KLH36_MOUSE
ID KLH36_MOUSE Reviewed; 613 AA.
AC Q8R124; Q3U0B9; Q6KAS2;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Kelch-like protein 36;
GN Name=Klhl36;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen;
RX PubMed=15449545; DOI=10.1093/dnares/11.2.127;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Kitamura H., Nakagawa T., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of FLJ genes: the
RT complete nucleotide sequences of 110 mouse FLJ-homologous cDNAs identified
RT by screening of terminal sequences of cDNA clones randomly sampled from
RT size-fractionated libraries.";
RL DNA Res. 11:127-135(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Probable substrate-specific adapter of an E3 ubiquitin-
CC protein ligase complex which mediates the ubiquitination and subsequent
CC proteasomal degradation of target proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Interacts with CUL3. {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD21385.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK131135; BAD21385.1; ALT_INIT; mRNA.
DR EMBL; AK157027; BAE33936.1; -; mRNA.
DR EMBL; BC025816; AAH25816.1; -; mRNA.
DR CCDS; CCDS22713.1; -.
DR RefSeq; NP_666331.1; NM_146219.1.
DR AlphaFoldDB; Q8R124; -.
DR SMR; Q8R124; -.
DR BioGRID; 231580; 1.
DR STRING; 10090.ENSMUSP00000034287; -.
DR iPTMnet; Q8R124; -.
DR PhosphoSitePlus; Q8R124; -.
DR EPD; Q8R124; -.
DR MaxQB; Q8R124; -.
DR PaxDb; Q8R124; -.
DR PRIDE; Q8R124; -.
DR ProteomicsDB; 265005; -.
DR Antibodypedia; 17099; 90 antibodies from 23 providers.
DR DNASU; 234796; -.
DR Ensembl; ENSMUST00000034287; ENSMUSP00000034287; ENSMUSG00000031828.
DR GeneID; 234796; -.
DR KEGG; mmu:234796; -.
DR UCSC; uc009nql.1; mouse.
DR CTD; 79786; -.
DR MGI; MGI:2385305; Klhl36.
DR VEuPathDB; HostDB:ENSMUSG00000031828; -.
DR eggNOG; KOG4441; Eukaryota.
DR GeneTree; ENSGT00940000157543; -.
DR HOGENOM; CLU_004253_14_3_1; -.
DR InParanoid; Q8R124; -.
DR OMA; QYPEREN; -.
DR OrthoDB; 250404at2759; -.
DR PhylomeDB; Q8R124; -.
DR TreeFam; TF328485; -.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 234796; 0 hits in 72 CRISPR screens.
DR PRO; PR:Q8R124; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8R124; protein.
DR Bgee; ENSMUSG00000031828; Expressed in retinal neural layer and 89 other tissues.
DR Genevisible; Q8R124; MM.
DR GO; GO:0097602; F:cullin family protein binding; ISO:MGI.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 2.120.10.80; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR030585; KLHL36.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR45632:SF4; PTHR45632:SF4; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 4.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF117281; SSF117281; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 1: Evidence at protein level;
KW Kelch repeat; Reference proteome; Repeat; Ubl conjugation pathway.
FT CHAIN 1..613
FT /note="Kelch-like protein 36"
FT /id="PRO_0000274692"
FT DOMAIN 45..112
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 147..249
FT /note="BACK"
FT REPEAT 294..343
FT /note="Kelch 1"
FT REPEAT 344..395
FT /note="Kelch 2"
FT REPEAT 396..442
FT /note="Kelch 3"
FT REPEAT 444..491
FT /note="Kelch 4"
FT REPEAT 492..544
FT /note="Kelch 5"
FT REPEAT 545..593
FT /note="Kelch 6"
FT CONFLICT 372
FT /note="R -> C (in Ref. 2; BAE33936)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 613 AA; 69950 MW; 4A87476330E5B3DC CRC64;
MEASKQMRVS RPYKISESSK VYHWPDHSTA VLQRLNEQRL HGLFCDVVLV VEEQQVPAHR
NLLAVCSDYF NSMFTLGMRE AFQKEVELVG TSYVGLKAVV DFLYSSELEL DGSNIDYILE
TAHLLQIWTV VDFCCEYLEQ EVSEDNYLYL QELASIYSLK RLDAFIDSFV LSHFSTLSFT
PDFLQSISVQ KLCVYLSSGQ VQHKWEYDLL QVALQWLTQQ PEREVHTRRV LENIRFPLFP
EDILLQRVKL AMCSLLPSEA NGEGFVEEAM HYHNSLVAQP VLQTKRTLLR SEECLLFVGG
EVSERCLELS DDTCYLDTKN EQWVKETSLP ARRSHHCVAV LGGFIFIAGG SFSRDNGGNA
ASNLLYRYDP RRKQWIKVAS MNQRRVDFYL ASIEDMLVAV GGRNENGALS SVETYSPKTN
SWTYVAGLPR FTYGHAGTIY KDFVYISGGH DYQIGPYRKN LLCYDHRTDV WEERRPMTTA
RGWHSMCSLG DSIYSIGGSD DHMESMERFD VLGVEAYSPQ CNQWTRVAPL LQANSESGVA
VWQGRIYILG GYSWESTAFS RAVQVYDSEA NRWSRGPDLP NAIAGVSACV CALNPRLEEK
KKRNKDKCQD RGQ
