ID   KLH40_XENTR             Reviewed;         614 AA.
AC   Q5EB39;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Kelch-like protein 40;
DE   AltName: Full=Kelch repeat and BTB domain-containing protein 5;
GN   Name=klhl40; Synonyms=kbtbd5;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3
CC       ubiquitin ligase complex that acts as a key regulator of skeletal
CC       muscle development. {ECO:0000250|UniProtKB:Q9D783}.
CC   -!- SUBUNIT: Component of the BCR(KLHL40) E3 ubiquitin ligase complex.
CC       {ECO:0000250|UniProtKB:Q9D783}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9D783}.
CC       Cytoplasm, myofibril, sarcomere, A band {ECO:0000250|UniProtKB:Q9D783}.
CC       Cytoplasm, myofibril, sarcomere, I band {ECO:0000250|UniProtKB:Q9D783}.
CC   -!- SIMILARITY: Belongs to the KLHL40 family. {ECO:0000305}.
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DR   EMBL; BC090098; AAH90098.1; -; mRNA.
DR   RefSeq; NP_001015817.1; NM_001015817.1.
DR   RefSeq; XP_012820108.1; XM_012964654.2.
DR   AlphaFoldDB; Q5EB39; -.
DR   SMR; Q5EB39; -.
DR   STRING; 8364.ENSXETP00000013576; -.
DR   PaxDb; Q5EB39; -.
DR   PRIDE; Q5EB39; -.
DR   DNASU; 548534; -.
DR   GeneID; 548534; -.
DR   KEGG; xtr:548534; -.
DR   CTD; 131377; -.
DR   Xenbase; XB-GENE-968841; klhl40.
DR   eggNOG; KOG4441; Eukaryota.
DR   HOGENOM; CLU_004253_14_4_1; -.
DR   InParanoid; Q5EB39; -.
DR   OMA; PYVVYGH; -.
DR   OrthoDB; 946131at2759; -.
DR   PhylomeDB; Q5EB39; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000006168; Expressed in skeletal muscle tissue and 2 other tissues.
DR   GO; GO:0031672; C:A band; IBA:GO_Central.
DR   GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0031674; C:I band; IBA:GO_Central.
DR   GO; GO:0032435; P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   GO; GO:0031397; P:negative regulation of protein ubiquitination; IBA:GO_Central.
DR   GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
DR   GO; GO:0031398; P:positive regulation of protein ubiquitination; ISS:UniProtKB.
DR   GO; GO:0048741; P:skeletal muscle fiber development; ISS:UniProtKB.
DR   GO; GO:0098528; P:skeletal muscle fiber differentiation; ISS:UniProtKB.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR017096; BTB-kelch_protein.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR030607; KLHL40.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR24412:SF22; PTHR24412:SF22; 1.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 3.
DR   PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 4.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Kelch repeat; Reference proteome; Repeat;
KW   Ubl conjugation pathway.
FT   CHAIN           1..614
FT                   /note="Kelch-like protein 40"
FT                   /id="PRO_0000274238"
FT   DOMAIN          33..100
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          135..237
FT                   /note="BACK"
FT   REPEAT          353..405
FT                   /note="Kelch 1"
FT   REPEAT          406..455
FT                   /note="Kelch 2"
FT   REPEAT          456..503
FT                   /note="Kelch 3"
FT   REPEAT          505..550
FT                   /note="Kelch 4"
FT   REPEAT          552..606
FT                   /note="Kelch 5"
SQ   SEQUENCE   614 AA;  69547 MW;  1FE2543994947E58 CRC64;
     MALPTQQADE LRLYQQTLLQ DGLKDMLDHD NFIDCVLKIQ GKEFPCHRLV LAACSPYFRA
     MFLSNLEEGK KKEIDLEDVD PDVMGKILHY IYTSEIEITE KNVQDIFSVA NMFQIPSIFT
     VCVSFLQKKL CLSNCLAIFR LGLLLDCPRL AVSARDFVCD RFHLIARDEE FYDLSPDELI
     AVISSDSLNI EKEEEVFEVV LKWALKEKEK RAKALPIIFE SIRFRLIPQD YIKNKVEKHE
     LVKSDKELLK KLQMVKDAQE GKLPAAVKKT PSKASEGKDG EGVVNGDLEE EEEALPGILN
     DTLRFGMFLK DMIFMISDTG AVAYDPSANE CFFASLSAQI PKNHVSLATK ENQLFVAGGL
     YYNEENKDDP LSSYFLQFDH LDSDWLGMPP VPSARCLFGL GESDNSIYLI GGKELKEGEQ
     TLDTVLCYDR PSFKWGESDP LPYQVYGHTV VSHDNLVYVL GGKGNEKKCL KRVCVYNPKK
     FEWKDLAPMK TARSLFGSTV HKGKILIAAG VTDTGLTNTI EAYDVKTNKW EEFTEFPQER
     SSLSLVSMNG TLYAIGGFAT TENESGEFVP TELNDIWRFN EEEKKWEGIL REIRYASGAT
     FVAARLNILR LTKM