KLH32_HUMAN
ID KLH32_HUMAN Reviewed; 620 AA.
AC Q96NJ5; B7Z346; B7Z4E2; E1P528; Q5THT0; Q96PY7;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Kelch-like protein 32;
DE AltName: Full=BTB and kelch domain-containing protein 5;
GN Name=KLHL32; Synonyms=BKLHD5, KIAA1900;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC TISSUE=Brain, and Hippocampus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 39-620 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=11572484; DOI=10.1093/dnares/8.4.179;
RA Nagase T., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XXI. The
RT complete sequences of 60 new cDNA clones from brain which code for large
RT proteins.";
RL DNA Res. 8:179-187(2001).
CC -!- INTERACTION:
CC Q96NJ5; Q9UMF0: ICAM5; NbExp=3; IntAct=EBI-6426390, EBI-6398041;
CC Q96NJ5; O14901: KLF11; NbExp=3; IntAct=EBI-6426390, EBI-948266;
CC Q96NJ5; P27361: MAPK3; NbExp=3; IntAct=EBI-6426390, EBI-73995;
CC Q96NJ5; Q13148: TARDBP; NbExp=3; IntAct=EBI-6426390, EBI-372899;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q96NJ5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96NJ5-2; Sequence=VSP_054888;
CC Name=3;
CC IsoId=Q96NJ5-3; Sequence=VSP_054888, VSP_054889;
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DR EMBL; AK055292; BAB70899.1; -; mRNA.
DR EMBL; AK295479; BAH12082.1; -; mRNA.
DR EMBL; AK297240; BAH12528.1; -; mRNA.
DR EMBL; AL033375; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL023656; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL356958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471051; EAW48499.1; -; Genomic_DNA.
DR EMBL; CH471051; EAW48500.1; -; Genomic_DNA.
DR EMBL; AB067487; BAB67793.1; -; mRNA.
DR CCDS; CCDS5038.1; -. [Q96NJ5-1]
DR CCDS; CCDS69154.1; -. [Q96NJ5-2]
DR CCDS; CCDS69155.1; -. [Q96NJ5-3]
DR RefSeq; NP_001273179.1; NM_001286250.1. [Q96NJ5-2]
DR RefSeq; NP_001273180.1; NM_001286251.1. [Q96NJ5-3]
DR RefSeq; NP_001273183.1; NM_001286254.2.
DR RefSeq; NP_001310181.1; NM_001323252.1. [Q96NJ5-1]
DR RefSeq; NP_001310182.1; NM_001323253.1.
DR RefSeq; NP_001310183.1; NM_001323254.1.
DR RefSeq; NP_001310184.1; NM_001323255.1.
DR RefSeq; NP_001310185.1; NM_001323256.1.
DR RefSeq; NP_001310186.1; NM_001323257.1.
DR RefSeq; NP_001310188.1; NM_001323259.1.
DR RefSeq; NP_001310189.1; NM_001323260.1.
DR RefSeq; NP_001310190.1; NM_001323261.1.
DR RefSeq; NP_001310191.1; NM_001323262.1.
DR RefSeq; NP_001310192.1; NM_001323263.1.
DR RefSeq; NP_001310193.1; NM_001323264.1.
DR RefSeq; NP_443136.2; NM_052904.3. [Q96NJ5-1]
DR AlphaFoldDB; Q96NJ5; -.
DR SMR; Q96NJ5; -.
DR BioGRID; 125354; 13.
DR IntAct; Q96NJ5; 6.
DR STRING; 9606.ENSP00000358265; -.
DR iPTMnet; Q96NJ5; -.
DR PhosphoSitePlus; Q96NJ5; -.
DR BioMuta; KLHL32; -.
DR DMDM; 116241269; -.
DR MassIVE; Q96NJ5; -.
DR MaxQB; Q96NJ5; -.
DR PaxDb; Q96NJ5; -.
DR PeptideAtlas; Q96NJ5; -.
DR PRIDE; Q96NJ5; -.
DR Antibodypedia; 31963; 86 antibodies from 22 providers.
DR DNASU; 114792; -.
DR Ensembl; ENST00000369261.9; ENSP00000358265.4; ENSG00000186231.17. [Q96NJ5-1]
DR Ensembl; ENST00000536676.5; ENSP00000440382.1; ENSG00000186231.17. [Q96NJ5-2]
DR Ensembl; ENST00000539200.5; ENSP00000441527.1; ENSG00000186231.17. [Q96NJ5-3]
DR GeneID; 114792; -.
DR KEGG; hsa:114792; -.
