KLH28_MOUSE
ID KLH28_MOUSE Reviewed; 571 AA.
AC Q9CR40; Q9CYV0;
DT 29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Kelch-like protein 28;
DE AltName: Full=BTB/POZ domain-containing protein 5;
GN Name=Klhl28; Synonyms=Btbd5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Embryo, Kidney, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9CR40-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9CR40-2; Sequence=VSP_009801;
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DR EMBL; AK002637; BAB22250.1; -; mRNA.
DR EMBL; AK012778; BAB28463.1; -; mRNA.
DR EMBL; AK013278; BAB28765.1; -; mRNA.
DR EMBL; AK014466; BAB29371.1; -; mRNA.
DR EMBL; AK016422; BAB30225.1; -; mRNA.
DR EMBL; BC037017; AAH37017.1; -; mRNA.
DR CCDS; CCDS25938.1; -. [Q9CR40-1]
DR RefSeq; NP_079983.1; NM_025707.3. [Q9CR40-1]
DR RefSeq; XP_006516219.1; XM_006516156.3. [Q9CR40-1]
DR AlphaFoldDB; Q9CR40; -.
DR SMR; Q9CR40; -.
DR BioGRID; 211647; 1.
DR STRING; 10090.ENSMUSP00000021331; -.
DR PhosphoSitePlus; Q9CR40; -.
DR EPD; Q9CR40; -.
DR PaxDb; Q9CR40; -.
DR PRIDE; Q9CR40; -.
DR ProteomicsDB; 265002; -. [Q9CR40-1]
DR ProteomicsDB; 265003; -. [Q9CR40-2]
DR Antibodypedia; 10174; 156 antibodies from 22 providers.
DR Ensembl; ENSMUST00000021331; ENSMUSP00000021331; ENSMUSG00000020948. [Q9CR40-1]
DR Ensembl; ENSMUST00000222508; ENSMUSP00000152602; ENSMUSG00000020948. [Q9CR40-1]
DR GeneID; 66689; -.
DR KEGG; mmu:66689; -.
DR UCSC; uc007nqp.1; mouse. [Q9CR40-1]
DR CTD; 54813; -.
DR MGI; MGI:1913939; Klhl28.
DR VEuPathDB; HostDB:ENSMUSG00000020948; -.
DR eggNOG; KOG4441; Eukaryota.
DR GeneTree; ENSGT00940000158586; -.
DR HOGENOM; CLU_004253_14_2_1; -.
DR InParanoid; Q9CR40; -.
DR OMA; ESSVECW; -.
DR OrthoDB; 709680at2759; -.
DR PhylomeDB; Q9CR40; -.
DR TreeFam; TF329218; -.
DR BioGRID-ORCS; 66689; 4 hits in 73 CRISPR screens.
DR PRO; PR:Q9CR40; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q9CR40; protein.
DR Bgee; ENSMUSG00000020948; Expressed in olfactory epithelium and 224 other tissues.
DR Genevisible; Q9CR40; MM.
DR Gene3D; 2.120.10.80; -; 2.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 5.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF50965; SSF50965; 2.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Kelch repeat; Reference proteome; Repeat.
FT CHAIN 1..571
FT /note="Kelch-like protein 28"
FT /id="PRO_0000119065"
FT DOMAIN 35..102
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT REPEAT 284..331
FT /note="Kelch 1"
FT REPEAT 332..386
FT /note="Kelch 2"
FT REPEAT 387..433
FT /note="Kelch 3"
FT REPEAT 435..479
FT /note="Kelch 4"
FT REPEAT 480..526
FT /note="Kelch 5"
FT REPEAT 528..570
FT /note="Kelch 6"
FT VAR_SEQ 250..571
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_009801"
SQ SEQUENCE 571 AA; 64125 MW; 2720D1481FAAB1F9 CRC64;
MDHTAPTYML ANLTHLHSEQ LLQGLNLLRQ HHELCDIILR VGDVKIHAHK VVLASISPYF
KAMFTGNLSE KENSEVEFQC IDEAALQAIV EYAYTGTVFI SQDTVESLLP AANLLQIKLV
LKECCAFLES QLDPGNCIGI SRFAETYGCH DLYLAATKFI CQNFESVCQT EEFFELTHAD
LDEIVSNDCL NVATEETVFY ALESWIKYDV QERQKYLAQL LNSVRLPLLS VKFLTRLYEA
NHLIRDDRTC KHLLNEALKY HFMPEHRLSH QTVLMTRPRC APKVLCAVGG KSGLFACLDS
VEMYFPQNDS WIGLAPLNIP RYEFGICVLD QKVFVIGGIE TSVRPGMTVR KHENSVECWN
PDTNTWTSLE RMNESRSTLG VAVLAGEVFA LGGYDGQSYL QSVEKYIPKI RQWQPVAPMT
TTRSCFAAAV LDGMLYAIGG YGPAHMNSVE RYDPSKDSWE MVAPMADKRI HFGVGVMLGF
IFVVGGHNGV SHLSSIERYD PHQNQWTVCR PMKEPRTGVG AAVIDNYLYV VGGHSGSSYL
NTVQKYDPIS DTWLDSAGMI YCRCNFGLTA L
