KLH30_MOUSE
ID KLH30_MOUSE Reviewed; 581 AA.
AC Q8C3F7; Q9D692;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Kelch-like protein 30;
GN Name=Klhl30;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Heart, and Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB29415.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK014532; BAB29415.1; ALT_FRAME; mRNA.
DR EMBL; AK086025; BAC39595.1; -; mRNA.
DR EMBL; AK146580; BAE27276.1; -; mRNA.
DR EMBL; BC115428; AAI15429.1; -; mRNA.
DR EMBL; BC115429; AAI15430.1; -; mRNA.
DR CCDS; CCDS15161.1; -.
DR RefSeq; NP_081827.1; NM_027551.2.
DR AlphaFoldDB; Q8C3F7; -.
DR SMR; Q8C3F7; -.
DR STRING; 10090.ENSMUSP00000027533; -.
DR PhosphoSitePlus; Q8C3F7; -.
DR PaxDb; Q8C3F7; -.
DR PeptideAtlas; Q8C3F7; -.
DR PRIDE; Q8C3F7; -.
DR ProteomicsDB; 263627; -.
DR Antibodypedia; 50046; 80 antibodies from 14 providers.
DR DNASU; 70788; -.
DR Ensembl; ENSMUST00000027533; ENSMUSP00000027533; ENSMUSG00000026308.
DR GeneID; 70788; -.
DR KEGG; mmu:70788; -.
DR UCSC; uc007cai.1; mouse.
DR CTD; 377007; -.
DR MGI; MGI:1918038; Klhl30.
DR VEuPathDB; HostDB:ENSMUSG00000026308; -.
DR eggNOG; KOG4441; Eukaryota.
DR GeneTree; ENSGT00940000158597; -.
DR HOGENOM; CLU_004253_14_6_1; -.
DR InParanoid; Q8C3F7; -.
DR OMA; KAWAFLL; -.
DR OrthoDB; 743142at2759; -.
DR PhylomeDB; Q8C3F7; -.
DR TreeFam; TF329218; -.
DR BioGRID-ORCS; 70788; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q8C3F7; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q8C3F7; protein.
DR Bgee; ENSMUSG00000026308; Expressed in knee joint and 88 other tissues.
DR Genevisible; Q8C3F7; MM.
DR Gene3D; 2.120.10.80; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR030582; KLHL30.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR24412:SF398; PTHR24412:SF398; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 1.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 4.
DR SUPFAM; SSF117281; SSF117281; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 2: Evidence at transcript level;
KW Kelch repeat; Reference proteome; Repeat.
FT CHAIN 1..581
FT /note="Kelch-like protein 30"
FT /id="PRO_0000274595"
FT DOMAIN 33..100
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 135..237
FT /note="BACK"
FT REPEAT 280..327
FT /note="Kelch 1"
FT REPEAT 328..378
FT /note="Kelch 2"
FT REPEAT 379..423
FT /note="Kelch 3"
FT REPEAT 425..472
FT /note="Kelch 4"
FT REPEAT 474..514
FT /note="Kelch 5"
FT REPEAT 515..564
FT /note="Kelch 6"
SQ SEQUENCE 581 AA; 64605 MW; 6732EE9079B186E3 CRC64;
MVRNLDDLDF HLPSHAQDML EGLQRLRSLP KLADVTLLVG DQELPCHRSL LALNSPYFHA
MFAGDFTESF LARVELRDVE PAMVGQLVDF VYTGRLTITQ ANVEALTRSA SRLNFPTVQK
VCGRYLQQQL DATNCLGICE FGEQQGLLGV AAKAWAFLRE NFEAVAQEDE FLQLARDRLA
TCLASDLLQV QPEQSRLEAL LRWVRHDPQD RAAHLPELLS LVHLDAVPRP CVQQLLATEP
LIQESEACQE ALSQGHSEEL PGLPQKMQEV LVVVGGRALE EDEDGGEEPS HHTGNFAFYN
TKARQWMALP DFPDYHKWGF SLAALNSDVY VTGGSRGTKT DTWSTTQAWC FPLKEAIWKP
VAPMLKARTN HASTALNGEI YAIGGTALDA VEVERYDPYT DSWAPVGPAP KYVSNFSAAG
CQGRLYLVGS SACKYNMLAL QCYSPVTDAW SVIASPFLPK YLSSPRCAAL NGALYLIGDN
TKKVYVYDPG ANLWQKVQSQ HSLHENGALV PLGDLLYVTG GRWQGMDGDY HVEMEAYDTV
RDAWARHGSL PRLWLYHGAS TIFLDVSKWT QPFIPTAPQE H
