KLHL6_HUMAN
ID KLHL6_HUMAN Reviewed; 621 AA.
AC Q8WZ60; B2RB31; D3DNS8; Q8N5I1; Q8N892;
DT 12-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 3.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=Kelch-like protein 6;
GN Name=KLHL6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen, and Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Blood;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 11-621, AND TISSUE SPECIFICITY.
RX PubMed=12617994; DOI=10.1016/s0161-5890(03)00002-6;
RA Gupta-Rossi N., Storck S., Griebel P.J., Reynaud C.-A., Weill J.-C.,
RA Dahan A.;
RT "Specific over-expression of deltex and a new Kelch-like protein in human
RT germinal center B cells.";
RL Mol. Immunol. 39:791-799(2003).
CC -!- FUNCTION: Involved in B-lymphocyte antigen receptor signaling and
CC germinal center formation. {ECO:0000250}.
CC -!- INTERACTION:
CC Q8WZ60; Q13895: BYSL; NbExp=3; IntAct=EBI-6426464, EBI-358049;
CC Q8WZ60; Q49AN0: CRY2; NbExp=5; IntAct=EBI-6426464, EBI-2212355;
CC Q8WZ60; P07954: FH; NbExp=3; IntAct=EBI-6426464, EBI-1050358;
CC Q8WZ60; Q8IVD9: NUDCD3; NbExp=2; IntAct=EBI-6426464, EBI-744342;
CC Q8WZ60; Q9UD71: PPP1R1B; NbExp=3; IntAct=EBI-6426464, EBI-722119;
CC Q8WZ60; O60260-5: PRKN; NbExp=3; IntAct=EBI-6426464, EBI-21251460;
CC Q8WZ60; Q9Y3A5: SBDS; NbExp=3; IntAct=EBI-6426464, EBI-1046471;
CC Q8WZ60; P42167: TMPO; NbExp=3; IntAct=EBI-6426464, EBI-455283;
CC -!- TISSUE SPECIFICITY: Found in germinal center B-cells.
CC {ECO:0000269|PubMed:12617994}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH32348.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAL35594.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAG37078.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK097125; BAC04957.1; -; mRNA.
DR EMBL; AK314473; BAG37078.1; ALT_INIT; mRNA.
DR EMBL; AC092960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC069211; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471052; EAW78324.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW78325.1; -; Genomic_DNA.
DR EMBL; BC032348; AAH32348.1; ALT_INIT; mRNA.
DR EMBL; AF441792; AAL35594.1; ALT_INIT; mRNA.
DR CCDS; CCDS3245.2; -.
DR RefSeq; NP_569713.2; NM_130446.2.
DR AlphaFoldDB; Q8WZ60; -.
DR SMR; Q8WZ60; -.
DR BioGRID; 124622; 26.
DR IntAct; Q8WZ60; 13.
DR STRING; 9606.ENSP00000341342; -.
DR iPTMnet; Q8WZ60; -.
DR PhosphoSitePlus; Q8WZ60; -.
DR BioMuta; KLHL6; -.
DR DMDM; 229462964; -.
DR EPD; Q8WZ60; -.
DR MassIVE; Q8WZ60; -.
DR MaxQB; Q8WZ60; -.
DR PaxDb; Q8WZ60; -.
DR PeptideAtlas; Q8WZ60; -.
DR PRIDE; Q8WZ60; -.
DR ProteomicsDB; 75222; -.
DR TopDownProteomics; Q8WZ60; -.
DR Antibodypedia; 18928; 107 antibodies from 25 providers.
DR DNASU; 89857; -.
DR Ensembl; ENST00000341319.8; ENSP00000341342.3; ENSG00000172578.12.
DR GeneID; 89857; -.
DR KEGG; hsa:89857; -.
DR MANE-Select; ENST00000341319.8; ENSP00000341342.3; NM_130446.4; NP_569713.2.
DR UCSC; uc003flr.4; human.
DR CTD; 89857; -.
DR DisGeNET; 89857; -.
DR GeneCards; KLHL6; -.
DR HGNC; HGNC:18653; KLHL6.
DR HPA; ENSG00000172578; Tissue enriched (lymphoid).
DR MIM; 614214; gene.
DR neXtProt; NX_Q8WZ60; -.
DR OpenTargets; ENSG00000172578; -.
DR PharmGKB; PA38621; -.
DR VEuPathDB; HostDB:ENSG00000172578; -.
