ID   KLHDB_DROAN             Reviewed;         633 AA.
AC   B3M9V8;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 2.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Kelch-like protein diablo {ECO:0000250|UniProtKB:Q9VUU5};
GN   Name=dbo {ECO:0000250|UniProtKB:Q9VUU5}; ORFNames=GF24095;
OS   Drosophila ananassae (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7217;
RN   [1] {ECO:0000312|EMBL:EDV40149.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14024-0371.13 {ECO:0000312|EMBL:EDV40149.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Probable substrate-specific adapter of an E3 ubiquitin-
CC       protein ligase complex which mediates the ubiquitination and subsequent
CC       proteasomal degradation of target proteins. May have a role in synapse
CC       differentiation and growth (By similarity).
CC       {ECO:0000250|UniProtKB:Q9VUU5, ECO:0000250|UniProtKB:Q9Y2M5}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000250|UniProtKB:Q9Y2M5}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDV40149.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CH902618; EDV40149.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001957343.2; XM_001957307.2.
DR   AlphaFoldDB; B3M9V8; -.
DR   SMR; B3M9V8; -.
DR   STRING; 7217.FBpp0127287; -.
DR   EnsemblMetazoa; FBtr0391646; FBpp0351081; FBgn0101089.
DR   GeneID; 6506729; -.
DR   KEGG; dan:6506729; -.
DR   eggNOG; KOG4441; Eukaryota.
DR   InParanoid; B3M9V8; -.
DR   OrthoDB; 731760at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000007801; Unassembled WGS sequence.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:EnsemblMetazoa.
DR   GO; GO:0045886; P:negative regulation of synaptic assembly at neuromuscular junction; ISS:UniProtKB.
DR   GO; GO:0051865; P:protein autoubiquitination; IEA:EnsemblMetazoa.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR017096; BTB-kelch_protein.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 6.
DR   PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 6.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF50965; SSF50965; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   3: Inferred from homology;
KW   Actin-binding; Kelch repeat; Reference proteome; Repeat;
KW   Ubl conjugation pathway.
FT   CHAIN           1..633
FT                   /note="Kelch-like protein diablo"
FT                   /id="PRO_0000379945"
FT   DOMAIN          80..147
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          182..284
FT                   /note="BACK"
FT                   /evidence="ECO:0000255"
FT   REPEAT          331..377
FT                   /note="Kelch 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          379..425
FT                   /note="Kelch 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          426..472
FT                   /note="Kelch 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          474..519
FT                   /note="Kelch 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          521..566
FT                   /note="Kelch 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          567..613
FT                   /note="Kelch 6"
FT                   /evidence="ECO:0000255"
FT   REGION          1..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..47
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   633 AA;  69565 MW;  E8AC5423C0213612 CRC64;
     MGDLPGSTGG GGGVGGGGNG GGGPTIAGTN GNSTTGPGSS TGSTGLERPP SPARLSHTSE
     KHPKVTLSEL NMLRRHRELC DVVLNVGGRK IFAHRVILSA CSSYFCAMFT GELEESRQTE
     VTIRDIDENA MELLIDFCYT AHIIVEESNV QTLLPAACLL QLVEIQDICC EFLKRQLDPT
     NCLGIRAFAD THSCRELLRI ADKFTQHNFQ EVMESEEFLL LPVGQLVDII CSDELNVRSE
     EQVFNAVMSW LKYNVAERRQ HLPQVLQHVR LPLLSPKFLV GTVGSDLLVR SDEACRDLVD
     EAKNYLLLPQ ERPLMQGPRT RPRKPTRRGE VLFAVGGWCS GDAIASVERF DPQTNDWKMV
     APMSKRRCGV GVAVLNDLLY AVGGHDGQSY LNSIERYDPQ TNQWSCDVAP TTSCRTSVGV
     AVLDGFLYAV GGQDGVQCLN HVERYDPKEN KWSKVAPMTT RRLGVAVAVL GGFLYAIGGS
     DGQCPLNTVE RYDPRHNKWV AVSPMSTRRK HLGCAVFNNY IYAVGGRDDC MELSSAERYN
     PLTNTWSPIV AMTSRRSGVG LAVVNGQLYA VGGFDGSAYL KTIEVYDPET NQWRLCGCMN
     YRRLGGGVGV MRAPQTENYM WCENSFKQQA TSN