KLH28_HUMAN
ID KLH28_HUMAN Reviewed; 571 AA.
AC Q9NXS3; Q0VAL5;
DT 29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 29-MAR-2004, sequence version 2.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Kelch-like protein 28;
DE AltName: Full=BTB/POZ domain-containing protein 5;
GN Name=KLHL28; Synonyms=BTBD5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Colon;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9NXS3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NXS3-2; Sequence=VSP_009800;
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DR EMBL; AK000088; BAA90937.1; -; mRNA.
DR EMBL; BC121009; AAI21010.1; -; mRNA.
DR EMBL; BC121010; AAI21011.1; -; mRNA.
DR CCDS; CCDS9680.1; -. [Q9NXS3-1]
DR RefSeq; NP_060128.2; NM_017658.4. [Q9NXS3-1]
DR RefSeq; XP_005267827.1; XM_005267770.3. [Q9NXS3-1]
DR RefSeq; XP_011535149.1; XM_011536847.2. [Q9NXS3-1]
DR AlphaFoldDB; Q9NXS3; -.
DR SMR; Q9NXS3; -.
DR BioGRID; 120170; 26.
DR IntAct; Q9NXS3; 13.
DR STRING; 9606.ENSP00000379434; -.
DR iPTMnet; Q9NXS3; -.
DR PhosphoSitePlus; Q9NXS3; -.
DR BioMuta; KLHL28; -.
DR DMDM; 48474985; -.
DR EPD; Q9NXS3; -.
DR MassIVE; Q9NXS3; -.
DR PaxDb; Q9NXS3; -.
DR PeptideAtlas; Q9NXS3; -.
DR PRIDE; Q9NXS3; -.
DR ProteomicsDB; 83132; -. [Q9NXS3-1]
DR ProteomicsDB; 83133; -. [Q9NXS3-2]
DR Antibodypedia; 10174; 156 antibodies from 22 providers.
DR DNASU; 54813; -.
DR Ensembl; ENST00000396128.9; ENSP00000379434.4; ENSG00000179454.14. [Q9NXS3-1]
DR GeneID; 54813; -.
DR KEGG; hsa:54813; -.
DR MANE-Select; ENST00000396128.9; ENSP00000379434.4; NM_017658.5; NP_060128.2.
DR UCSC; uc001wvr.4; human. [Q9NXS3-1]
DR CTD; 54813; -.
DR DisGeNET; 54813; -.
DR GeneCards; KLHL28; -.
DR HGNC; HGNC:19741; KLHL28.
DR HPA; ENSG00000179454; Tissue enhanced (bone).
DR neXtProt; NX_Q9NXS3; -.
DR OpenTargets; ENSG00000179454; -.
DR PharmGKB; PA162393472; -.
DR VEuPathDB; HostDB:ENSG00000179454; -.
DR eggNOG; KOG4441; Eukaryota.
DR GeneTree; ENSGT00940000158586; -.
DR HOGENOM; CLU_004253_14_2_1; -.
DR InParanoid; Q9NXS3; -.
DR PhylomeDB; Q9NXS3; -.
DR TreeFam; TF329218; -.
DR PathwayCommons; Q9NXS3; -.
DR SignaLink; Q9NXS3; -.
DR BioGRID-ORCS; 54813; 9 hits in 1116 CRISPR screens.
DR ChiTaRS; KLHL28; human.
DR GenomeRNAi; 54813; -.
DR Pharos; Q9NXS3; Tdark.
DR PRO; PR:Q9NXS3; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q9NXS3; protein.
DR Bgee; ENSG00000179454; Expressed in secondary oocyte and 190 other tissues.
DR ExpressionAtlas; Q9NXS3; baseline and differential.
DR Genevisible; Q9NXS3; HS.
DR Gene3D; 2.120.10.80; -; 2.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 5.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF50965; SSF50965; 2.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Kelch repeat; Reference proteome; Repeat.
FT CHAIN 1..571
FT /note="Kelch-like protein 28"
FT /id="PRO_0000119064"
FT DOMAIN 35..102
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT REPEAT 284..331
FT /note="Kelch 1"
FT REPEAT 332..386
FT /note="Kelch 2"
FT REPEAT 387..433
FT /note="Kelch 3"
FT REPEAT 435..479
FT /note="Kelch 4"
FT REPEAT 480..526
FT /note="Kelch 5"
FT REPEAT 528..570
FT /note="Kelch 6"
FT VAR_SEQ 301..571
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_009800"
FT VARIANT 349
FT /note="I -> V (in dbSNP:rs35728857)"
FT /id="VAR_061339"
FT CONFLICT 10
FT /note="L -> P (in Ref. 1; BAA90937)"
FT /evidence="ECO:0000305"
FT CONFLICT 89
FT /note="I -> F (in Ref. 1; BAA90937)"
FT /evidence="ECO:0000305"
FT CONFLICT 300
FT /note="S -> R (in Ref. 1; BAA90937)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 571 AA; 64192 MW; 0E26AEABCAD51220 CRC64;
MDHTSPTYML ANLTHLHSEQ LLQGLNLLRQ HHELCDIILR VGDVKIHAHK VVLASVSPYF
KAMFTGNLSE KENSEVEFQC IDETALQAIV EYAYTGTVFI SQDTVESLLP AANLLQIKLV
LKECCAFLES QLDPGNCIGI SRFAETYGCR DLYLAATKYI CQNFEAVCQT EEFFELTHAD
LDEIVSNDCL NVATEETVFY ALESWIKYDV QERQKYLAQL LNSVRLPLLS VKFLTRLYEA
NHLIRDDRTC KHLLNEALKY HFMPEHRLSH QTVLMTRPRC APKVLCAVGG KSGLFACLDS
VEMYFPQNDS WIGLAPLNIP RYEFGICVLD QKVYVIGGIA TNVRPGVTIR KHENSVECWN
PDTNTWTSLE RMNESRSTLG VVVLAGELYA LGGYDGQSYL QSVEKYIPKI RKWQPVAPMT
TTRSCFAAAV LDGMIYAIGG YGPAHMNSVE RYDPSKDSWE MVASMADKRI HFGVGVMLGF
IFVVGGHNGV SHLSSIERYD PHQNQWTVCR PMKEPRTGVG AAVIDNYLYV VGGHSGSSYL
NTVQKYDPIS DTWLDSAGMI YCRCNFGLTA L
