KLH36_HUMAN
ID KLH36_HUMAN Reviewed; 616 AA.
AC Q8N4N3; Q8N5G6; Q9H9U6;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Kelch-like protein 36;
GN Name=KLHL36; Synonyms=C16orf44;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Blood;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE, AND INTERACTION WITH CUL3.
RX PubMed=14528312; DOI=10.1038/ncb1056;
RA Furukawa M., He Y.J., Borchers C., Xiong Y.;
RT "Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin
RT ligases.";
RL Nat. Cell Biol. 5:1001-1007(2003).
CC -!- FUNCTION: Probable substrate-specific adapter of an E3 ubiquitin-
CC protein ligase complex which mediates the ubiquitination and subsequent
CC proteasomal degradation of target proteins.
CC {ECO:0000269|PubMed:14528312}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Interacts with CUL3. {ECO:0000269|PubMed:14528312}.
CC -!- INTERACTION:
CC Q8N4N3; P07686: HEXB; NbExp=3; IntAct=EBI-6426427, EBI-7133736;
CC Q8N4N3-2; P54253: ATXN1; NbExp=6; IntAct=EBI-10973851, EBI-930964;
CC Q8N4N3-2; P55212: CASP6; NbExp=3; IntAct=EBI-10973851, EBI-718729;
CC Q8N4N3-2; P55210: CASP7; NbExp=3; IntAct=EBI-10973851, EBI-523958;
CC Q8N4N3-2; O00291: HIP1; NbExp=3; IntAct=EBI-10973851, EBI-473886;
CC Q8N4N3-2; P13473-2: LAMP2; NbExp=3; IntAct=EBI-10973851, EBI-21591415;
CC Q8N4N3-2; P07237: P4HB; NbExp=3; IntAct=EBI-10973851, EBI-395883;
CC Q8N4N3-2; P60201-2: PLP1; NbExp=3; IntAct=EBI-10973851, EBI-12188331;
CC Q8N4N3-2; O75400-2: PRPF40A; NbExp=3; IntAct=EBI-10973851, EBI-5280197;
CC Q8N4N3-2; P00441: SOD1; NbExp=3; IntAct=EBI-10973851, EBI-990792;
CC Q8N4N3-2; Q9P1I4: ST13; NbExp=3; IntAct=EBI-10973851, EBI-25892254;
CC Q8N4N3-2; Q13148: TARDBP; NbExp=6; IntAct=EBI-10973851, EBI-372899;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N4N3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N4N3-2; Sequence=VSP_022867;
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DR EMBL; AK022605; BAB14124.1; -; mRNA.
DR EMBL; BC032400; AAH32400.1; -; mRNA.
DR EMBL; BC033821; AAH33821.1; -; mRNA.
DR CCDS; CCDS10948.1; -. [Q8N4N3-1]
DR CCDS; CCDS76909.1; -. [Q8N4N3-2]
DR RefSeq; NP_001290380.1; NM_001303451.1. [Q8N4N3-2]
DR RefSeq; NP_079007.2; NM_024731.3. [Q8N4N3-1]
DR RefSeq; XP_005256206.1; XM_005256149.2. [Q8N4N3-1]
DR RefSeq; XP_016879163.1; XM_017023674.1.
DR RefSeq; XP_016879164.1; XM_017023675.1.
DR AlphaFoldDB; Q8N4N3; -.
DR SMR; Q8N4N3; -.
DR BioGRID; 122886; 66.
DR IntAct; Q8N4N3; 34.
DR STRING; 9606.ENSP00000456743; -.
DR GlyGen; Q8N4N3; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q8N4N3; -.
DR PhosphoSitePlus; Q8N4N3; -.
DR BioMuta; KLHL36; -.
DR DMDM; 74728879; -.
DR EPD; Q8N4N3; -.
DR jPOST; Q8N4N3; -.
DR MassIVE; Q8N4N3; -.
DR MaxQB; Q8N4N3; -.
DR PaxDb; Q8N4N3; -.
DR PeptideAtlas; Q8N4N3; -.
DR PRIDE; Q8N4N3; -.
DR ProteomicsDB; 71948; -. [Q8N4N3-1]
DR ProteomicsDB; 71949; -. [Q8N4N3-2]
DR Antibodypedia; 17099; 90 antibodies from 23 providers.
DR DNASU; 79786; -.
