KLH34_HUMAN
ID KLH34_HUMAN Reviewed; 644 AA.
AC Q8N239;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Kelch-like protein 34;
GN Name=KLHL34;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AK092279; BAC03848.1; -; mRNA.
DR EMBL; AL772392; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC109031; AAI09032.1; -; mRNA.
DR CCDS; CCDS14199.1; -.
DR RefSeq; NP_695002.1; NM_153270.2.
DR AlphaFoldDB; Q8N239; -.
DR SMR; Q8N239; -.
DR BioGRID; 129210; 71.
DR IntAct; Q8N239; 11.
DR STRING; 9606.ENSP00000368813; -.
DR iPTMnet; Q8N239; -.
DR PhosphoSitePlus; Q8N239; -.
DR BioMuta; KLHL34; -.
DR DMDM; 74750913; -.
DR MassIVE; Q8N239; -.
DR PaxDb; Q8N239; -.
DR PeptideAtlas; Q8N239; -.
DR PRIDE; Q8N239; -.
DR ProteomicsDB; 71653; -.
DR Antibodypedia; 55233; 39 antibodies from 13 providers.
DR DNASU; 257240; -.
DR Ensembl; ENST00000379499.3; ENSP00000368813.2; ENSG00000185915.5.
DR GeneID; 257240; -.
DR KEGG; hsa:257240; -.
DR MANE-Select; ENST00000379499.3; ENSP00000368813.2; NM_153270.3; NP_695002.1.
DR UCSC; uc004czz.2; human.
DR CTD; 257240; -.
DR DisGeNET; 257240; -.
DR GeneCards; KLHL34; -.
DR HGNC; HGNC:26634; KLHL34.
DR HPA; ENSG00000185915; Tissue enriched (skeletal).
DR neXtProt; NX_Q8N239; -.
DR OpenTargets; ENSG00000185915; -.
DR PharmGKB; PA162393594; -.
DR VEuPathDB; HostDB:ENSG00000185915; -.
DR eggNOG; KOG4441; Eukaryota.
DR GeneTree; ENSGT00940000162424; -.
DR HOGENOM; CLU_004253_14_3_1; -.
DR InParanoid; Q8N239; -.
DR OMA; RNVVGYD; -.
DR OrthoDB; 332430at2759; -.
DR PhylomeDB; Q8N239; -.
DR TreeFam; TF328485; -.
DR PathwayCommons; Q8N239; -.
DR SignaLink; Q8N239; -.
DR BioGRID-ORCS; 257240; 10 hits in 736 CRISPR screens.
DR GenomeRNAi; 257240; -.
DR Pharos; Q8N239; Tdark.
DR PRO; PR:Q8N239; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q8N239; protein.
DR Bgee; ENSG00000185915; Expressed in skeletal muscle tissue of rectus abdominis and 75 other tissues.
DR Genevisible; Q8N239; HS.
DR GO; GO:0005615; C:extracellular space; HDA:UniProtKB.
DR Gene3D; 2.120.10.80; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 4.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 5.
DR SUPFAM; SSF117281; SSF117281; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 2: Evidence at transcript level;
KW Kelch repeat; Reference proteome; Repeat.
FT CHAIN 1..644
FT /note="Kelch-like protein 34"
FT /id="PRO_0000274597"
FT DOMAIN 29..96
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 131..238
FT /note="BACK"
FT REPEAT 320..366
FT /note="Kelch 1"
FT REPEAT 367..425
FT /note="Kelch 2"
FT REPEAT 426..473
FT /note="Kelch 3"
FT REPEAT 475..526
FT /note="Kelch 4"
FT REPEAT 528..571
FT /note="Kelch 5"
FT REPEAT 573..623
FT /note="Kelch 6"
FT REGION 304..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..329
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 644 AA; 70612 MW; FB18DBF7CB20D3B8 CRC64;
MSYFLSYCKA HGGALLTGYQ ALRAEGFLCD VTLETEGSEF PAHRSLLACS SDYFRALFKS
HTQESRARVI HLHVPSAAGL QRLLDFIYTA WLSLSMDTVE DTLEAASYLQ VTEALGLCGR
YLERQLAPEN CCFAANVAAR FGLAHTLDAA ERCIVSHLQE LLARGAGPAG LLELNPTSLR
AVLGAPDVAR VPEARLLGLA LAWLRQEPTT ERLAHCTELL ERVRFGLVPA DVLRRVYSGS
GLVLPARVKG LIIQALNYHT TPSRQPLMQG EQTSIRSPQT RILLVGGRRA REVVIEEVAA
PQRAARGQVA APEPEEEEEE LEEEEEEEEW ELTQNVVAFD VYNHRWRSLT QLPTPLLGHS
VCTAGNFLFV LGGESPSGSA SSPLADDSRV VTAQVHRYDP RFHAWTEVPA MREARAHFWC
GAVGERLLAV GGLGAGGEVL ASVEMYDLRR DRWTAAGALP RALHGHAGAV GDRGVVYISG
GKAGRGEGGA SSLRDLYVLG PEEQVWSKKA PMGTARFGHH MAVLRGAVFA FLGRYEPFSE
IERYDPGADQ WTRLRPLPYD RFCYGLAVVE ETALLLGGLK WRDSRQVPTR NVVGYDLDLD
RWEDIGCALP WAWSGLRCAV LQLAEGGDDE REGEVGEALD LVLG
