KLH38_MOUSE
ID KLH38_MOUSE Reviewed; 581 AA.
AC Q8BSF5;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Kelch-like protein 38;
GN Name=Klhl38;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AK033353; BAC28242.1; -; mRNA.
DR EMBL; BC132483; AAI32484.1; -; mRNA.
DR EMBL; BC145690; AAI45691.1; -; mRNA.
DR CCDS; CCDS27492.1; -.
DR RefSeq; NP_808423.1; NM_177755.3.
DR AlphaFoldDB; Q8BSF5; -.
DR SMR; Q8BSF5; -.
DR BioGRID; 234560; 7.
DR STRING; 10090.ENSMUSP00000022985; -.
DR iPTMnet; Q8BSF5; -.
DR PhosphoSitePlus; Q8BSF5; -.
DR jPOST; Q8BSF5; -.
DR PaxDb; Q8BSF5; -.
DR PRIDE; Q8BSF5; -.
DR Antibodypedia; 27017; 99 antibodies from 15 providers.
DR DNASU; 268807; -.
DR Ensembl; ENSMUST00000022985; ENSMUSP00000022985; ENSMUSG00000022357.
DR GeneID; 268807; -.
DR KEGG; mmu:268807; -.
DR UCSC; uc007vtl.1; mouse.
DR CTD; 340359; -.
DR MGI; MGI:3045310; Klhl38.
DR VEuPathDB; HostDB:ENSMUSG00000022357; -.
DR eggNOG; KOG4441; Eukaryota.
DR GeneTree; ENSGT00940000157647; -.
DR HOGENOM; CLU_004253_14_6_1; -.
DR InParanoid; Q8BSF5; -.
DR OMA; CLTLQCV; -.
DR OrthoDB; 292812at2759; -.
DR PhylomeDB; Q8BSF5; -.
DR TreeFam; TF329218; -.
DR BioGRID-ORCS; 268807; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q8BSF5; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q8BSF5; protein.
DR Bgee; ENSMUSG00000022357; Expressed in hindlimb stylopod muscle and 29 other tissues.
DR Gene3D; 2.120.10.80; -; 2.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR030568; KLHL38.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR24412:SF462; PTHR24412:SF462; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 3.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 5.
DR SUPFAM; SSF117281; SSF117281; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 2: Evidence at transcript level;
KW Kelch repeat; Reference proteome; Repeat.
FT CHAIN 1..581
FT /note="Kelch-like protein 38"
FT /id="PRO_0000325810"
FT DOMAIN 34..101
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 136..237
FT /note="BACK"
FT REPEAT 285..332
FT /note="Kelch 1"
FT REPEAT 334..383
FT /note="Kelch 2"
FT REPEAT 384..431
FT /note="Kelch 3"
FT REPEAT 433..479
FT /note="Kelch 4"
FT REPEAT 480..521
FT /note="Kelch 5"
FT REPEAT 523..573
FT /note="Kelch 6"
SQ SEQUENCE 581 AA; 65651 MW; B04BE2F8ED9D701C CRC64;
MDEELPDGVV FKDHSFSSDL LRQLNGLRQS KILTDVSICS GAWEVPCHRS VLASSSPYFK
AMFCSHFRES REAKVQMKGI SSTTLEQVIT YVYTGEVHIS AANVLPLMEA AAMLQYPRVF
EACSSYLQSQ LAPSNCLGLV RLAEILSCDS LKKKAKEVAL TYFPEVAASA DLKELCAMEL
RDYLGDDRLC GEEEKVFEAL MAWVKHDLQA RWRHMQELLQ QVRLQYIHPA FFHHFIANDA
LLQSSPACQA ILEMARKQIF SLYGPSAQDC KLLWRMPPRS SYQDFLLLLG GRKDNQQTTR
DVLLYSGQTG QWQSLAKLPI RLYKASAVTL HRSVYVLGGM TVSEGKSLIS CGVYIFSLKL
NQWRVGEPML AARYSHRSTT HRNFIFSIGG TGEGQELLAS MERYDSIRDV WESMAGMPVA
VLHPAVAVKD QRLYLFGGED IMQNPVRLIQ VYHISRNTWY KMETRMIKNV CAPAVVLGEQ
IVIVGGYTRR ILAYDPQSNK FVKCADMKDR RMHHGATVMG NKLYVTGGRR LTTDCNIEDS
ASFDCYDPET DTWTSQGQLP HKLFDHACLT LQCIPHMTSL S
