KLHL6_MOUSE
ID KLHL6_MOUSE Reviewed; 619 AA.
AC Q6V595; Q497G3;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-SEP-2009, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Kelch-like protein 6;
GN Name=Klhl6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6NCr; TISSUE=Hematopoietic stem cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 10-619.
RC STRAIN=BALB/cJ;
RX PubMed=12617994; DOI=10.1016/s0161-5890(03)00002-6;
RA Gupta-Rossi N., Storck S., Griebel P.J., Reynaud C.-A., Weill J.-C.,
RA Dahan A.;
RT "Specific over-expression of deltex and a new Kelch-like protein in human
RT germinal center B cells.";
RL Mol. Immunol. 39:791-799(2003).
RN [4]
RP FUNCTION, DISRUPTION PHENOTYPE, INDUCTION, AND TISSUE SPECIFICITY.
RX PubMed=16166635; DOI=10.1128/mcb.25.19.8531-8540.2005;
RA Kroll J., Shi X., Caprioli A., Liu H.-H., Waskow C., Lin K.-M.,
RA Miyazaki T., Rodewald H.-R., Sato T.N.;
RT "The BTB-kelch protein KLHL6 is involved in B-lymphocyte antigen receptor
RT signaling and germinal center formation.";
RL Mol. Cell. Biol. 25:8531-8540(2005).
CC -!- FUNCTION: Involved in B-lymphocyte antigen receptor signaling and
CC germinal center formation. {ECO:0000269|PubMed:16166635}.
CC -!- TISSUE SPECIFICITY: Expressed in embryonic blood vessel endothelial
CC cells but not in the vasculature of adult organs. In adults, detected
CC at high levels in hematopoietic and lymphoid organs.
CC {ECO:0000269|PubMed:16166635}.
CC -!- INDUCTION: Up-regulated during germinal center formation.
CC {ECO:0000269|PubMed:16166635}.
CC -!- DISRUPTION PHENOTYPE: Mice show impaired antigen-dependent germinal
CC center formation and B-cell antigen receptor (BCR) signaling. The
CC number of mature B-cells is reduced. {ECO:0000269|PubMed:16166635}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI00569.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AC164558; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC100568; AAI00569.1; ALT_INIT; mRNA.
DR EMBL; AY350736; AAQ56719.1; -; mRNA.
DR CCDS; CCDS28041.2; -.
DR RefSeq; NP_899246.2; NM_183390.3.
DR AlphaFoldDB; Q6V595; -.
DR SMR; Q6V595; -.
DR BioGRID; 232123; 1.
DR STRING; 10090.ENSMUSP00000053023; -.
DR PhosphoSitePlus; Q6V595; -.
DR EPD; Q6V595; -.
DR PaxDb; Q6V595; -.
DR PeptideAtlas; Q6V595; -.
DR PRIDE; Q6V595; -.
DR ProteomicsDB; 264776; -.
DR Antibodypedia; 18928; 107 antibodies from 25 providers.
DR Ensembl; ENSMUST00000058839; ENSMUSP00000053023; ENSMUSG00000043008.
DR GeneID; 239743; -.
DR KEGG; mmu:239743; -.
DR UCSC; uc007ypg.2; mouse.
DR CTD; 89857; -.
DR MGI; MGI:2686922; Klhl6.
DR VEuPathDB; HostDB:ENSMUSG00000043008; -.
DR eggNOG; KOG4441; Eukaryota.
DR GeneTree; ENSGT00940000154345; -.
DR HOGENOM; CLU_004253_14_2_1; -.
DR InParanoid; Q6V595; -.
DR OMA; PSTNKWN; -.
DR OrthoDB; 279729at2759; -.
DR PhylomeDB; Q6V595; -.
DR TreeFam; TF351654; -.
DR BioGRID-ORCS; 239743; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q6V595; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q6V595; protein.
DR Bgee; ENSMUSG00000043008; Expressed in mesenteric lymph node and 175 other tissues.
DR Genevisible; Q6V595; MM.
DR GO; GO:0050853; P:B cell receptor signaling pathway; IMP:UniProtKB.
DR GO; GO:0002467; P:germinal center formation; IMP:UniProtKB.
DR GO; GO:0009617; P:response to bacterium; IEP:MGI.
DR Gene3D; 2.120.10.80; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR029851; KLHL6.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR24412:SF428; PTHR24412:SF428; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 3.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 5.
DR SUPFAM; SSF117281; SSF117281; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 2: Evidence at transcript level;
KW Kelch repeat; Reference proteome; Repeat.
FT CHAIN 1..619
FT /note="Kelch-like protein 6"
FT /id="PRO_0000119107"
FT DOMAIN 70..137
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 172..274
FT /note="BACK"
FT REPEAT 318..365
FT /note="Kelch 1"
FT REPEAT 376..419
FT /note="Kelch 2"
FT REPEAT 420..466
FT /note="Kelch 3"
FT REPEAT 468..514
FT /note="Kelch 4"
FT REPEAT 515..556
FT /note="Kelch 5"
FT REPEAT 558..604
FT /note="Kelch 6"
FT CONFLICT 139
FT /note="N -> K (in Ref. 3; AAQ56719)"
FT /evidence="ECO:0000305"
FT CONFLICT 161
FT /note="S -> N (in Ref. 2; AAI00569)"
FT /evidence="ECO:0000305"
FT CONFLICT 194
FT /note="Y -> C (in Ref. 3; AAQ56719)"
FT /evidence="ECO:0000305"
FT CONFLICT 335
FT /note="V -> A (in Ref. 2; AAI00569)"
FT /evidence="ECO:0000305"
FT CONFLICT 428
FT /note="D -> G (in Ref. 2; AAI00569)"
FT /evidence="ECO:0000305"
FT CONFLICT 448
FT /note="E -> G (in Ref. 2; AAI00569)"
FT /evidence="ECO:0000305"
FT CONFLICT 486
FT /note="C -> W (in Ref. 3; AAQ56719)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 619 AA; 70191 MW; 18A89D05C6378666 CRC64;
MAGQRGACTM SDVVERSLEG PLALTTDKSS QKRGDLVEIL TGEKVKFDDT RLSLILQNGL
ETLREENALT DVILCVDVQE FSCHRVVLAA ASNYFRAMFC NDLKEKYEKR IIIKGVDAET
MHTLLVYTYT SKALITKQNV QRVLEAANLF QFLQLVDACA SFLTEALNPE NCIGILRLAD
THSLDSLKMQ VQSYIIQNFV QILNSEEFLE LPVDTLYHIL RSDDLCVTEE AQVFETVMSW
VRHKQSERLC LLPCVLENVR LPLLDPWYFV EMVEADPLIR QCPEVFPLLQ EARMYHLSGN
EIISERTKPR MHEFQSEVFM IIGGCTKDER FVAEVTCLDP LRRSRLEVAK LPLTEHELES
ENKKWVEFAC VTLKNEVYIS GGKETQHDVW KYNSSINKWI QIEYLNIGRW RHKMVVLGGK
VYVLGGFDGL QRINNVETYD PFHNCWSEAA PLHVHVSSFA ATSHKKKLYV IGGGPNGKLA
TDKTQCYDPS TNKWVLKSAM PVEAKCINAV SFQDHIYVVG GAMRALYAYS PLEDSWCLVT
QLSHERASCG IAPCNNKLYI TGGRDEKNEV IATVLCWDPE AQKLTEECVL PRGVSHHGSV
TIRKSYTHIR RVVPGAVSV