DR Ensembl; ENST00000258157.9; ENSP00000258157.5; ENSG00000135686.13. [Q8N4N3-2]
DR Ensembl; ENST00000564996.6; ENSP00000456743.1; ENSG00000135686.13. [Q8N4N3-1]
DR GeneID; 79786; -.
DR KEGG; hsa:79786; -.
DR MANE-Select; ENST00000564996.6; ENSP00000456743.1; NM_024731.4; NP_079007.2.
DR UCSC; uc002fig.4; human. [Q8N4N3-1]
DR CTD; 79786; -.
DR GeneCards; KLHL36; -.
DR HGNC; HGNC:17844; KLHL36.
DR HPA; ENSG00000135686; Low tissue specificity.
DR neXtProt; NX_Q8N4N3; -.
DR OpenTargets; ENSG00000135686; -.
DR PharmGKB; PA162393612; -.
DR VEuPathDB; HostDB:ENSG00000135686; -.
DR eggNOG; KOG4441; Eukaryota.
DR GeneTree; ENSGT00940000157543; -.
DR HOGENOM; CLU_004253_14_3_1; -.
DR InParanoid; Q8N4N3; -.
DR OMA; QYPEREN; -.
DR OrthoDB; 250404at2759; -.
DR PhylomeDB; Q8N4N3; -.
DR TreeFam; TF328485; -.
DR PathwayCommons; Q8N4N3; -.
DR SignaLink; Q8N4N3; -.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 79786; 15 hits in 1117 CRISPR screens.
DR ChiTaRS; KLHL36; human.
DR GenomeRNAi; 79786; -.
DR Pharos; Q8N4N3; Tdark.
DR PRO; PR:Q8N4N3; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q8N4N3; protein.
DR Bgee; ENSG00000135686; Expressed in seminal vesicle and 184 other tissues.
DR ExpressionAtlas; Q8N4N3; baseline and differential.
DR Genevisible; Q8N4N3; HS.
DR GO; GO:0097602; F:cullin family protein binding; IPI:UniProtKB.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 2.120.10.80; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR030585; KLHL36.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR45632:SF4; PTHR45632:SF4; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 4.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF117281; SSF117281; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Kelch repeat; Reference proteome; Repeat;
KW Ubl conjugation pathway.
FT CHAIN 1..616
FT /note="Kelch-like protein 36"
FT /id="PRO_0000274691"
FT DOMAIN 46..113
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 148..250
FT /note="BACK"
FT REPEAT 296..345
FT /note="Kelch 1"
FT REPEAT 346..397
FT /note="Kelch 2"
FT REPEAT 398..444
FT /note="Kelch 3"
FT REPEAT 446..493
FT /note="Kelch 4"
FT REPEAT 494..546
FT /note="Kelch 5"
FT REPEAT 547..595
FT /note="Kelch 6"
FT REGION 597..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 369..431
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_022867"
FT CONFLICT 494
FT /note="S -> G (in Ref. 1; BAB14124)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 616 AA; 69896 MW; D2504144EF34C80F CRC64;
MMEGSRQTRV SRPYKISESS KVYRWADHSS TVLQRLNEQR LRGLFCDVVL VADEQRVPAH
RNLLAVCSDY FNSMFTIGMR EAFQKEVELI GASYIGLKAV VDFLYGGELV LDGGNIDYVL
ETAHLLQIWT VVDFCCEYLE QEVSEDNYLY LQELASIYSL KRLDAFIDGF ILNHFGTLSF
TPDFLQNVSM QKLCVYLSSS EVQRECEHDL LQAALQWLTQ QPEREAHARQ VLENIHFPLI
PKNDLLHRVK PAVCSLLPKE ANCEGFIEEA VRYHNNLAAQ PVMQTKRTAL RTNQERLLFV
GGEVSERCLE LSDDTCYLDA KSEQWVKETP LPARRSHHCV AVLGGFIFIA GGSFSRDNGG
DAASNLLYRY DPRCKQWIKV ASMNQRRVDF YLASIEDMLV AIGGRNENGA LSSVETYSPK
TDSWSYVAGL PRFTYGHAGT IYKDFVYISG GHDYQIGPYR KNLLCYDHRT DVWEERRPMT
TARGWHSMCS LGDSIYSIGG SDDNIESMER FDVLGVEAYS PQCNQWTRVA PLLHANSESG
VAVWEGRIYI LGGYSWENTA FSKTVQVYDR EADKWSRGVD LPKAIAGGSA CVCALEPRPE
DKKKKGKGKR HQDRGQ
