rbx1.
CC {ECO:0000250|UniProtKB:Q53GT1}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:Q53GT1}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome {ECO:0000250|UniProtKB:Q53GT1}.
CC Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q53GT1}.
CC Nucleus {ECO:0000250|UniProtKB:Q53GT1}. Lysosome
CC {ECO:0000250|UniProtKB:Q53GT1}.
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DR EMBL; BC124036; AAI24037.1; -; mRNA.
DR RefSeq; NP_001072910.1; NM_001079442.1.
DR RefSeq; XP_012821760.1; XM_012966306.2.
DR RefSeq; XP_012821764.1; XM_012966310.2.
DR AlphaFoldDB; Q08CY1; -.
DR SMR; Q08CY1; -.
DR STRING; 8364.ENSXETP00000009275; -.
DR PaxDb; Q08CY1; -.
DR DNASU; 780372; -.
DR GeneID; 780372; -.
DR KEGG; xtr:780372; -.
DR CTD; 84861; -.
DR Xenbase; XB-GENE-948974; klhl22.
DR eggNOG; KOG4441; Eukaryota.
DR HOGENOM; CLU_004253_14_3_1; -.
DR InParanoid; Q08CY1; -.
DR OrthoDB; 250404at2759; -.
DR Reactome; R-XTR-8951664; Neddylation.
DR Reactome; R-XTR-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000008143; Chromosome 1.
DR Proteomes; UP000790000; Unplaced.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0072686; C:mitotic spindle; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005827; C:polar microtubule; ISS:UniProtKB.
DR GO; GO:0051301; P:cell division; ISS:UniProtKB.
DR GO; GO:0000070; P:mitotic sister chromatid segregation; ISS:UniProtKB.
DR GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; ISS:UniProtKB.
DR GO; GO:1904263; P:positive regulation of TORC1 signaling; IBA:GO_Central.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR GO; GO:0006513; P:protein monoubiquitination; ISS:UniProtKB.
DR Gene3D; 2.120.10.80; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR030575; KLHL22.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR45632:SF5; PTHR45632:SF5; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 3.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF117281; SSF117281; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Kelch repeat; Lysosome;
KW Mitosis; Nucleus; Reference proteome; Repeat; Ubl conjugation pathway.
FT CHAIN 1..641
FT /note="Kelch-like protein 22"
FT /id="PRO_0000396636"
FT DOMAIN 50..117
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT REPEAT 299..349
FT /note="Kelch 1"
FT REPEAT 350..399
FT /note="Kelch 2"
FT REPEAT 400..446
FT /note="Kelch 3"
FT REPEAT 448..493
FT /note="Kelch 4"
FT REPEAT 494..544
FT /note="Kelch 5"
FT REPEAT 545..593
FT /note="Kelch 6"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 641 AA; 72725 MW; 3C544A1DED2CA506 CRC64;
MAEDLETMKP SQAPQQPSLP QGSSKTYRSA EHSQALLSGL VALRDSGILF DVVLKVEGKS
IEAHRILLAA SCDYFRGMFA GGLKEMDQRE VQIHGVSYSA MCRIMDFIYT SDLALSVNNV
QETLTAACQL QISEVIQFCC DFLVSWVDEE NVLELYKLAD IFHLNRLTEQ LDTFVLKNFI
TFSQTQMYRQ LPLDKVFSLL NSNRLEVASE NEVYEGALLY HYTPEQLEKD QVSLLESPKL
LEAVRFPLMD LAILQRLHDK LGLCPLKTTV LKALEYHKNE SMQPVMQGPN TQLRSEFHCV
VGFGGMYSAP YTVLSDQVKY LNPLLGEWRP LTAPHAPRMS NQGIAVLNNF VYLIGGDNNV
RGYRAEARCW RYDPRHSRWF QIQSMQQPRA DLSVCVLGDF LYAVAGRDYH DELKEVERYD
PFTNTWEYVA PLQKQVHAHA AAALDGRMYV ACGRRGNTYL KDTFCYDPER DQWASVALSP
VRRAWHGMAA LQEKIYLIGG SNDDEGFRQD VLEVACYSPK TDQWTLVSPL PAGHGEPGIA
VLAKKIFVLG GRSHNQGDRT DYVHVYEAER DYWEDGPRLE DDISGMAACV LTLPRSVLMD
TDVWTQEMYM QYMDPVQNLA DNASEVMSVS DWEDLDNSGE D
