ID   KLH31_DANRE             Reviewed;         635 AA.
AC   Q6Q7X9;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Kelch-like protein 31;
DE   AltName: Full=Kelch repeat and BTB domain-containing protein 1;
DE   AltName: Full=Kelch-like protein Klhl;
GN   Name=klhl31; Synonyms=kbtbd1, klhl;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RX   PubMed=15302408; DOI=10.1016/j.gene.2004.05.016;
RA   Wu Y.L., Gong Z.;
RT   "A novel zebrafish kelchlike gene klhl and its human ortholog KLHL display
RT   conserved expression patterns in skeletal and cardiac muscles.";
RL   Gene 338:75-83(2004).
CC   -!- TISSUE SPECIFICITY: Strongly expressed in fast skeletal muscle, and
CC       weakly in heart. Not expressed in other tissues.
CC       {ECO:0000269|PubMed:15302408}.
CC   -!- DEVELOPMENTAL STAGE: Expressed from 10.5 hours post-fertilization
CC       (hpf). During embryogenesis, expression is restricted to developing
CC       somites and heart. {ECO:0000269|PubMed:15302408}.
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DR   EMBL; AY553639; AAS84610.1; -; mRNA.
DR   RefSeq; NP_001003727.1; NM_001003727.2.
DR   RefSeq; XP_005156548.1; XM_005156491.3.
DR   AlphaFoldDB; Q6Q7X9; -.
DR   SMR; Q6Q7X9; -.
DR   STRING; 7955.ENSDARP00000111671; -.
DR   PaxDb; Q6Q7X9; -.
DR   Ensembl; ENSDART00000102791; ENSDARP00000093566; ENSDARG00000039066.
DR   Ensembl; ENSDART00000129911; ENSDARP00000110003; ENSDARG00000039066.
DR   GeneID; 407079; -.
DR   KEGG; dre:407079; -.
DR   CTD; 401265; -.
DR   ZFIN; ZDB-GENE-030131-2052; klhl31.
DR   eggNOG; KOG4441; Eukaryota.
DR   GeneTree; ENSGT00940000158352; -.
DR   HOGENOM; CLU_004253_14_3_1; -.
DR   InParanoid; Q6Q7X9; -.
DR   OMA; MPNSVTR; -.
DR   OrthoDB; 250404at2759; -.
DR   PhylomeDB; Q6Q7X9; -.
DR   TreeFam; TF328485; -.
DR   PRO; PR:Q6Q7X9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 13.
DR   Bgee; ENSDARG00000039066; Expressed in muscle tissue and 12 other tissues.
DR   ExpressionAtlas; Q6Q7X9; baseline.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0001933; P:negative regulation of protein phosphorylation; IEA:InterPro.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011498; Kelch_2.
DR   InterPro; IPR030604; KLHL31.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR45632:SF17; PTHR45632:SF17; 1.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 3.
DR   Pfam; PF07646; Kelch_2; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 6.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Kelch repeat; Reference proteome; Repeat.
FT   CHAIN           1..635
FT                   /note="Kelch-like protein 31"
FT                   /id="PRO_0000271037"
FT   DOMAIN          74..138
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          173..274
FT                   /note="BACK"
FT   REPEAT          318..366
FT                   /note="Kelch 1"
FT   REPEAT          367..420
FT                   /note="Kelch 2"
FT   REPEAT          421..467
FT                   /note="Kelch 3"
FT   REPEAT          469..514
FT                   /note="Kelch 4"
FT   REPEAT          516..566
FT                   /note="Kelch 5"
FT   REPEAT          567..615
FT                   /note="Kelch 6"
SQ   SEQUENCE   635 AA;  70806 MW;  F949918CD09CE45A CRC64;
     MAPKKNKAAK KSKADINEMT IMVEDSPSNK INGLNTLLEG GNGFSCISTE VTDPVYAPNL
     LEGLGHMRQD SFLCDLTVAT KSKSFDVHKV VMASCSEYIQ NMLRKDPSLK KIELSDLSPV
     GLATVITYAY SGKLTLSLYT IGSTISAALL LQIHTLVKMC SDFLMRETSV ENCMYVVNIA
     DTYNLKETKE AAQKFMRENF IEFSEMEQFL KLTYEQINEF LTDDSLQLPS ELTAFQIAVK
     WLDFDEKRLK YAPDLLSNIR FGTITPQDLV SHVQNVPRMM QDAECHRLLV DAMNYHLLPF
     QQNILQSRRT KVRGGLRVLL TVGGRPALTE KSLSKDILYR DEDNVWNKLT EMPAKSFNQC
     VAVLDGFLYV AGGEDQNDAR NQAKHAVSNF SRYDPRFNTW IHLANMIQKR THFSLNTFNG
     LLFAVGGRNS DGCQASVECY VPSSNQWQMK APMEVPRCCH ASSVIDGKIL VSGGYINNAY
     SRAVCSYDPS TDSWQDKNSL SSPRGWHCSV TVGDRAYVLG GSQLGGRGER VDVLPVECYN
     PHSGQWSYVA PLLTGVSTAG AATLNNKIYL LGGWNEIEKK YKKCIQVYNP DLNEWTEDDE
     LPEATVGISC CVVTIPTRKT RESRASSVSS APVSI