DR eggNOG; KOG4441; Eukaryota.
DR GeneTree; ENSGT00940000154345; -.
DR HOGENOM; CLU_004253_14_2_1; -.
DR InParanoid; Q8WZ60; -.
DR OMA; PSTNKWN; -.
DR OrthoDB; 279729at2759; -.
DR PhylomeDB; Q8WZ60; -.
DR TreeFam; TF351654; -.
DR PathwayCommons; Q8WZ60; -.
DR SignaLink; Q8WZ60; -.
DR BioGRID-ORCS; 89857; 12 hits in 1110 CRISPR screens.
DR ChiTaRS; KLHL6; human.
DR GenomeRNAi; 89857; -.
DR Pharos; Q8WZ60; Tbio.
DR PRO; PR:Q8WZ60; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q8WZ60; protein.
DR Bgee; ENSG00000172578; Expressed in epithelium of nasopharynx and 141 other tissues.
DR ExpressionAtlas; Q8WZ60; baseline and differential.
DR Genevisible; Q8WZ60; HS.
DR GO; GO:0050853; P:B cell receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0002467; P:germinal center formation; IEA:Ensembl.
DR GO; GO:0009617; P:response to bacterium; IEA:Ensembl.
DR Gene3D; 2.120.10.80; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR029851; KLHL6.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR24412:SF428; PTHR24412:SF428; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 3.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 5.
DR SUPFAM; SSF117281; SSF117281; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 1: Evidence at protein level;
KW Kelch repeat; Reference proteome; Repeat.
FT CHAIN 1..621
FT /note="Kelch-like protein 6"
FT /id="PRO_0000119106"
FT DOMAIN 72..139
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 174..276
FT /note="BACK"
FT REPEAT 320..367
FT /note="Kelch 1"
FT REPEAT 378..421
FT /note="Kelch 2"
FT REPEAT 422..468
FT /note="Kelch 3"
FT REPEAT 470..516
FT /note="Kelch 4"
FT REPEAT 517..558
FT /note="Kelch 5"
FT REPEAT 560..606
FT /note="Kelch 6"
FT VARIANT 518
FT /note="I -> V (in dbSNP:rs35354575)"
FT /id="VAR_056125"
FT CONFLICT 11
FT /note="T -> R (in Ref. 5; AAL35594)"
FT /evidence="ECO:0000305"
FT CONFLICT 94
FT /note="S -> G (in Ref. 1; BAG37078)"
FT /evidence="ECO:0000305"
FT CONFLICT 112
FT /note="R -> G (in Ref. 1; BAG37078)"
FT /evidence="ECO:0000305"
FT CONFLICT 363
FT /note="E -> G (in Ref. 5; AAL35594)"
FT /evidence="ECO:0000305"
FT CONFLICT 495
FT /note="K -> R (in Ref. 1; BAG37078)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 621 AA; 70359 MW; 267FD90AEC6629E4 CRC64;
MLMAGQRGAW TMGDVVEKSL EGPLAPSTDE PSQKTGDLVE ILNGEKVKFD DAGLSLILQN
GLETLRMENA LTDVILCVDI QEFSCHRVVL AAASNYFRAM FCNDLKEKYE KRIIIKGVDA
ETMHTLLDYT YTSKALITKQ NVQRVLEAAN LFQFLRMVDA CASFLTEALN PENCVGILRL
ADTHSLDSLK KQVQSYIIQN FVQILNSEEF LDLPVDTLHH ILKSDDLYVT EEAQVFETVM
SWVRHKPSER LCLLPYVLEN VRLPLLDPWY FVETVEADPL IRQCPEVFPL LQEARMYHLS
GNEIISERTK PRMHEFQSEV FMIIGGCTKD ERFVAEVTCL DPLRRSRLEV AKLPLTEHEL
ESENKKWVEF ACVTLKNEVY ISGGKETQHD VWKYNSSINK WIQIEYLNIG RWRHKMVVLG
GKVYVIGGFD GLQRINNVET YDPFHNCWSE AAPLLVHVSS FAATSHKKKL YVIGGGPNGK
LATDKTQCYD PSTNKWSLKA AMPVEAKCIN AVSFRDRIYV VGGAMRALYA YSPLEDSWCL
VTQLSHERAS CGIAPCNNRL YITGGRDEKN EVIATVLCWD PEAQKLTEEC VLPRGVSHHG
SVTIRKSYTH IRRIVPGAVS V
