KLH29_MOUSE
ID KLH29_MOUSE Reviewed; 875 AA.
AC Q80T74; A6H646;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 14-MAY-2014, sequence version 3.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Kelch-like protein 29;
DE AltName: Full=Kelch repeat and BTB domain-containing protein 9;
GN Name=Klhl29; Synonyms=Kbtbd9, Kiaa1921;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- CAUTION: Although the complete sequence is not known with certainty,
CC sequence shown here appears to be the most probable in accordance with
CC human sequence ortholog. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI38284.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI45749.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC65854.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK122572; BAC65854.1; ALT_INIT; mRNA.
DR EMBL; BC138283; AAI38284.1; ALT_INIT; mRNA.
DR EMBL; BC145748; AAI45749.1; ALT_INIT; mRNA.
DR CCDS; CCDS49021.1; -.
DR RefSeq; NP_001157965.1; NM_001164493.1.
DR AlphaFoldDB; Q80T74; -.
DR SMR; Q80T74; -.
DR BioGRID; 228982; 9.
DR STRING; 10090.ENSMUSP00000020958; -.
DR iPTMnet; Q80T74; -.
DR PhosphoSitePlus; Q80T74; -.
DR MaxQB; Q80T74; -.
DR PaxDb; Q80T74; -.
DR PRIDE; Q80T74; -.
DR ProteomicsDB; 263626; -.
DR Antibodypedia; 27362; 89 antibodies from 24 providers.
DR Ensembl; ENSMUST00000020958; ENSMUSP00000020958; ENSMUSG00000020627.
DR GeneID; 208439; -.
DR KEGG; mmu:208439; -.
DR UCSC; uc007myw.3; mouse.
DR CTD; 114818; -.
DR MGI; MGI:2683857; Klhl29.
DR VEuPathDB; HostDB:ENSMUSG00000020627; -.
DR eggNOG; KOG4441; Eukaryota.
DR GeneTree; ENSGT00940000158824; -.
DR HOGENOM; CLU_004253_4_0_1; -.
DR InParanoid; Q80T74; -.
DR OMA; IPLMPGH; -.
DR OrthoDB; 156311at2759; -.
DR PhylomeDB; Q80T74; -.
DR BioGRID-ORCS; 208439; 4 hits in 72 CRISPR screens.
DR ChiTaRS; Klhl29; mouse.
DR PRO; PR:Q80T74; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q80T74; protein.
DR Bgee; ENSMUSG00000020627; Expressed in humerus cartilage element and 196 other tissues.
DR ExpressionAtlas; Q80T74; baseline and differential.
DR Genevisible; Q80T74; MM.
DR Gene3D; 2.120.10.80; -; 2.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 3.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF117281; SSF117281; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 2: Evidence at transcript level;
KW Kelch repeat; Reference proteome; Repeat.
FT CHAIN 1..875
FT /note="Kelch-like protein 29"
FT /id="PRO_0000119087"
FT DOMAIN 329..401
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT REPEAT 585..635
FT /note="Kelch 1"
FT REPEAT 637..683
FT /note="Kelch 2"
FT REPEAT 684..730
FT /note="Kelch 3"
FT REPEAT 732..778
FT /note="Kelch 4"
FT REPEAT 779..821
FT /note="Kelch 5"
FT REPEAT 822..870
FT /note="Kelch 6"
FT REGION 113..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 240..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..273
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 875 AA; 94359 MW; 3B5AB4A0A30D2968 CRC64;
MSRHHSRFER DYRIGWDRRE WSVNGTHGAT SVCSVTSGAG GSTASSLSAR PGLLPLPVVP
SRLPTPATAP APCTTGSSEA ITSLVVSSAS AATTKAPGIS KADNQSQGLT TSIRWGQTPV
NQSTPWDTDE PPSKQMRESD NPGTGPWVTT VAAGNQPSLI THSYGVTQPP TFSPAVNVQA
PVIGVTPSLP PHVGPQLPLI PGHYSLPQPP SQPLSSVVVN MPAQALYASP QPLAVSTLPG
VGQVSRPGPT PVGNGHMAGP LLPPPPPAQP SAALPSSVPA TNGPPTTDSA HGLQMLRTIG
VGKYEFTDPG HPKEMLKELN QQRRAKAFTD LKIVVEGREF EVHQNVLASC SLYFKDLIQR
SVQDSSQSSR EKLELVLSNL QADVLELLLE FVYTGSLVID SANAKTLLEA ASKFQFHTFC
KVCVSFLEKQ LTASNCLGVL AMAEAMQCSE LYHMAKAFAL QIFPEVAAQE EILSISKDDF
IAYVSNDSLN TKAEELVYET VIKWIKKDPA TRAQYAAELL AAVRLPFIHP SYLLNVVDNE
ELIKSSEACR DLVNEAKRYH MLPHARQEMQ TPRTRPRLSA GVAEVIVLVG GRQMVGMTQR
SLVAVTCWNP QNNKWYPLAS LPFYDREFFS VVSAGDNIYL SGGMESGVTL ADVWCYMSLL
DNWNLVSRMT VPRCRHNSLV YDGKIYTLGG LGVAGNVDHV ERYDTITNQW EAVAPLPKAV
HSAAATVCGG KIYVFGGVNE AGRAAGVLQS YVPQTNTWSF IESPMIDNKY APAVTLNGFV
FILGGAYARA TTIYDPEKGN IKAGPNMNHS RQFCSAVVLD GKIYATGGIV SSEGPALGNM
EAYEPTTNTW TLLPHMPCPV FRHGCVVIKK YIQSG
