ID   KLH36_DANRE             Reviewed;         605 AA.
AC   Q503R4;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Kelch-like protein 36;
GN   Name=klhl36; ORFNames=zgc:110268;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable substrate-specific adapter of an E3 ubiquitin-
CC       protein ligase complex which mediates the ubiquitination and subsequent
CC       proteasomal degradation of target proteins. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
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DR   EMBL; BC095214; AAH95214.1; -; mRNA.
DR   RefSeq; NP_001018416.1; NM_001020580.1.
DR   AlphaFoldDB; Q503R4; -.
DR   SMR; Q503R4; -.
DR   STRING; 7955.ENSDARP00000039584; -.
DR   PaxDb; Q503R4; -.
DR   GeneID; 553604; -.
DR   KEGG; dre:553604; -.
DR   CTD; 79786; -.
DR   ZFIN; ZDB-GENE-050522-324; klhl36.
DR   eggNOG; KOG4441; Eukaryota.
DR   InParanoid; Q503R4; -.
DR   OrthoDB; 250404at2759; -.
DR   PhylomeDB; Q503R4; -.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q503R4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0097602; F:cullin family protein binding; IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR017096; BTB-kelch_protein.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR030585; KLHL36.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR45632:SF4; PTHR45632:SF4; 1.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 4.
DR   PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 6.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Kelch repeat; Reference proteome; Repeat; Ubl conjugation pathway.
FT   CHAIN           1..605
FT                   /note="Kelch-like protein 36"
FT                   /id="PRO_0000274694"
FT   DOMAIN          45..112
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          147..248
FT                   /note="BACK"
FT   REPEAT          295..344
FT                   /note="Kelch 1"
FT   REPEAT          346..396
FT                   /note="Kelch 2"
FT   REPEAT          397..443
FT                   /note="Kelch 3"
FT   REPEAT          445..493
FT                   /note="Kelch 4"
FT   REPEAT          494..546
FT                   /note="Kelch 5"
FT   REPEAT          547..595
FT                   /note="Kelch 6"
SQ   SEQUENCE   605 AA;  68470 MW;  C42949D0ECE9A283 CRC64;
     MEIGKQTRLS RPHRLSESSK VYRWADQANN LLQGLNEQRQ HGQMCDVVLV ADDQRIPAHR
     ALLAVSSPYF QAMFTLGMRE EHESEIELVG ASYVGVKAVI DFLYSGNLPL DGGNIDYVLE
     TAHLLQVWQA VDFCCQYLEK EVREDNYLYL QELALLYSLD RLDAFIDRFI LKHFSTLAIT
     SEFLQDVRMF KLCAYLSSEQ VQCLNEETLF EVAFKWLKQK PERLEFALQL LSNIRFALIP
     FYLLKYYVLP NLHSLLPLDT SCKVLVEEAI DYHRKLSAQP VMQTQRTGLR GGVECLLLLG
     GEVSERGEGL SAEVCWLDEE AGKWVEETKM PAPRSQHCVA VLGGFIFTAG GSCSPDNGGD
     SASDMLYRYD PRRCHWIKGA PMNQRRVDFY LGTMGECLIA VGGRNDSGPL SSVEVYHPAD
     DHWTYVAELP KFTYGHAGTI HKGIVYISGG HDYQIGPYRH DMLSYDPKTA DAWNECQAMI
     LARGWHSMAS LEDRIYAIGG SDDHEDSMER FDVLEVEAFD PQTNQWTMIA PLRYASSEAG
     LAVLNRKIYV LGGYSWETMD FSQGTQVFDP DKEQWTLGPN LPKHIAGPSC VCLIEPELID
     SIDTE