KLHDB_ANOGA
ID KLHDB_ANOGA Reviewed; 582 AA.
AC Q7QGL0;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 4.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=Kelch-like protein diablo {ECO:0000250|UniProtKB:Q9VUU5};
GN Name=dbo {ECO:0000250|UniProtKB:Q9VUU5}; ORFNames=AGAP011587;
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST;
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
CC -!- FUNCTION: Probable substrate-specific adapter of an E3 ubiquitin-
CC protein ligase complex which mediates the ubiquitination and subsequent
CC proteasomal degradation of target proteins. May have a role in synapse
CC differentiation and growth (By similarity).
CC {ECO:0000250|UniProtKB:Q9VUU5, ECO:0000250|UniProtKB:Q9Y2M5}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000250|UniProtKB:Q9Y2M5}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAA05692.3; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AAAB01008834; EAA05692.3; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_309921.3; XM_309921.3.
DR AlphaFoldDB; Q7QGL0; -.
DR SMR; Q7QGL0; -.
DR STRING; 7165.AGAP011587-PA; -.
DR PaxDb; Q7QGL0; -.
DR GeneID; 1271172; -.
DR KEGG; aga:AgaP_AGAP011587; -.
DR CTD; 1271172; -.
DR VEuPathDB; VectorBase:AGAP011587; -.
DR eggNOG; KOG4441; Eukaryota.
DR HOGENOM; CLU_004253_14_2_1; -.
DR InParanoid; Q7QGL0; -.
DR OrthoDB; 731760at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000007062; Chromosome 3L.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0045886; P:negative regulation of synaptic assembly at neuromuscular junction; ISS:UniProtKB.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 2.120.10.80; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 6.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF117281; SSF117281; 2.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 3: Inferred from homology;
KW Actin-binding; Kelch repeat; Reference proteome; Repeat;
KW Ubl conjugation pathway.
FT CHAIN 1..582
FT /note="Kelch-like protein diablo"
FT /id="PRO_0000379943"
FT DOMAIN 41..108
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 143..245
FT /note="BACK"
FT /evidence="ECO:0000255"
FT REPEAT 292..338
FT /note="Kelch 1"
FT /evidence="ECO:0000255"
FT REPEAT 340..386
FT /note="Kelch 2"
FT /evidence="ECO:0000255"
FT REPEAT 387..433
FT /note="Kelch 3"
FT /evidence="ECO:0000255"
FT REPEAT 435..480
FT /note="Kelch 4"
FT /evidence="ECO:0000255"
FT REPEAT 482..527
FT /note="Kelch 5"
FT /evidence="ECO:0000255"
FT REPEAT 528..574
FT /note="Kelch 6"
FT /evidence="ECO:0000255"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 582 AA; 65253 MW; E86F97515C63C347 CRC64;
MGDVLISDRP PSPARLSHTS EKHPRVTLQE LNVLRRHREL CDVVINVKGR KIFAHRVILS
ACSPYFRAMF TGELEESRQT EVTICDIDEN AMELLIDFCY TSHIVVEESN VQPLLPAACL
LQLAEIQDIC CEFLKRQLDP ENCLGIRAFA DTHSCRELLR IADKFTQHNF QEVMESEEFL
LLPVGQLVDI ICSDELNVRS EEQVFNAVMA WLKYNVADRR QHLAQVLQHV RMPLLSPKFL
VGTVGSDLLV RSDEACRDLV DEAKNYLLLP QERPLMQGPR TRPRKPTRRG EVLFAVGGWC
SGDAIASVER FDPETADWKM VAPMSKRRCG VGVAVLNDLL YAVGGHDGQS YLNSIERYDP
QTNQWSCDVA PTTSCRTSVG VAVLDGFLYA VGGQDGVQCL NHVERYDPKE NKWSKVAPMT
TRRLGVAVAV LGGYLYAIGG SDGQCPLNTV ERYDPRQNKW CAVSPMSTRR KHLGCAVFNN
FIYAVGGRDD CMELSSAERY NPHTNSWSPI VAMTSRRSGV GLAVVNGQLY AVGGFDGTAY
LKTIEVYDPE TNQWRLCGCM NYRRLGGGVG VMRAPQTENY MW
