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KLHDB_AEDAE
ID   KLHDB_AEDAE             Reviewed;         589 AA.
AC   Q16RL8;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Kelch-like protein diablo {ECO:0000250|UniProtKB:Q9VUU5};
GN   Name=dbo {ECO:0000250|UniProtKB:Q9VUU5}; ORFNames=AAEL010911;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1] {ECO:0000312|EMBL:EAT37050.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Probable substrate-specific adapter of an E3 ubiquitin-
CC       protein ligase complex which mediates the ubiquitination and subsequent
CC       proteasomal degradation of target proteins. May have a role in synapse
CC       differentiation and growth (By similarity).
CC       {ECO:0000250|UniProtKB:Q9VUU5, ECO:0000250|UniProtKB:Q9Y2M5}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000250|UniProtKB:Q9Y2M5}.
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DR   EMBL; CH477704; EAT37050.1; -; Genomic_DNA.
DR   RefSeq; XP_001661146.1; XM_001661096.1.
DR   AlphaFoldDB; Q16RL8; -.
DR   SMR; Q16RL8; -.
DR   STRING; 7159.AAEL010911-PA; -.
DR   GeneID; 5574073; -.
DR   KEGG; aag:5574073; -.
DR   VEuPathDB; VectorBase:AAEL010911; -.
DR   eggNOG; KOG4441; Eukaryota.
DR   HOGENOM; CLU_004253_12_0_1; -.
DR   InParanoid; Q16RL8; -.
DR   OMA; NSWSPIV; -.
DR   OrthoDB; 731760at2759; -.
DR   PhylomeDB; Q16RL8; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000008820; Chromosome 3.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0045886; P:negative regulation of synaptic assembly at neuromuscular junction; ISS:UniProtKB.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR017096; BTB-kelch_protein.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 6.
DR   PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 6.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF50965; SSF50965; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   3: Inferred from homology;
KW   Actin-binding; Kelch repeat; Reference proteome; Repeat;
KW   Ubl conjugation pathway.
FT   CHAIN           1..589
FT                   /note="Kelch-like protein diablo"
FT                   /id="PRO_0000379942"
FT   DOMAIN          41..108
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          143..245
FT                   /note="BACK"
FT                   /evidence="ECO:0000255"
FT   REPEAT          292..338
FT                   /note="Kelch 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          340..386
FT                   /note="Kelch 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          387..433
FT                   /note="Kelch 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          435..480
FT                   /note="Kelch 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          482..527
FT                   /note="Kelch 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          528..574
FT                   /note="Kelch 6"
FT                   /evidence="ECO:0000255"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   589 AA;  66025 MW;  0357BA91DEB903F1 CRC64;
     MGDVLISDRP PSPARLSHTS EKHPRVTLTE LNVLRRHREL CDVVINVSGR KIFAHRVILS
     ACSPYFRAMF TGELEESRQT EVTIRDIDEN AMELLIDFCY TSHIVVEESN VQTLLPAACL
     LQLAEIQDIC CEFLKRQLDP TNCLGIRAFA DTHSCRELLR IADKFTQHNF QEVMESEEFL
     LLPVGQLVDI ICSDELNVRS EEQVFNAVMA WLKYNVAERR QHLAQVLQHV RMPLLSPKFL
     VGTVGSDLLV RSDEACRDLV DEAKNYLLLP QERPLMQGPR TRPRKPTRRG EVLFAVGGWC
     SGDAIASVER FDPETADWKM VAPMSKRRCG VGVAVLNDLL YAVGGHDGQS YLNSIERYDP
     QTNQWSCDVA PTTSCRTSVG VAVLDGFLYA VGGQDGVQCL NHVERYDPKE NKWSKVAPMT
     TRRLGVAVAV LGGYLYAIGG SDGQCPLNTV ERYDPRQNKW CAVSPMSTRR KHLGCAVFNN
     FIYAVGGRDD CMELSSAERY NPHTNSWSPI VAMTSRRSGV GLAVVNGQLY AVGGFDGTAY
     LKTIEVYDPE TNQWRLCGCM NYRRLGGGVG VMRAPQTENY MWIRKDSVV
 
 
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