ID   KLH40_XENLA             Reviewed;         614 AA.
AC   Q5U504;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Kelch-like protein 40;
DE   AltName: Full=Kelch repeat and BTB domain-containing protein 5;
GN   Name=klhl40; Synonyms=kbtbd5;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3
CC       ubiquitin ligase complex that acts as a key regulator of skeletal
CC       muscle development. {ECO:0000250|UniProtKB:Q9D783}.
CC   -!- SUBUNIT: Component of the BCR(KLHL40) E3 ubiquitin ligase complex.
CC       {ECO:0000250|UniProtKB:Q9D783}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9D783}.
CC       Cytoplasm, myofibril, sarcomere, A band {ECO:0000250|UniProtKB:Q9D783}.
CC       Cytoplasm, myofibril, sarcomere, I band {ECO:0000250|UniProtKB:Q9D783}.
CC   -!- SIMILARITY: Belongs to the KLHL40 family. {ECO:0000305}.
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DR   EMBL; BC084883; AAH84883.1; -; mRNA.
DR   RefSeq; NP_001090465.1; NM_001096996.1.
DR   AlphaFoldDB; Q5U504; -.
DR   SMR; Q5U504; -.
DR   DNASU; 779378; -.
DR   GeneID; 779378; -.
DR   KEGG; xla:779378; -.
DR   CTD; 779378; -.
DR   Proteomes; UP000186698; Chromosome 6S.
DR   Bgee; 779378; Expressed in muscle tissue and 7 other tissues.
DR   GO; GO:0031672; C:A band; IEA:UniProtKB-SubCell.
DR   GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0031674; C:I band; IEA:UniProtKB-SubCell.
DR   GO; GO:0031397; P:negative regulation of protein ubiquitination; IEA:InterPro.
DR   GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
DR   GO; GO:0031398; P:positive regulation of protein ubiquitination; ISS:UniProtKB.
DR   GO; GO:0048741; P:skeletal muscle fiber development; ISS:UniProtKB.
DR   GO; GO:0098528; P:skeletal muscle fiber differentiation; ISS:UniProtKB.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR017096; BTB-kelch_protein.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR030607; KLHL40.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR24412:SF22; PTHR24412:SF22; 1.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 3.
DR   PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 4.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Kelch repeat; Reference proteome; Repeat;
KW   Ubl conjugation pathway.
FT   CHAIN           1..614
FT                   /note="Kelch-like protein 40"
FT                   /id="PRO_0000274237"
FT   DOMAIN          33..100
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          135..237
FT                   /note="BACK"
FT   REPEAT          353..405
FT                   /note="Kelch 1"
FT   REPEAT          406..455
FT                   /note="Kelch 2"
FT   REPEAT          456..503
FT                   /note="Kelch 3"
FT   REPEAT          504..550
FT                   /note="Kelch 4"
FT   REPEAT          552..606
FT                   /note="Kelch 5"
SQ   SEQUENCE   614 AA;  69700 MW;  8FE160BB38B8B8FA CRC64;
     MALPTQQSEE LRLYQQTLLQ DGLKDMLDHN NFIDCVLKIQ GKEFPCHRLV LASCSPYFRA
     MFLSDLEESK KKEIDLEDVD PDVMGKILHY IYTSEIEITE KNVQDIFSVA NMFQIPSIFT
     VCVSFLQKKL CLSNCLAIFR LGLLLDCPRL AVSARDFVCD RFNLIARDSE LYELSPDELI
     AVISSDSLNI EKEEDVFEVV MKWASKEKEK RTKALPVIFE SIRFCLIPQD YIKNKVEKHE
     LVKPNKELLK KLQIVKDAQQ GKLPSLKKKT SAKASEGKDG EQVVNGELDE EEEALPGILN
     DTLRFGMFLK DMIFMISDTG AVAYDPSANE CFFASLSAQI PKNHVSLATK ENQLFVAGGL
     YYNEESKEEP LSSYFLQFDH LDSDWLGMPP VPSARCLFGL GESENSIYLI GGKELKEGEQ
     MLDSVLCYDR PSFKWGESDP LPYKVYGHTV VSHDNLVYVL GGKGNEKKCL KRVCVYNPKK
     FEWKDLAPMK TGRSLFGATV HKGKIFIAAG VTDTGLTNTI EAYDIKTNKW EDFTEFPQER
     SSLSLVSMNG TLYAIGGFAT IENESEELVP TELNDIWRFN EEEKKWEGIL REIRYASGAT
     FIAARLNILR LTKM