KLH26_MOUSE
ID KLH26_MOUSE Reviewed; 606 AA.
AC Q8BGY4; Q8CIG6; Q8R153;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Kelch-like protein 26;
GN Name=Klhl26;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Aorta, Cerebellum, Head, Hippocampus, and Vein;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC STRAIN=FVB/N; TISSUE=Mammary gland, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-430, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8BGY4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BGY4-2; Sequence=VSP_019474;
CC Name=3;
CC IsoId=Q8BGY4-3; Sequence=VSP_019473;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH23909.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK041089; BAC30815.1; -; mRNA.
DR EMBL; AK163170; BAE37219.1; -; mRNA.
DR EMBL; AK049946; BAC33999.1; -; mRNA.
DR EMBL; AK048601; BAC33385.1; -; mRNA.
DR EMBL; BC023909; AAH23909.1; ALT_INIT; mRNA.
DR EMBL; BC025484; AAH25484.1; -; mRNA.
DR EMBL; BC098185; AAH98185.1; -; mRNA.
DR CCDS; CCDS40373.1; -. [Q8BGY4-1]
DR CCDS; CCDS90410.1; -. [Q8BGY4-3]
DR RefSeq; NP_001116302.1; NM_001122830.1.
DR RefSeq; NP_848886.1; NM_178771.3. [Q8BGY4-1]
DR RefSeq; XP_006509717.1; XM_006509654.3. [Q8BGY4-3]
DR RefSeq; XP_011240600.1; XM_011242298.1.
DR AlphaFoldDB; Q8BGY4; -.
DR SMR; Q8BGY4; -.
DR STRING; 10090.ENSMUSP00000069077; -.
DR iPTMnet; Q8BGY4; -.
DR PhosphoSitePlus; Q8BGY4; -.
DR MaxQB; Q8BGY4; -.
DR PaxDb; Q8BGY4; -.
DR PRIDE; Q8BGY4; -.
DR ProteomicsDB; 263623; -. [Q8BGY4-1]
DR ProteomicsDB; 263624; -. [Q8BGY4-2]
DR ProteomicsDB; 263625; -. [Q8BGY4-3]
DR Antibodypedia; 15139; 126 antibodies from 24 providers.
DR Ensembl; ENSMUST00000066597; ENSMUSP00000069077; ENSMUSG00000055707. [Q8BGY4-1]
DR Ensembl; ENSMUST00000209567; ENSMUSP00000147349; ENSMUSG00000055707. [Q8BGY4-3]
DR Ensembl; ENSMUST00000210250; ENSMUSP00000147385; ENSMUSG00000055707. [Q8BGY4-2]
DR GeneID; 234378; -.
DR KEGG; mmu:234378; -.
DR UCSC; uc009mah.2; mouse. [Q8BGY4-1]
DR CTD; 55295; -.
DR MGI; MGI:2443079; Klhl26.
DR VEuPathDB; HostDB:ENSMUSG00000055707; -.
DR eggNOG; KOG4441; Eukaryota.
DR GeneTree; ENSGT00940000159238; -.
DR HOGENOM; CLU_004253_14_3_1; -.
DR InParanoid; Q8BGY4; -.
DR OMA; CPKDNEW; -.
DR OrthoDB; 250404at2759; -.
DR PhylomeDB; Q8BGY4; -.
DR TreeFam; TF328485; -.
DR BioGRID-ORCS; 234378; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Klhl26; mouse.
DR PRO; PR:Q8BGY4; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8BGY4; protein.
DR Bgee; ENSMUSG00000055707; Expressed in primary visual cortex and 220 other tissues.
DR ExpressionAtlas; Q8BGY4; baseline and differential.
DR Genevisible; Q8BGY4; MM.
DR Gene3D; 2.120.10.80; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR030588; KLHL26.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR45632:SF13; PTHR45632:SF13; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 3.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 5.
DR SUPFAM; SSF117281; SSF117281; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Kelch repeat; Phosphoprotein;
KW Reference proteome; Repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q53HC5"
FT CHAIN 2..606
FT /note="Kelch-like protein 26"
FT /id="PRO_0000242689"
FT DOMAIN 54..121
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 156..257
FT /note="BACK"
FT REPEAT 301..352
FT /note="Kelch 1"
FT REPEAT 353..404
FT /note="Kelch 2"
FT REPEAT 406..451
FT /note="Kelch 3"
FT REPEAT 452..499
FT /note="Kelch 4"
FT REPEAT 501..550
FT /note="Kelch 5"
FT REPEAT 552..599
FT /note="Kelch 6"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q53HC5"
FT MOD_RES 430
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 1..81
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_019473"
FT VAR_SEQ 80..113
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_019474"
SQ SEQUENCE 606 AA; 67031 MW; 626C8E3ED7452D59 CRC64;
MAESGGSSGS SQSPERPSSL ADRNGALKCT FSAAGHSTGL LQGLAALRAQ GQLLDVVLTV
NSEAFHAHKV VLAACSDYFR AMFTGGMREA NQAVIQLQGV SARGLRHIID FAYSAEVTLD
LDCVQDVLGA AVFLQMLPVV ELCEDFLKAA MSVETCLHIG QMATTFSLTS LRESVDAFTF
RHFLQIAAEE DFLRLPLERL VFFLQSNRLQ SCAEIDLFRA AVRWLQHDPA RRARASLVLR
HVRFPLMQPA ELVDSVQTLD VMLDDALCRQ YLLEAFSYHV LPCRQHDMQS PRTAVRSDVA
SLVAFGGTPY TDSDRAVSSK VFQLPEPGAR HFRELTEMEL GCSHAGVAVL DNFVYVAGGQ
HLQHRSGEGA VDACYRYDPQ RNRWLRLRAL RESRVQFQLT ALGGLLYATG GRNRAGSLAS
VERYCPRRDS WDFACPLKRR TWGHAGAAAA GRLYISGGYG VSAEDKKALQ CYDPAADRWE
PRAPMREPRV LHAMLGAAGR IYALGGRMDH VDRCFDVLAV EYYVPDADQW TSVTPMRAGQ
SEAGCCLLER KIYIVGGYNW RLNNVTGIVQ VYNTETDEWE RDLHFPESFA GIACAAVLLP
RSGHGR
