ID   KLH36_RAT               Reviewed;         613 AA.
AC   Q66HD2;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Kelch-like protein 36;
GN   Name=Klhl36;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Probable substrate-specific adapter of an E3 ubiquitin-
CC       protein ligase complex which mediates the ubiquitination and subsequent
CC       proteasomal degradation of target proteins. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Interacts with CUL3. {ECO:0000250}.
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DR   EMBL; BC081914; AAH81914.1; -; mRNA.
DR   RefSeq; NP_001017511.1; NM_001017511.1.
DR   RefSeq; XP_006255780.1; XM_006255718.2.
DR   AlphaFoldDB; Q66HD2; -.
DR   SMR; Q66HD2; -.
DR   STRING; 10116.ENSRNOP00000022091; -.
DR   iPTMnet; Q66HD2; -.
DR   PhosphoSitePlus; Q66HD2; -.
DR   jPOST; Q66HD2; -.
DR   PaxDb; Q66HD2; -.
DR   PRIDE; Q66HD2; -.
DR   Ensembl; ENSRNOT00000022091; ENSRNOP00000022091; ENSRNOG00000016422.
DR   GeneID; 498957; -.
DR   KEGG; rno:498957; -.
DR   UCSC; RGD:1561366; rat.
DR   CTD; 79786; -.
DR   RGD; 1561366; Klhl36.
DR   eggNOG; KOG4441; Eukaryota.
DR   GeneTree; ENSGT00940000157543; -.
DR   HOGENOM; CLU_004253_14_3_1; -.
DR   InParanoid; Q66HD2; -.
DR   OMA; QYPEREN; -.
DR   OrthoDB; 250404at2759; -.
DR   PhylomeDB; Q66HD2; -.
DR   TreeFam; TF328485; -.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q66HD2; -.
DR   Proteomes; UP000002494; Chromosome 19.
DR   Bgee; ENSRNOG00000016422; Expressed in testis and 18 other tissues.
DR   Genevisible; Q66HD2; RN.
DR   GO; GO:0097602; F:cullin family protein binding; ISO:RGD.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR017096; BTB-kelch_protein.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR030585; KLHL36.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR45632:SF4; PTHR45632:SF4; 1.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 4.
DR   PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 6.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Kelch repeat; Reference proteome; Repeat; Ubl conjugation pathway.
FT   CHAIN           1..613
FT                   /note="Kelch-like protein 36"
FT                   /id="PRO_0000274693"
FT   DOMAIN          45..112
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          147..249
FT                   /note="BACK"
FT   REPEAT          294..343
FT                   /note="Kelch 1"
FT   REPEAT          344..395
FT                   /note="Kelch 2"
FT   REPEAT          396..442
FT                   /note="Kelch 3"
FT   REPEAT          444..491
FT                   /note="Kelch 4"
FT   REPEAT          492..544
FT                   /note="Kelch 5"
FT   REPEAT          545..593
FT                   /note="Kelch 6"
SQ   SEQUENCE   613 AA;  69935 MW;  3C57095D11BD4328 CRC64;
     MEASKQMRVS RPYKISESSK VYHWPGHSTT VLQRLNEQRL HGLFCDVVLV VEEQQVPAHR
     NLLAVCSDYF NSMFTLGMRE AFQKEVELVG TSYVGLKAVV DFLYSSELEL DGSNIDYILE
     TAHLLQIWTV VDFCCEYLEQ EVSEDNYLYL QELASIYSLK RLDAFIDSFV LNHFSTLSFT
     PDFLQTVSVQ KLCIYLSSGQ VQHTWEYDLL QAALQWLTQQ PEREVHTCRV LENIRFPLFP
     EDILLQRVKL AMCSLLPSEA NGEGFVEEAM HYHNSLVAQP VLQTKRTLLR SEECLLFVGG
     EVSERCLELS DDTCYLDTKN EQWVKETSLP ARRSHHCVAV LGGFIFVAGG SFSRDNGGNA
     ASNLLYRYDP RRKQWIKVAS MNQRRVDFYL ASIEDMLVAV GGRNENGALS SVETYSPKTN
     SWTYVAGLPR FTYGHAGTIY KDFVYISGGH DYQIGPYRKN LLCYDHRTDV WEERRPMTTA
     RGWHSMCSLG DSIYSIGGSD DHMESMERFD VLGVEAYSPQ CNQWTRVAPL LQANSESGVA
     VWQGRIYILG GYSWESTAFS RAVQVYDREA NRWSRGPDLP NAIAGVSACV CALNPRLEEK
     KKKNKDKRQD RGQ