KLH23_HUMAN
ID KLH23_HUMAN Reviewed; 558 AA.
AC Q8NBE8; Q8N9B9; Q96FT8;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Kelch-like protein 23;
GN Name=KLHL23;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8NBE8; Q8IVD9: NUDCD3; NbExp=2; IntAct=EBI-2512246, EBI-744342;
CC Q8NBE8; P40337-2: VHL; NbExp=3; IntAct=EBI-2512246, EBI-12157263;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC04490.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK090653; BAC03497.1; -; mRNA.
DR EMBL; AK095131; BAC04490.1; ALT_INIT; mRNA.
DR EMBL; BC010437; AAH10437.2; -; mRNA.
DR CCDS; CCDS2236.1; -.
DR RefSeq; NP_001186219.1; NM_001199290.2.
DR RefSeq; NP_653312.2; NM_144711.5.
DR AlphaFoldDB; Q8NBE8; -.
DR SMR; Q8NBE8; -.
DR BioGRID; 127354; 33.
DR BioGRID; 1529322; 1.
DR IntAct; Q8NBE8; 26.
DR MINT; Q8NBE8; -.
DR STRING; 9606.ENSP00000376419; -.
DR iPTMnet; Q8NBE8; -.
DR PhosphoSitePlus; Q8NBE8; -.
DR SwissPalm; Q8NBE8; -.
DR BioMuta; KLHL23; -.
DR DMDM; 74751169; -.
DR MassIVE; Q8NBE8; -.
DR PaxDb; Q8NBE8; -.
DR PeptideAtlas; Q8NBE8; -.
DR PRIDE; Q8NBE8; -.
DR ProteomicsDB; 72759; -.
DR Antibodypedia; 33817; 81 antibodies from 17 providers.
DR DNASU; 151230; -.
DR Ensembl; ENST00000272797.8; ENSP00000272797.4; ENSG00000213160.10.
DR Ensembl; ENST00000392647.7; ENSP00000376419.2; ENSG00000213160.10.
DR GeneID; 100526832; -.
DR GeneID; 151230; -.
DR KEGG; hsa:100526832; -.
DR KEGG; hsa:151230; -.
DR MANE-Select; ENST00000392647.7; ENSP00000376419.2; NM_144711.6; NP_653312.2.
DR UCSC; uc002ufh.3; human.
DR CTD; 100526832; -.
DR CTD; 151230; -.
DR DisGeNET; 100526832; -.
DR DisGeNET; 151230; -.
DR GeneCards; KLHL23; -.
DR HGNC; HGNC:27506; KLHL23.
DR HPA; ENSG00000213160; Low tissue specificity.
DR neXtProt; NX_Q8NBE8; -.
DR OpenTargets; ENSG00000213160; -.
DR PharmGKB; PA142671575; -.
DR VEuPathDB; HostDB:ENSG00000213160; -.
DR eggNOG; KOG4441; Eukaryota.
DR GeneTree; ENSGT00940000159106; -.
DR HOGENOM; CLU_004253_14_6_1; -.
DR InParanoid; Q8NBE8; -.
DR OMA; HIWDPIS; -.
DR OrthoDB; 400213at2759; -.
DR PhylomeDB; Q8NBE8; -.
DR TreeFam; TF329218; -.
DR PathwayCommons; Q8NBE8; -.
DR SignaLink; Q8NBE8; -.
DR BioGRID-ORCS; 100526832; 4 hits in 141 CRISPR screens.
DR BioGRID-ORCS; 151230; 12 hits in 1100 CRISPR screens.
DR Pharos; Q8NBE8; Tdark.
DR PRO; PR:Q8NBE8; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q8NBE8; protein.
DR Bgee; ENSG00000213160; Expressed in cortical plate and 193 other tissues.
DR ExpressionAtlas; Q8NBE8; baseline and differential.
DR Genevisible; Q8NBE8; HS.
DR Gene3D; 2.120.10.80; -; 2.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 6.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF117281; SSF117281; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 1: Evidence at protein level;
KW Kelch repeat; Reference proteome; Repeat.
FT CHAIN 1..558
FT /note="Kelch-like protein 23"
FT /id="PRO_0000242157"
FT DOMAIN 36..104
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 139..240
FT /note="BACK"
FT REPEAT 274..320
FT /note="Kelch 1"
FT REPEAT 321..369
FT /note="Kelch 2"
FT REPEAT 370..416
FT /note="Kelch 3"
FT REPEAT 418..466
FT /note="Kelch 4"
FT REPEAT 467..508
FT /note="Kelch 5"
FT REPEAT 510..557
FT /note="Kelch 6"
SQ SEQUENCE 558 AA; 63923 MW; 17DB1B8AD964549B CRC64;
MALKGQEDYI YLFKDSTHPV DFLDAFRTFY LDGLFTDITL QCPSGIIFHC HRAVLAACSN
YFKAMFTADM KEKFKNKIKL SGIHHDILEG LVNYAYTSQI EITKRNVQSL LEAADLLQFL
SVKKACERFL VRHLDIDNCI GMHSFAEFHV CPELEKESRR ILCSKFKEVW QQEEFLEISL
EKFLFILSRK NLSVWKEEAI IEPVIKWTAH DVENRIECLY NLLSYINIDI DPVYLKTALG
LQRSCLLTEN KIRSLIYNAL NPMHKEISQR STATMYIIGG YYWHPLSEVH IWDPLTNVWI
QGAEIPDYTR ESYGVTCLGP NIYVTGGYRT DNIEALDTVW IYNSESDEWT EGLPMLNARY
YHCAVTLGGC VYALGGYRKG APAEEAEFYD PLKEKWIPIA NMIKGVGNAT ACVLHDVIYV
IGGHCGYRGS CTYDKVQSYN SDINEWSLIT SSPHPEYGLC SVPFENKLYL VGGQTTITEC
YDPEQNEWRE IAPMMERRME CGAVIMNGCI YVTGGYSYSK GTYLQSIEKY DPDLNKWEIV
GNLPSAMRSH GCVCVYNV
