ID   KLHDB_CULQU             Reviewed;         582 AA.
AC   B0WWP2;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 2.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Kelch-like protein diablo {ECO:0000250|UniProtKB:Q9VUU5};
GN   Name=dbo {ECO:0000250|UniProtKB:Q9VUU5}; ORFNames=CPIJ011612;
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1] {ECO:0000312|EMBL:EDS36134.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB {ECO:0000312|EMBL:EDS36134.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA   Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable substrate-specific adapter of an E3 ubiquitin-
CC       protein ligase complex which mediates the ubiquitination and subsequent
CC       proteasomal degradation of target proteins. May have a role in synapse
CC       differentiation and growth (By similarity).
CC       {ECO:0000250|UniProtKB:Q9VUU5, ECO:0000250|UniProtKB:Q9Y2M5}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000250|UniProtKB:Q9Y2M5}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDS36134.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; DS232150; EDS36134.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001861814.1; XM_001861779.1.
DR   AlphaFoldDB; B0WWP2; -.
DR   SMR; B0WWP2; -.
DR   STRING; 7176.CPIJ011612-PA; -.
DR   EnsemblMetazoa; XM_038253265.1; XP_038109193.1; LOC6044283.
DR   GeneID; 6044283; -.
DR   KEGG; cqu:CpipJ_CPIJ011612; -.
DR   VEuPathDB; VectorBase:CPIJ011612; -.
DR   VEuPathDB; VectorBase:CPIJ011613; -.
DR   VEuPathDB; VectorBase:CQUJHB003481; -.
DR   eggNOG; KOG4441; Eukaryota.
DR   HOGENOM; CLU_004253_14_2_1; -.
DR   InParanoid; B0WWP2; -.
DR   OrthoDB; 1596048at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000002320; Partially assembled WGS sequence.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0045886; P:negative regulation of synaptic assembly at neuromuscular junction; ISS:UniProtKB.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR017096; BTB-kelch_protein.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 6.
DR   PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 6.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF50965; SSF50965; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   3: Inferred from homology;
KW   Actin-binding; Kelch repeat; Reference proteome; Repeat;
KW   Ubl conjugation pathway.
FT   CHAIN           1..582
FT                   /note="Kelch-like protein diablo"
FT                   /id="PRO_0000379944"
FT   DOMAIN          41..108
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          143..245
FT                   /note="BACK"
FT                   /evidence="ECO:0000255"
FT   REPEAT          292..338
FT                   /note="Kelch 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          340..386
FT                   /note="Kelch 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          387..433
FT                   /note="Kelch 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          435..480
FT                   /note="Kelch 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          482..527
FT                   /note="Kelch 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          528..574
FT                   /note="Kelch 6"
FT                   /evidence="ECO:0000255"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   582 AA;  65228 MW;  F154775E0C2C86D9 CRC64;
     MGDVLISDRP PSPARLSHTS EKHPRVTLTE LNVLRRHREL CDVVINVSGR KIFAHRVILS
     ACSPYFRAMF TGELEESRQT EVTIRDIDEN AMELLIDFCY TSHIVVEESN VQTLLPAACL
     LQLAEIQDIC CEFLKRQLDP TNCLGIRAFA DTHSCRELLR IADKFTQHNF QEVMESEEFL
     LLPVGQLVDI ICSDELNVRS EEQVFNAVMA WLKYNVAERR QHLAQVLQHV RMPLLSPKFL
     VGTVGSDLLV RSDEACRDLV DEAKNYLLLP QERPLMQGPR TRPRKPTRRG EVLFAVGGWC
     SGDAIASVER FDPETADWKM VAPMSKRRCG VGVAVLNDLL YAVGGHDGQS YLNSIERYDP
     QTNQWSCDVA PTTSCRTSVG VAVLDGFLYA VGGQDGVQCL NHVERYDPKE NKWSKVAPMT
     TRRLGVAVAV LGGYLYAIGG SDGQCPLNTV ERYDPRQNKW CAVSPMSTRR KHLGCAVFNN
     FIYAVGGRDD CMELSSAERY NPHTNSWSPI VAMTSRRSGV GLAVVNGQLY AVGGFDGTAY
     LKTIEVYDPE TNQWRLCGCM NYRRLGGGVG VMRAPQTENY MW