ID   KLH36_BOVIN             Reviewed;         616 AA.
AC   Q3B7M1;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Kelch-like protein 36;
GN   Name=KLHL36;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable substrate-specific adapter of an E3 ubiquitin-
CC       protein ligase complex which mediates the ubiquitination and subsequent
CC       proteasomal degradation of target proteins. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Interacts with CUL3. {ECO:0000250}.
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DR   EMBL; BC107546; AAI07547.1; -; mRNA.
DR   RefSeq; NP_001070586.1; NM_001077118.1.
DR   AlphaFoldDB; Q3B7M1; -.
DR   SMR; Q3B7M1; -.
DR   STRING; 9913.ENSBTAP00000011036; -.
DR   PaxDb; Q3B7M1; -.
DR   PRIDE; Q3B7M1; -.
DR   Ensembl; ENSBTAT00000011036; ENSBTAP00000011036; ENSBTAG00000008385.
DR   GeneID; 768061; -.
DR   KEGG; bta:768061; -.
DR   CTD; 79786; -.
DR   VEuPathDB; HostDB:ENSBTAG00000008385; -.
DR   VGNC; VGNC:30662; KLHL36.
DR   eggNOG; KOG4441; Eukaryota.
DR   GeneTree; ENSGT00940000157543; -.
DR   HOGENOM; CLU_004253_14_3_1; -.
DR   InParanoid; Q3B7M1; -.
DR   OMA; QYPEREN; -.
DR   OrthoDB; 250404at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000008385; Expressed in oocyte and 105 other tissues.
DR   GO; GO:0097602; F:cullin family protein binding; IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR017096; BTB-kelch_protein.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR030585; KLHL36.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR45632:SF4; PTHR45632:SF4; 1.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 4.
DR   PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 6.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Kelch repeat; Reference proteome; Repeat; Ubl conjugation pathway.
FT   CHAIN           1..616
FT                   /note="Kelch-like protein 36"
FT                   /id="PRO_0000274690"
FT   DOMAIN          46..113
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          148..250
FT                   /note="BACK"
FT   REPEAT          296..345
FT                   /note="Kelch 1"
FT   REPEAT          346..397
FT                   /note="Kelch 2"
FT   REPEAT          398..444
FT                   /note="Kelch 3"
FT   REPEAT          446..493
FT                   /note="Kelch 4"
FT   REPEAT          494..546
FT                   /note="Kelch 5"
FT   REPEAT          547..595
FT                   /note="Kelch 6"
SQ   SEQUENCE   616 AA;  69717 MW;  9773FA62830AAC52 CRC64;
     MMEGSRQTRV SRPYKISESS KVYRWAEHSG TVLQRLNEQR LRGLFCDVVL VADEQRLPAH
     RNLLAVCSDY FNSMFTLGMR EAFQKEVELI GASYIGLKAV VDFLYGGELV LDGGNIDYVL
     ETAHLLQIWT AVDFCCEYLE QEVSEDNYLY LQELASIYSL KRLDAFIDSF ILSRFGTLSF
     TPAFLQNISM QKLCAYLGSS EVQRECEHDL LQAALQWLTQ QPEREAHAYQ VLENIHFPLI
     PKNDLLHRVK PAVCSLLPRE ANCEGFIEEA VRYHNSLAAQ PVMQTKRTAL RTTQECLLFV
     GGEVSERCLE LSDDTCYLDA QSEQWVKETP LPARRSHHCV AVLGGFIFIA GGSFSRDNGG
     DAASNLLYRY DPRCKQWIKV ASMNQRRVDF YLASIEDMLV AVGGRNENGA LSSVETYSPK
     TDSWSYVAGL PRFTYGHAGT IYKDFVYISG GHDYQIGPYR KNLLCYDHRT DVWEERRPMS
     TARGWHSMCS LGDSIYSIGG SDDSLESMER FDVLGVEAYS PQCNQWTRVA PLLHANSESG
     VAVWEGRIYI LGGYSWENTA FSKTVQVYDR DKDKWSEGTE LPKAIAGVSA CVCALKPRLE
     DKKKKGKGKR PQDHGQ