KLH26_HUMAN
ID KLH26_HUMAN Reviewed; 615 AA.
AC Q53HC5; Q8TAP0; Q9NUX3;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Kelch-like protein 26;
GN Name=KLHL26;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cerebellum;
RA Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT MET-542.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
CC -!- INTERACTION:
CC Q53HC5; Q49AR9: ANKS1A; NbExp=3; IntAct=EBI-724915, EBI-11954519;
CC Q53HC5; P29972: AQP1; NbExp=3; IntAct=EBI-724915, EBI-745213;
CC Q53HC5; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-724915, EBI-744099;
CC Q53HC5; O75593: FOXH1; NbExp=3; IntAct=EBI-724915, EBI-1759806;
CC Q53HC5; Q0VD86: INCA1; NbExp=3; IntAct=EBI-724915, EBI-6509505;
CC Q53HC5; Q7L273: KCTD9; NbExp=3; IntAct=EBI-724915, EBI-4397613;
CC Q53HC5; Q9BRQ3: NUDT22; NbExp=3; IntAct=EBI-724915, EBI-10297093;
CC Q53HC5; P32242: OTX1; NbExp=3; IntAct=EBI-724915, EBI-740446;
CC Q53HC5; P78337: PITX1; NbExp=3; IntAct=EBI-724915, EBI-748265;
CC Q53HC5; Q7Z3K3: POGZ; NbExp=3; IntAct=EBI-724915, EBI-1389308;
CC Q53HC5; P0CG20: PRR35; NbExp=3; IntAct=EBI-724915, EBI-11986293;
CC Q53HC5; Q13148: TARDBP; NbExp=3; IntAct=EBI-724915, EBI-372899;
CC Q53HC5; Q15915: ZIC1; NbExp=3; IntAct=EBI-724915, EBI-11963196;
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DR EMBL; AK001940; BAA91990.1; -; mRNA.
DR EMBL; AK222656; BAD96376.1; -; mRNA.
DR EMBL; BC026319; AAH26319.1; -; mRNA.
DR CCDS; CCDS12384.1; -.
DR RefSeq; NP_060786.1; NM_018316.2.
DR AlphaFoldDB; Q53HC5; -.
DR SMR; Q53HC5; -.
DR BioGRID; 120582; 121.
DR IntAct; Q53HC5; 39.
DR MINT; Q53HC5; -.
DR STRING; 9606.ENSP00000300976; -.
DR iPTMnet; Q53HC5; -.
DR PhosphoSitePlus; Q53HC5; -.
DR BioMuta; KLHL26; -.
DR DMDM; 109892505; -.
DR EPD; Q53HC5; -.
DR jPOST; Q53HC5; -.
DR MassIVE; Q53HC5; -.
DR MaxQB; Q53HC5; -.
DR PaxDb; Q53HC5; -.
DR PeptideAtlas; Q53HC5; -.
DR PRIDE; Q53HC5; -.
DR ProteomicsDB; 62504; -.
DR Antibodypedia; 15139; 126 antibodies from 24 providers.
DR DNASU; 55295; -.
DR Ensembl; ENST00000300976.9; ENSP00000300976.3; ENSG00000167487.12.
DR GeneID; 55295; -.
DR KEGG; hsa:55295; -.
DR MANE-Select; ENST00000300976.9; ENSP00000300976.3; NM_018316.3; NP_060786.1.
DR UCSC; uc002njz.2; human.
DR CTD; 55295; -.
DR DisGeNET; 55295; -.
DR GeneCards; KLHL26; -.
DR HGNC; HGNC:25623; KLHL26.
DR HPA; ENSG00000167487; Low tissue specificity.
DR neXtProt; NX_Q53HC5; -.
DR OpenTargets; ENSG00000167487; -.
DR PharmGKB; PA143485524; -.
DR VEuPathDB; HostDB:ENSG00000167487; -.
DR eggNOG; KOG4441; Eukaryota.
DR GeneTree; ENSGT00940000159238; -.
DR HOGENOM; CLU_004253_14_3_1; -.
DR InParanoid; Q53HC5; -.
DR OMA; CPKDNEW; -.
DR OrthoDB; 250404at2759; -.
DR PhylomeDB; Q53HC5; -.
DR TreeFam; TF328485; -.
DR PathwayCommons; Q53HC5; -.
DR SignaLink; Q53HC5; -.
DR BioGRID-ORCS; 55295; 13 hits in 1112 CRISPR screens.
DR ChiTaRS; KLHL26; human.
DR GenomeRNAi; 55295; -.
DR Pharos; Q53HC5; Tdark.
DR PRO; PR:Q53HC5; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q53HC5; protein.
DR Bgee; ENSG00000167487; Expressed in secondary oocyte and 132 other tissues.
DR ExpressionAtlas; Q53HC5; baseline and differential.
DR Genevisible; Q53HC5; HS.
DR Gene3D; 2.120.10.80; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR030588; KLHL26.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR45632:SF13; PTHR45632:SF13; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 4.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF117281; SSF117281; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 1: Evidence at protein level;
KW Acetylation; Kelch repeat; Reference proteome; Repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:19413330"
FT CHAIN 2..615
FT /note="Kelch-like protein 26"
FT /id="PRO_0000242688"
FT DOMAIN 63..130
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 165..266
FT /note="BACK"
FT REPEAT 310..361
FT /note="Kelch 1"
FT REPEAT 362..413
FT /note="Kelch 2"
FT REPEAT 414..460
FT /note="Kelch 3"
FT REPEAT 461..508
FT /note="Kelch 4"
FT REPEAT 510..559
FT /note="Kelch 5"
FT REPEAT 561..608
FT /note="Kelch 6"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0007744|PubMed:19413330"
FT VARIANT 542
FT /note="V -> M (in dbSNP:rs17852384)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_026861"
FT CONFLICT 521
FT /note="D -> G (in Ref. 2; BAD96376)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 615 AA; 68139 MW; 1583474AF5A45E8D CRC64;
MAESGGSSGG AGGGGAFGAG PGPERPNSTA DKNGALKCTF SAPSHSTSLL QGLATLRAQG
QLLDVVLTIN REAFPAHKVV LAACSDYFRA MFTGGMREAS QDVIELKGVS ARGLRHIIDF
AYSAEVTLDL DCVQDVLGAA VFLQMLPVVE LCEEFLKAAM SVETCLNIGQ MATTFSLASL
RESVDAFTFR HFLQIAEEED FLRLPLERLV FFLQSNRLQS CAEIDLFRAA VRWLQHDPAR
RPRASHVLCH IRFPLMQSSE LVDSVQTLDI MVEDVLCRQY LLEAFNYQVL PFRQHEMQSP
RTAVRSDVPS LVTFGGTPYT DSDRSVSSKV YQLPEPGARH FRELTEMEVG CSHTCVAVLD
NFVYVAGGQH LQYRSGEGAV DACYRYDPHL NRWLRLQAMQ ESRIQFQLNV LCGMVYATGG
RNRAGSLASV ERYCPRRNEW GYACSLKRRT WGHAGAASGG RLYISGGYGI SVEDKKALHC
YDPVADQWEF KAPMSEPRVL HAMVGAGGRI YALGGRMDHV DRCFDVLAVE YYVPETDQWT
SVSPMRAGQS EAGCCLLERK IYIVGGYNWR LNNVTGIVQV YNTDTDEWER DLHFPESFAG
IACAPVLLPR AGTRR
