KLH33_HUMAN
ID KLH33_HUMAN Reviewed; 533 AA.
AC A6NCF5;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Kelch-like protein 33;
GN Name=KLHL33;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
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DR EMBL; AL355075; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS53882.1; -.
DR RefSeq; NP_001103467.2; NM_001109997.2.
DR AlphaFoldDB; A6NCF5; -.
DR SMR; A6NCF5; -.
DR BioGRID; 125816; 28.
DR IntAct; A6NCF5; 13.
DR STRING; 9606.ENSP00000341549; -.
DR iPTMnet; A6NCF5; -.
DR PhosphoSitePlus; A6NCF5; -.
DR BioMuta; KLHL33; -.
DR MassIVE; A6NCF5; -.
DR PaxDb; A6NCF5; -.
DR PeptideAtlas; A6NCF5; -.
DR PRIDE; A6NCF5; -.
DR Antibodypedia; 70728; 30 antibodies from 10 providers.
DR DNASU; 123103; -.
DR Ensembl; ENST00000344581.4; ENSP00000341549.4; ENSG00000185271.9.
DR GeneID; 123103; -.
DR KEGG; hsa:123103; -.
DR UCSC; uc010tli.2; human.
DR CTD; 123103; -.
DR DisGeNET; 123103; -.
DR GeneCards; KLHL33; -.
DR HGNC; HGNC:31952; KLHL33.
DR HPA; ENSG00000185271; Group enriched (skeletal muscle, tongue).
DR neXtProt; NX_A6NCF5; -.
DR PharmGKB; PA162393579; -.
DR VEuPathDB; HostDB:ENSG00000185271; -.
DR eggNOG; KOG1072; Eukaryota.
DR GeneTree; ENSGT00940000156265; -.
DR HOGENOM; CLU_004253_14_2_1; -.
DR InParanoid; A6NCF5; -.
DR OMA; QKVWWAR; -.
DR PhylomeDB; A6NCF5; -.
DR TreeFam; TF328485; -.
DR PathwayCommons; A6NCF5; -.
DR SignaLink; A6NCF5; -.
DR BioGRID-ORCS; 123103; 9 hits in 1103 CRISPR screens.
DR ChiTaRS; KLHL33; human.
DR GenomeRNAi; 123103; -.
DR Pharos; A6NCF5; Tdark.
DR PRO; PR:A6NCF5; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; A6NCF5; protein.
DR Bgee; ENSG00000185271; Expressed in skeletal muscle tissue and 88 other tissues.
DR ExpressionAtlas; A6NCF5; baseline and differential.
DR Gene3D; 2.120.10.80; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR030609; KLHL33.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR45632:SF14; PTHR45632:SF14; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF01344; Kelch_1; 4.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00612; Kelch; 5.
DR SUPFAM; SSF117281; SSF117281; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
PE 4: Predicted;
KW Kelch repeat; Reference proteome; Repeat.
FT CHAIN 1..533
FT /note="Kelch-like protein 33"
FT /id="PRO_0000324769"
FT REPEAT 210..258
FT /note="Kelch 1"
FT REPEAT 273..322
FT /note="Kelch 2"
FT REPEAT 323..369
FT /note="Kelch 3"
FT REPEAT 371..418
FT /note="Kelch 4"
FT REPEAT 419..465
FT /note="Kelch 5"
FT REPEAT 467..514
FT /note="Kelch 6"
FT VARIANT 163
FT /note="R -> H (in dbSNP:rs12587478)"
FT /id="VAR_039878"
FT VARIANT 176
FT /note="R -> Q (in dbSNP:rs17242648)"
FT /id="VAR_039879"
FT VARIANT 345
FT /note="E -> G (in dbSNP:rs1953225)"
FT /id="VAR_039880"
FT VARIANT 516
FT /note="A -> T (in dbSNP:rs7145318)"
FT /id="VAR_039881"
SQ SEQUENCE 533 AA; 57810 MW; 4B3DC69910F83FBF CRC64;
MLLSGMRESQ GTEVSLRTIS TQDLRLLVSF AYSGVVRARW PGLLRAAQAA LQYQSSSCLD
LCQKGLARGL SPARCLALFP MAEAPGLERL WSKARHYLLT HLPAVALCPA FPSLPAACLA
ELLDSDELHV QEEFEAFVAA RCWLAANPET QESEAKALLR CVRFGRMSTR ELRRVRAAGL
LPPLTPDLLH QLMVEADVPG QERRREPDRA LVVIGGDGLR PDMALRQPSR AVWWARAFRC
GVGLVRTVEW GQLPALPAPG RFRHGAASLA GSELYVCGGQ DFYSHSNTLA STLRWEPSQE
DWEEMAPLSQ ARSLFSLVAL DGKLYALGGR HNDVALDSVE TYNPELNVWR PAPALPAPCF
AHAAAILEGQ LYVSGGCGGT GQYLASLMHY DPKLEKPGTF LSPMGVPRAG HVMAALGGRL
YVAGGLGETE DLLSFEAYEL RTDSWTHLAP LPSPHVGAAS AVLQGELLVL GGYSHRTYAL
SHLIHAYCPG LGRWLCLGTL PRPRAEMPAC ILTLPAVQHI ALVPTPHQTK PAG
