KLH35_HUMAN
ID KLH35_HUMAN Reviewed; 583 AA.
AC Q6PF15; A2RU06; F5H412; Q86XM7; Q8NBB1;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-SEP-2014, sequence version 3.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Kelch-like protein 35;
GN Name=KLHL35;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 148-583 (ISOFORM 1).
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 190-583 (ISOFORM 2).
RC TISSUE=Substantia nigra;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- INTERACTION:
CC Q6PF15; P13196: ALAS1; NbExp=4; IntAct=EBI-9477654, EBI-3905054;
CC Q6PF15; Q92624: APPBP2; NbExp=6; IntAct=EBI-9477654, EBI-743771;
CC Q6PF15; Q13137: CALCOCO2; NbExp=3; IntAct=EBI-9477654, EBI-739580;
CC Q6PF15; B3EWG5: FAM25C; NbExp=3; IntAct=EBI-9477654, EBI-14240149;
CC Q6PF15; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-9477654, EBI-5916454;
CC Q6PF15; O43639: NCK2; NbExp=3; IntAct=EBI-9477654, EBI-713635;
CC Q6PF15; Q8WUN7: UBTD2; NbExp=3; IntAct=EBI-9477654, EBI-12867288;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6PF15-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6PF15-2; Sequence=VSP_034783, VSP_034784, VSP_034785;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH42952.3; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH57763.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI32709.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI32711.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC03585.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=EAW74965.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EAW74966.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AP000744; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471076; EAW74965.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CH471076; EAW74966.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC042952; AAH42952.3; ALT_INIT; mRNA.
DR EMBL; BC057763; AAH57763.1; ALT_INIT; mRNA.
DR EMBL; BC132708; AAI32709.1; ALT_INIT; mRNA.
DR EMBL; BC132710; AAI32711.1; ALT_INIT; mRNA.
DR EMBL; AK091109; BAC03585.1; ALT_INIT; mRNA.
DR CCDS; CCDS44685.2; -. [Q6PF15-1]
DR RefSeq; NP_001034637.2; NM_001039548.2. [Q6PF15-1]
DR AlphaFoldDB; Q6PF15; -.
DR SMR; Q6PF15; -.
DR BioGRID; 129497; 11.
DR IntAct; Q6PF15; 8.
DR STRING; 9606.ENSP00000438526; -.
DR iPTMnet; Q6PF15; -.
DR PhosphoSitePlus; Q6PF15; -.
DR BioMuta; KLHL35; -.
DR DMDM; 205831238; -.
DR MassIVE; Q6PF15; -.
DR MaxQB; Q6PF15; -.
DR PaxDb; Q6PF15; -.
DR PeptideAtlas; Q6PF15; -.
DR PRIDE; Q6PF15; -.
DR ProteomicsDB; 26436; -.
DR ProteomicsDB; 67101; -. [Q6PF15-1]
DR ProteomicsDB; 67102; -. [Q6PF15-2]
DR Antibodypedia; 45083; 113 antibodies from 20 providers.
DR DNASU; 283212; -.
DR Ensembl; ENST00000539798.3; ENSP00000438526.1; ENSG00000149243.17. [Q6PF15-1]
DR GeneID; 283212; -.
DR KEGG; hsa:283212; -.
DR MANE-Select; ENST00000539798.3; ENSP00000438526.1; NM_001039548.3; NP_001034637.2.
DR UCSC; uc001owm.3; human. [Q6PF15-1]
DR CTD; 283212; -.
DR DisGeNET; 283212; -.
DR GeneCards; KLHL35; -.
DR HGNC; HGNC:26597; KLHL35.
DR HPA; ENSG00000149243; Group enriched (brain, testis).
DR neXtProt; NX_Q6PF15; -.
DR OpenTargets; ENSG00000149243; -.
DR PharmGKB; PA162393595; -.
DR VEuPathDB; HostDB:ENSG00000149243; -.
DR eggNOG; KOG4441; Eukaryota.
DR GeneTree; ENSGT00940000161093; -.
DR InParanoid; Q6PF15; -.
DR OMA; GCEAPCA; -.
DR OrthoDB; 602930at2759; -.
DR PhylomeDB; Q6PF15; -.
DR TreeFam; TF351654; -.
DR PathwayCommons; Q6PF15; -.
DR SignaLink; Q6PF15; -.
DR BioGRID-ORCS; 283212; 19 hits in 1071 CRISPR screens.
DR GenomeRNAi; 283212; -.
DR Pharos; Q6PF15; Tdark.
DR PRO; PR:Q6PF15; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q6PF15; protein.
DR Bgee; ENSG00000149243; Expressed in ganglionic eminence and 115 other tissues.
DR ExpressionAtlas; Q6PF15; baseline and differential.
DR Genevisible; Q6PF15; HS.
DR Gene3D; 2.120.10.80; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR030601; KLHL35.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR24412:SF187; PTHR24412:SF187; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 4.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF117281; SSF117281; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Kelch repeat; Reference proteome; Repeat.
FT CHAIN 1..583
FT /note="Kelch-like protein 35"
FT /id="PRO_0000344466"
FT DOMAIN 41..119
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 146..248
FT /note="BACK"
FT REPEAT 301..350
FT /note="Kelch 1"
FT REPEAT 352..394
FT /note="Kelch 2"
FT REPEAT 395..441
FT /note="Kelch 3"
FT REPEAT 443..489
FT /note="Kelch 4"
FT REPEAT 490..531
FT /note="Kelch 5"
FT REPEAT 533..579
FT /note="Kelch 6"
FT VAR_SEQ 293
FT /note="R -> RRHWAYPHA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_034783"
FT VAR_SEQ 396..419
FT /note="LFAVGGFDGLRRLHSVERYDPFSN -> VGTSCSGCPGTQGTDLWMCWREVL
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_034784"
FT VAR_SEQ 420..583
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_034785"
SQ SEQUENCE 583 AA; 62892 MW; 05BA7D11DF77FD30 CRC64;
MRQGHAPEES EPGCEAPCAG PCHAQRVLQA LNAYRRSGTL TDVVLRAGGR DFPCHRAALS
AGSAYFRSLF AAGRPERGPA VVPVVPVAPE APGTSPAGAA AALAVVLDYV YGAGVRLRAE
DEAAAVLALA ERLGVAGLRE ACVRFLEGRL RAANSLALRR VAAAFSLAPL AERCGRVLRQ
AFAEVARHAD FLELAPDEVV ALLADPALGV AREEAVFEAA MRWVRHDAPA RRGQLRRLLE
HVRLPLLAPA YFLEKVEADE LLQACGECRP LLLEARACFI LGREAGALRT RPRRFMDLAE
VIVVIGGCDR KGLLKLPFAD AYHPESQRWT PLPSLPGYTR SEFAACALRN DVYVSGGHIN
SHDVWMFSSH LHTWIKVASL HKGRWRHKMA VVQGQLFAVG GFDGLRRLHS VERYDPFSNT
WAAAAPLPEA VSSAAVASCA GKLFVIGGAR QGGVNTDKVQ CFDPKEDRWS LRSPAPFSQR
CLEAVSLEDT IYVMGGLMSK IFTYDPGTDV WGEAAVLPSP VESCGVTVCD GKVHILGGRD
DRGESTDKVF TFDPSSGQVE VQPSLQRCTS SHGCVTIIQS LGR
