KLHDB_DROPS
ID KLHDB_DROPS Reviewed; 628 AA.
AC Q2M0J9;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 2.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Kelch-like protein diablo {ECO:0000250|UniProtKB:Q9VUU5};
GN Name=dbo {ECO:0000250|UniProtKB:Q9VUU5}; ORFNames=GA19454;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1] {ECO:0000312|EMBL:EAL30933.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Probable substrate-specific adapter of an E3 ubiquitin-
CC protein ligase complex which mediates the ubiquitination and subsequent
CC proteasomal degradation of target proteins. May have a role in synapse
CC differentiation and growth (By similarity).
CC {ECO:0000250|UniProtKB:Q9VUU5, ECO:0000250|UniProtKB:Q9Y2M5}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000250|UniProtKB:Q9Y2M5}.
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DR EMBL; CH379069; EAL30933.2; -; Genomic_DNA.
DR RefSeq; XP_015042832.1; XM_015187346.1.
DR RefSeq; XP_015042833.1; XM_015187347.1.
DR AlphaFoldDB; Q2M0J9; -.
DR SMR; Q2M0J9; -.
DR STRING; 7237.FBpp0275031; -.
DR EnsemblMetazoa; FBtr0366069; FBpp0329308; FBgn0079450.
DR EnsemblMetazoa; FBtr0378882; FBpp0339605; FBgn0079450.
DR GeneID; 4813272; -.
DR KEGG; dpo:Dpse_GA19454; -.
DR eggNOG; KOG4441; Eukaryota.
DR HOGENOM; CLU_004253_14_2_1; -.
DR InParanoid; Q2M0J9; -.
DR OMA; NSWSPIV; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000001819; Chromosome X.
DR Bgee; FBgn0079450; Expressed in female reproductive system and 2 other tissues.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:EnsemblMetazoa.
DR GO; GO:0045886; P:negative regulation of synaptic assembly at neuromuscular junction; ISS:UniProtKB.
DR GO; GO:0051865; P:protein autoubiquitination; IEA:EnsemblMetazoa.
DR Gene3D; 2.120.10.80; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 6.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF117281; SSF117281; 1.
DR SUPFAM; SSF50965; SSF50965; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 3: Inferred from homology;
KW Actin-binding; Kelch repeat; Reference proteome; Repeat;
KW Ubl conjugation pathway.
FT CHAIN 1..628
FT /note="Kelch-like protein diablo"
FT /id="PRO_0000379951"
FT DOMAIN 74..141
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 176..278
FT /note="BACK"
FT /evidence="ECO:0000255"
FT REPEAT 325..371
FT /note="Kelch 1"
FT /evidence="ECO:0000255"
FT REPEAT 373..419
FT /note="Kelch 2"
FT /evidence="ECO:0000255"
FT REPEAT 420..466
FT /note="Kelch 3"
FT /evidence="ECO:0000255"
FT REPEAT 468..513
FT /note="Kelch 4"
FT /evidence="ECO:0000255"
FT REPEAT 515..560
FT /note="Kelch 5"
FT /evidence="ECO:0000255"
FT REPEAT 561..607
FT /note="Kelch 6"
FT /evidence="ECO:0000255"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 628 AA; 69197 MW; C4CE0AF05E471E23 CRC64;
MGDLPGSTGG GSGPAAAGNA SGNASSAGNT GLGVAGTTGV DRPPSPARLS HTSEKHPKVT
LTELNMLRRH RELCDVVLNV GGRKIFAHRV ILSACSSYFC AMFTGELEES RQTEVTIRDI
DENAMELLID FCYTAHIIVE ESNVQTLLPA ACLLQLVEIQ DICCEFLKRQ LDPTNCLGIR
AFADTHSCRE LLRIADKFTQ HNFQEVMESE EFLLLPVGQL VDIICSDELN VRSEEQVFNA
VMSWLKYNVA ERRQHLAQVL QHVRLPLLSP KFLVGTVGSD LLVRSDEACR DLVDEAKNYL
LLPQERPLMQ GPRTRPRKPT RRGEVLFAVG GWCSGDAIAS VERFDPQTND WKMVAPMSKR
RCGVGVAVLN DLLYAVGGHD GQSYLNSIER YDPQTNQWSC DVAPTTSCRT SVGVAVLDGF
LYAVGGQDGV QCLNHVERYD PKENKWSKVA PMTTRRLGVA VAVLGGFLYA IGGSDGQCPL
NTVERYDPRQ NKWVAVSPMS TRRKHLGCAV FNNYIYAVGG RDDCMELSSA ERYNPLTNTW
SPIVAMTSRR SGVGLAVVNG QLYAVGGFDG SAYLKTIEVY DPETNQWRLC GCMNYRRLGG
GVGVMRAPQT ENYMWCENSL KQHNNPPS
