ID   KLH38_DANRE             Reviewed;         583 AA.
AC   Q1LYM6;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Kelch-like protein 38;
GN   Name=klhl38; ORFNames=si:dkey-5e12.1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
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DR   EMBL; BX004966; CAK11118.1; -; Genomic_DNA.
DR   RefSeq; NP_001038350.1; NM_001044885.1.
DR   RefSeq; XP_005159683.1; XM_005159626.3.
DR   RefSeq; XP_009292600.1; XM_009294325.2.
DR   AlphaFoldDB; Q1LYM6; -.
DR   SMR; Q1LYM6; -.
DR   STRING; 7955.ENSDARP00000052077; -.
DR   PaxDb; Q1LYM6; -.
DR   Ensembl; ENSDART00000052078; ENSDARP00000052077; ENSDARG00000031383.
DR   Ensembl; ENSDART00000177791; ENSDARP00000143526; ENSDARG00000116001.
DR   GeneID; 559083; -.
DR   KEGG; dre:559083; -.
DR   CTD; 559083; -.
DR   ZFIN; ZDB-GENE-060503-737; klhl38a.
DR   eggNOG; KOG4441; Eukaryota.
DR   GeneTree; ENSGT00940000157647; -.
DR   HOGENOM; CLU_004253_14_6_1; -.
DR   InParanoid; Q1LYM6; -.
DR   OMA; CLTLQCV; -.
DR   OrthoDB; 292812at2759; -.
DR   PhylomeDB; Q1LYM6; -.
DR   TreeFam; TF329218; -.
DR   PRO; PR:Q1LYM6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 19.
DR   Bgee; ENSDARG00000031383; Expressed in muscle tissue and 5 other tissues.
DR   ExpressionAtlas; Q1LYM6; baseline.
DR   Gene3D; 2.120.10.80; -; 2.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR017096; BTB-kelch_protein.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR030568; KLHL38.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR24412:SF462; PTHR24412:SF462; 1.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 4.
DR   PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 6.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   4: Predicted;
KW   Kelch repeat; Reference proteome; Repeat.
FT   CHAIN           1..583
FT                   /note="Kelch-like protein 38"
FT                   /id="PRO_0000325812"
FT   DOMAIN          34..101
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          136..237
FT                   /note="BACK"
FT   REPEAT          285..332
FT                   /note="Kelch 1"
FT   REPEAT          333..385
FT                   /note="Kelch 2"
FT   REPEAT          386..433
FT                   /note="Kelch 3"
FT   REPEAT          435..481
FT                   /note="Kelch 4"
FT   REPEAT          482..523
FT                   /note="Kelch 5"
FT   REPEAT          525..575
FT                   /note="Kelch 6"
SQ   SEQUENCE   583 AA;  66842 MW;  54E03796FD1C7CB4 CRC64;
     MASTSTEVFP FKDQELSTQL LFQLNILRQE QIFTDVILCT EDKEIPCHRN VLVSSSPYFR
     AMFCSNFRES SQARVDLKGI ASEVIECVVD YIYTGSITIT MELVLPLMQA ASMLQYGRLF
     EACSTFLQEQ LNPENCLSMI RLSEILHCET LKERAKEMAV RCFSDVAASE DFCELTLPEL
     MCYLEDDRLC AEEEQVFETL LAWIHHDPFS RRGAIHDLFK KVRLRFIHPT YLFQFIANDP
     LVQSSTLCTE IIESVRRLMF SVSAKCTKEL KPLWTTPRRY TCRETLVVVG GRKNNEQTSR
     EALLYDERTQ RWQWLAKLPL RLYKAAYVCI HSILYVVGGL SLSLVSGDSA VSATVYTLSL
     KTNQWRTAEP MLEPRYAHQC VSYLHFIFAL GGIGQDKQIS NTVERYNSMF NQWEVMAPMP
     TAVLHPAVAA NDQRIYVFGG EDALQNPVRL IQVYHISRNL WSRLETRTVK NVCAPAAVIE
     DKIYIVGGYT RRVIAYDTKA NKFVKCTNMK ERRMHHAATV INNKLYVTGG RFLNSHDVIE
     DSDCFECYDP KTDVWTSKGS LPYKLFDHGS LPLICVSNRP NPP