DR MANE-Select; ENST00000369261.9; ENSP00000358265.4; NM_052904.4; NP_443136.2.
DR UCSC; uc010kcm.2; human. [Q96NJ5-1]
DR CTD; 114792; -.
DR DisGeNET; 114792; -.
DR GeneCards; KLHL32; -.
DR HGNC; HGNC:21221; KLHL32.
DR HPA; ENSG00000186231; Tissue enriched (brain).
DR neXtProt; NX_Q96NJ5; -.
DR OpenTargets; ENSG00000186231; -.
DR PharmGKB; PA162393552; -.
DR VEuPathDB; HostDB:ENSG00000186231; -.
DR eggNOG; KOG1072; Eukaryota.
DR GeneTree; ENSGT00940000157179; -.
DR HOGENOM; CLU_004253_14_3_1; -.
DR InParanoid; Q96NJ5; -.
DR OMA; WSELTPM; -.
DR OrthoDB; 250404at2759; -.
DR PhylomeDB; Q96NJ5; -.
DR TreeFam; TF328485; -.
DR PathwayCommons; Q96NJ5; -.
DR SignaLink; Q96NJ5; -.
DR BioGRID-ORCS; 114792; 9 hits in 1103 CRISPR screens.
DR ChiTaRS; KLHL32; human.
DR GenomeRNAi; 114792; -.
DR Pharos; Q96NJ5; Tdark.
DR PRO; PR:Q96NJ5; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q96NJ5; protein.
DR Bgee; ENSG00000186231; Expressed in cortical plate and 117 other tissues.
DR ExpressionAtlas; Q96NJ5; baseline and differential.
DR Genevisible; Q96NJ5; HS.
DR Gene3D; 2.120.10.80; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR030570; KLHL32.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR45632:SF16; PTHR45632:SF16; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 3.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 5.
DR SUPFAM; SSF117281; SSF117281; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Kelch repeat; Reference proteome; Repeat.
FT CHAIN 1..620
FT /note="Kelch-like protein 32"
FT /id="PRO_0000119083"
FT DOMAIN 42..109
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT REPEAT 290..346
FT /note="Kelch 1"
FT REPEAT 347..398
FT /note="Kelch 2"
FT REPEAT 399..446
FT /note="Kelch 3"
FT REPEAT 447..494
FT /note="Kelch 4"
FT REPEAT 496..547
FT /note="Kelch 5"
FT REPEAT 549..599
FT /note="Kelch 6"
FT VAR_SEQ 69..104
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_054888"
FT VAR_SEQ 105..137
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_054889"
FT VARIANT 5
FT /note="R -> C (in dbSNP:rs35143662)"
FT /id="VAR_050053"
FT VARIANT 129
FT /note="N -> S (in dbSNP:rs2294763)"
FT /id="VAR_028279"
FT VARIANT 146
FT /note="D -> G (in dbSNP:rs12662753)"
FT /id="VAR_028280"
FT CONFLICT 331
FT /note="P -> S (in Ref. 1; BAB70899)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 620 AA; 70362 MW; AABDC5F667854931 CRC64;
MPSERCLSIQ EMLTGQRLCH SESHNDSVLA ALNQQRSDGI LCDITLIAEE QKFHAHKAVL
AACSDYFRAM FSLCMVESGA DEVNLHGVTS LGLKQALEFA YTGQILLEPG VIQDVLAAGS
HLQLLELLNL CSHYLIQELN SFNYLDLYRL ADLFNLTLLE KAVIDFLVKH LSELLKSRPE
EVLTLPYCLL QEVLKSDRLT SLSEEQIWQL AVRWLEHNCH YQYMDELLQY IRFGLMDVDT
LHTVALSHPL VQASETATAL VNEALEYHQS IYAQPVWQTR RTKPRFQSDT LYIIGGKKRE
VCKVKELRYF NPVDQENALI AAIANWSELA PMPVGRSHHC VAVMGDFLFV AGGEVEHASG
RTCAVRTACR YDPRSNSWAE IAPMKNCREH FVLGAMEEYL YAVGGRNELR QVLPTVERYC
PKKNKWTFVQ SFDRSLSCHA GYVADGLLWI SGGVTNTAQY QNRLMVYEPN QNKWISRSPM
LQRRVYHSMA AVQRKLYVLG GNDLDYNNDR ILVRHIDSYN IDTDQWTRCN FNLLTGQNES
GVAVHNGRIY LVGGYSIWTN EPLACIQVLD VSREGKEEVF YGPTLPFASN GIAACFLPAP
YFTCPNLQTL QVPHHRIGTI
