KLHL1_MOUSE
ID KLHL1_MOUSE Reviewed; 751 AA.
AC Q9JI74; Q505E9;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Kelch-like protein 1;
GN Name=Klhl1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10888605; DOI=10.1093/hmg/9.10.1543;
RA Koob M.D., Nemes J.P., Benzow K.A.;
RT "The SCA8 transcript is an antisense RNA to a brain-specific transcript
RT encoding a novel actin-binding protein (KLHL1).";
RL Hum. Mol. Genet. 9:1543-1551(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in organizing the actin cytoskeleton of the
CC brain cells.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC -!- TISSUE SPECIFICITY: Highly expressed in brain.
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DR EMBL; AF252281; AAF81717.1; -; mRNA.
DR EMBL; AC131920; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC131989; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC154580; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CT025590; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC094584; AAH94584.1; -; mRNA.
DR CCDS; CCDS27308.1; -.
DR RefSeq; NP_444335.2; NM_053105.2.
DR AlphaFoldDB; Q9JI74; -.
DR SMR; Q9JI74; -.
DR BioGRID; 220238; 12.
DR STRING; 10090.ENSMUSP00000022666; -.
DR iPTMnet; Q9JI74; -.
DR PhosphoSitePlus; Q9JI74; -.
DR UCD-2DPAGE; Q9JI74; -.
DR MaxQB; Q9JI74; -.
DR PaxDb; Q9JI74; -.
DR PRIDE; Q9JI74; -.
DR ProteomicsDB; 263657; -.
DR Antibodypedia; 9985; 273 antibodies from 30 providers.
DR DNASU; 93688; -.
DR Ensembl; ENSMUST00000022666; ENSMUSP00000022666; ENSMUSG00000022076.
DR GeneID; 93688; -.
DR KEGG; mmu:93688; -.
DR UCSC; uc007uuq.1; mouse.
DR CTD; 57626; -.
DR MGI; MGI:2136335; Klhl1.
DR VEuPathDB; HostDB:ENSMUSG00000022076; -.
DR eggNOG; KOG4441; Eukaryota.
DR GeneTree; ENSGT00940000160425; -.
DR HOGENOM; CLU_004253_12_0_1; -.
DR InParanoid; Q9JI74; -.
DR OMA; CGHRLTA; -.
DR OrthoDB; 709680at2759; -.
DR PhylomeDB; Q9JI74; -.
DR TreeFam; TF329218; -.
DR BioGRID-ORCS; 93688; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Klhl1; mouse.
DR PRO; PR:Q9JI74; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q9JI74; protein.
DR Bgee; ENSMUSG00000022076; Expressed in ventral tegmental area and 65 other tissues.
DR Genevisible; Q9JI74; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0030425; C:dendrite; IDA:MGI.
DR GO; GO:0043025; C:neuronal cell body; IDA:MGI.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0007628; P:adult walking behavior; IMP:MGI.
DR GO; GO:0021680; P:cerebellar Purkinje cell layer development; IMP:MGI.
DR GO; GO:0016358; P:dendrite development; IMP:MGI.
DR GO; GO:0007626; P:locomotory behavior; IMP:MGI.
DR Gene3D; 2.120.10.80; -; 2.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 6.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF117281; SSF117281; 2.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 2: Evidence at transcript level;
KW Actin-binding; Cytoplasm; Cytoskeleton; Kelch repeat; Reference proteome;
KW Repeat.
FT CHAIN 1..751
FT /note="Kelch-like protein 1"
FT /id="PRO_0000119100"
FT DOMAIN 215..282
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT REPEAT 463..509
FT /note="Kelch 1"
FT REPEAT 510..556
FT /note="Kelch 2"
FT REPEAT 558..603
FT /note="Kelch 3"
FT REPEAT 604..650
FT /note="Kelch 4"
FT REPEAT 652..703
FT /note="Kelch 5"
FT REPEAT 704..750
FT /note="Kelch 6"
FT REGION 25..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 69..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 139
FT /note="S -> P (in Ref. 1; AAF81717)"
FT /evidence="ECO:0000305"
FT CONFLICT 142
FT /note="E -> Q (in Ref. 1; AAF81717)"
FT /evidence="ECO:0000305"
FT CONFLICT 196
FT /note="H -> R (in Ref. 1; AAF81717)"
FT /evidence="ECO:0000305"
FT CONFLICT 634
FT /note="A -> P (in Ref. 1; AAF81717)"
FT /evidence="ECO:0000305"
FT CONFLICT 639
FT /note="R -> K (in Ref. 1; AAF81717)"
FT /evidence="ECO:0000305"
FT CONFLICT 677
FT /note="D -> E (in Ref. 1; AAF81717)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 751 AA; 82892 MW; D8296768D56EB894 CRC64;
MSGSGRKDFD VKHILRLRWK LFSHPSPASS SPAGGSCLQQ DSGGGSFEHW GPSQSRLLKN
QEKGSVSAFW KKPSSSSSSS SSSSSSASSS PFNPLNGTLL PVATRLQQGA PGQGTQQPAR
TLFYVESLEE EVVTGMDFSG PEDKGLALKE LQAEPASSIQ ATGEGCGHRL TSTNHSLTPQ
SDLDSSSSEE FYQAVHHAEQ SFRKMENYLK QQQLCDVILI VGNRKIPAHR LVLSSVSDYF
AAMFTSDVCE AKQEEIKMEG IDPNALWDLV QFAYTGCLEL KEDTIENLLA AACLLQLPQV
VEVCCHFLMK LLHPSNCLGI RAFADAQGCI ELMKVAHSYT MENIMEVIRN QEFLLLPAEE
LHKLLASDDV NVPDEETIFH ALMMWVKYDM QRRCSDLSML LAFIRLPLLP PQILADLENH
ALFKNDLECQ KLILEAMKYH LLPERRTLMQ SPRTKPRKST VGTLYAVGGM DNNKGATTIE
KYDLRTNLWI QAGMMNGRRL QFGVAVIDDK LFVIGGRDGL KTLNTVECYN PKTKTWTVLP
PMSTHRHGLG VTVLEGPIYA VGGHDGWSYL NTVERWDPQS QQWTYVASMS IARSTVGVAA
LNGKLYSVGG RDGSSCLSSM EYYDPHTNKW SMCAPMCKRR GGVGVATCDG FLYAVGGHDA
PASNHCSRLL DYVERYDPKT DTWTMVAPLS MPRDAVGVCL LGDRLYAVGG YDGQTYLNTM
ESYDPQTNEW TQMASLNIGR AGACVVVIKQ P
