KLH35_MOUSE
ID KLH35_MOUSE Reviewed; 574 AA.
AC Q9CZ49; E9QMG1;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Kelch-like protein 35;
GN Name=Klhl35;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
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DR EMBL; AK013012; BAB28596.1; -; mRNA.
DR EMBL; AC115858; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS52320.1; -.
DR RefSeq; NP_082421.1; NM_028145.1.
DR AlphaFoldDB; Q9CZ49; -.
DR SMR; Q9CZ49; -.
DR STRING; 10090.ENSMUSP00000041363; -.
DR PhosphoSitePlus; Q9CZ49; -.
DR MaxQB; Q9CZ49; -.
DR PaxDb; Q9CZ49; -.
DR PRIDE; Q9CZ49; -.
DR ProteomicsDB; 265004; -.
DR Antibodypedia; 45083; 113 antibodies from 20 providers.
DR Ensembl; ENSMUST00000037359; ENSMUSP00000041363; ENSMUSG00000035298.
DR GeneID; 72184; -.
DR KEGG; mmu:72184; -.
DR UCSC; uc009ilq.2; mouse.
DR CTD; 283212; -.
DR MGI; MGI:1919434; Klhl35.
DR VEuPathDB; HostDB:ENSMUSG00000035298; -.
DR eggNOG; KOG4441; Eukaryota.
DR GeneTree; ENSGT00940000161093; -.
DR HOGENOM; CLU_004253_14_6_1; -.
DR InParanoid; Q9CZ49; -.
DR OMA; GCEAPCA; -.
DR OrthoDB; 602930at2759; -.
DR PhylomeDB; Q9CZ49; -.
DR TreeFam; TF351654; -.
DR BioGRID-ORCS; 72184; 3 hits in 74 CRISPR screens.
DR PRO; PR:Q9CZ49; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9CZ49; protein.
DR Bgee; ENSMUSG00000035298; Expressed in spermatocyte and 39 other tissues.
DR ExpressionAtlas; Q9CZ49; baseline and differential.
DR Genevisible; Q9CZ49; MM.
DR Gene3D; 2.120.10.80; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR030601; KLHL35.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR24412:SF187; PTHR24412:SF187; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 4.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF117281; SSF117281; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 2: Evidence at transcript level;
KW Kelch repeat; Reference proteome; Repeat.
FT CHAIN 1..574
FT /note="Kelch-like protein 35"
FT /id="PRO_0000344467"
FT DOMAIN 40..110
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 146..248
FT /note="BACK"
FT REPEAT 292..341
FT /note="Kelch 1"
FT REPEAT 343..385
FT /note="Kelch 2"
FT REPEAT 386..432
FT /note="Kelch 3"
FT REPEAT 434..480
FT /note="Kelch 4"
FT REPEAT 481..522
FT /note="Kelch 5"
FT REPEAT 524..570
FT /note="Kelch 6"
FT CONFLICT 168
FT /note="V -> L (in Ref. 1; BAB28596)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 574 AA; 62372 MW; FD8208E6D9CB4D3A CRC64;
MRETPEREEE PGTEAPCAAS CHAQRILQTL NAYRRSGTLT DVVLRAGGRD FPCHRAALSA
ASAHFRGLFA AGRPERAAAV VPVGPETPGT AAALAVVLDY VYGAGVRLRA EDEAAAVLAL
AERLGVAGLR EACARFLEGR LRAANSLALR RVAAAFSLAS LAERCGRVLR QAFVEVTRHA
DFLELAPDEV AALLADPALR VAREEAVFEA AMRWVRHDAP ARRGQLRRLL EHVRLPLLAP
AYFLEKVEAD ELLQACGDCR PLLLEARACF ILGREAGALR ARPRRFMDLA EVIVVIGGCD
RKGLLKLPFA DAYHPESQRW TPLPSLPGYT RSEFASCALR NDIYVSGGHI NSRDVWMFSS
HLNTWIKVAS MHKGRWRHKM VALQGQLFAV GGFDGLRRLR SVERYDPFSN TWAAIAPLPE
AVSSAAVAPC AGQLYVIGGA GQDGVNTDKV QCFDPKEDQW SLRSPAPFLQ RCLEAVSLED
TIYVVGGLMS KIFTYDPGSD VWREAADLPS PVESCGVTVC DGKVHILGGR DEHGESTSSV
FTFDPGTGQV EAQPSLQRCT SSHGCVTIVQ SLSR
